MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 884 products of "MAPK"

Purity (%)

100

products per page.

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Rac1-IN-3
CAS:
- 380470-06-4
Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].
Formula:C₂₁H₂₃N₇O₂
Purity:98%
Color and Shape:Solid
Molecular weight:405.45
Ref: TM-T79869
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BI-0474
CAS:
- 2750570-55-7
BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.
Formula:C₃₀H₃₇N₉O₂S
Purity:99.61%
Color and Shape:Solid
Molecular weight:587.74
Ref: TM-T69529
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FGTI-2734 mesylate (1247018-19-4 free base)
CAS:
- 2702297-24-1
FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.
Formula:C₂₇H₃₅FN₆O₅S₂
Purity:98%
Color and Shape:Solid
Molecular weight:606.73
Ref: TM-T11282L
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(R)-VX-11e
CAS:
- 1680187-43-2
(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.
Formula:C₂₄H₂₀Cl₂FN₅O₂
Purity:98.73%
Color and Shape:Solid
Molecular weight:500.35
Ref: TM-T78143
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ERK-IN-2 free base
CAS:
- 2743576-55-6
ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.
Formula:C₁₆H₁₇N₅O₂
Color and Shape:Solid
Molecular weight:311.34
Ref: TM-T72517
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KRAS G12C inhibitor 59
CAS:
- 2914919-88-1
KRAS G12C Inhibitor 59 is a compound with anticancer properties.
Formula:C₃₂H₃₉F₆N₇O₅
Purity:98%
Color and Shape:Solid
Molecular weight:715.69
Ref: TM-T79150
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KRAS inhibitor FB9
CAS:
- 2042365-57-9
KRAS inhibitor FB9 can be used in studies about Ras.
Formula:C₂₃H₂₁ClF₄N₂O₅
Color and Shape:Solid
Molecular weight:516.87
Ref: TM-T77806
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HPK1-IN-11
CAS:
- 2734167-68-9
HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.
Formula:C₂₇H₂₅N₅O₂
Color and Shape:Solid
Molecular weight:451.52
Ref: TM-T62742
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DT-061
CAS:
- 1809427-19-7
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
Formula:C₂₅H₂₃F₃N₂O₅S
Purity:98%
Color and Shape:Solid
Molecular weight:520.52
Ref: TM-T10060L
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KRAS G12C inhibitor 16
CAS:
- 2349392-79-4
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
Formula:C₂₄H₂₁ClFN₃O₃
Purity:97.84%
Color and Shape:Solid
Molecular weight:453.89
Ref: TM-T11770
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CXJ-2
CAS:
- 2919976-92-2
CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.
Formula:C₅₅H₈₇N₁₅O₂₂
Purity:98%
Color and Shape:Solid
Molecular weight:1310.37
Ref: TM-T74782
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KRAS G12C inhibitor 58
CAS:
- 2915599-52-7
KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].
Formula:C₅₁H₆₄ClF₄N₉O₈S
Purity:98%
Color and Shape:Solid
Molecular weight:1074.62
Ref: TM-T79057
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XRP44X
CAS:
- 729605-21-4
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Formula:C₂₁H₂₁ClN₄O
Purity:99.67%
Color and Shape:Solid
Molecular weight:380.87
Ref: TM-T20759
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B-Raf IN 15
CAS:
- 832107-31-0
B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.
Formula:C₁₉H₁₅N₃OS
Purity:98%
Color and Shape:Solid
Molecular weight:333.41
Ref: TM-T78183
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MNK inhibitor 9
CAS:
- 1889336-59-7
MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.
Formula:C₂₅H₂₉N₉O
Color and Shape:Solid
Molecular weight:471.56
Ref: TM-T72752
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KRAS G12C inhibitor 61
CAS:
- 2300967-40-0
KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.
Formula:C₃₁H₃₃ClFN₇O₂
Purity:98%
Color and Shape:Solid
Molecular weight:590.09
Ref: TM-T79808
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KRAS inhibitor-11
KRAS inhibitor-11 is a KRAS inhibitor .
Formula:C₂₉H₄₇N₉O₆
Color and Shape:Solid
Molecular weight:617.74
Ref: TM-T72599
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DL-threo dihydrosphingosine
CAS:
- 2304-75-8
DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.
Formula:C₁₈H₃₉NO₂
Color and Shape:Solid
Molecular weight:301.51
Ref: TM-T27189
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KRAS G12C inhibitor 1R
CAS:
- 2927439-07-2
KRAS G12C inhibitor 1R can be used in studies about Ras.
Formula:C₃₁H₃₆ClFN₆O₂
Color and Shape:Soild
Molecular weight:579.11
Ref: TM-T77802
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KRAS inhibitor-14
CAS:
- 2230873-78-4
KRAS inhibitor-14 targets G12C (IC50: 0.249 μM) and inhibits p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancers.
Formula:C₂₀H₁₅Cl₃FN₃O₂S
Color and Shape:Solid
Molecular weight:486.77
Ref: TM-T63235

MAPK

Found 884 products of "MAPK"

Rac1-IN-3

Ref: TM-T79869

BI-0474

Ref: TM-T69529

FGTI-2734 mesylate (1247018-19-4 free base)

Ref: TM-T11282L

(R)-VX-11e

Ref: TM-T78143

ERK-IN-2 free base

Ref: TM-T72517

KRAS G12C inhibitor 59

Ref: TM-T79150

KRAS inhibitor FB9

Ref: TM-T77806

HPK1-IN-11

Ref: TM-T62742

DT-061

Ref: TM-T10060L

KRAS G12C inhibitor 16

Ref: TM-T11770

CXJ-2

Ref: TM-T74782

KRAS G12C inhibitor 58

Ref: TM-T79057

XRP44X

Ref: TM-T20759

B-Raf IN 15

Ref: TM-T78183

MNK inhibitor 9

Ref: TM-T72752

KRAS G12C inhibitor 61

Ref: TM-T79808

KRAS inhibitor-11

Ref: TM-T72599

DL-threo dihydrosphingosine

Ref: TM-T27189

KRAS G12C inhibitor 1R

Ref: TM-T77802

KRAS inhibitor-14

Ref: TM-T63235