MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 884 products of "MAPK"
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Tinlorafenib
CAS:<p>Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.</p>Formula:C19H19ClF2N4O3SColor and Shape:SolidMolecular weight:456.89PHT-7.3
CAS:<p>PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitor</p>Formula:C24H23N3O3SPurity:98%Color and Shape:SolidMolecular weight:433.52BRAF V600E/CRAF-IN-1
CAS:<p>BRAF V600E/CRAF-IN-1: potent BRAF/CRAF inhibitor, induces cell cycle arrest and apoptosis in HCT-116 cells, promising for cancer research.</p>Formula:C25H17F6N3O2Color and Shape:SolidMolecular weight:505.41KRAS inhibitor-6
CAS:<p>KRAS inhibitor-6 is a potent KRAS G12C inhibitor.</p>Formula:C27H30ClF2N5O3Purity:98%Color and Shape:SolidMolecular weight:546.01(R)-STU104
CAS:<p>(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.</p>Formula:C18H18O4Purity:98.91% - 99.42%Color and Shape:SolidMolecular weight:298.33REDX05358
CAS:<p>REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.</p>Formula:C26H21ClN4O3Color and Shape:SolidMolecular weight:472.92KRAS inhibitor-3
CAS:<p>KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.</p>Formula:C25H27N5OColor and Shape:SolidMolecular weight:413.51Spiclomazine HCl
CAS:<p>Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.</p>Formula:C22H25Cl2N3OS2Color and Shape:SolidMolecular weight:482.49PF-04880594
CAS:<p>PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].</p>Formula:C19H16F2N8Color and Shape:SolidMolecular weight:394.38KRAS G12C inhibitor 48
<p>KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.</p>Formula:C36H39ClN8O2Color and Shape:SolidMolecular weight:651.2KRAS G12C inhibitor 31
CAS:<p>KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.</p>Formula:C25H22ClFN6O3Color and Shape:SolidMolecular weight:508.93Nek2-IN-6
CAS:<p>Nek2-IN-6 inhibitor .</p>Formula:C33H33F3N6O4SColor and Shape:SolidMolecular weight:666.71L-167307
CAS:<p>L-167307 is a p38 kinase inhibitor.</p>Formula:C22H17FN2OSPurity:98%Color and Shape:SolidMolecular weight:376.45KRAS4b-IN-D14
CAS:<p>KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.</p>Formula:C24H24ClN5O4Color and Shape:SolidMolecular weight:481.93HPK1-IN-15
CAS:<p>HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.</p>Formula:C24H21ClF3N5Color and Shape:SolidMolecular weight:471.91KRAS G12D inhibitor 13
CAS:<p>KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).</p>Formula:C31H33F2N7O3Color and Shape:SolidMolecular weight:589.64KRAS G12C inhibitor 42
CAS:<p>KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)</p>Formula:C33H34FN7O2Color and Shape:SolidMolecular weight:579.67p38-α MAPK-IN-4
CAS:<p>p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.</p>Formula:C17H13BrN2OColor and Shape:SolidMolecular weight:341.2LCRF-0004
CAS:<p>LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.</p>Formula:C28H18F4N6O2SColor and Shape:SolidMolecular weight:578.54KRAS G12C inhibitor 39
CAS:<p>KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.</p>Formula:C37H43N9O2Color and Shape:SolidMolecular weight:645.8CBS-3595
CAS:<p>CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.</p>Formula:C18H17FN4O2SPurity:98%Color and Shape:SolidMolecular weight:372.42GP17
CAS:<p>GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.</p>Formula:C26H21F3N4OColor and Shape:SolidMolecular weight:462.47JNK-1-IN-1
CAS:<p>JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.</p>Formula:C24H22N6SColor and Shape:SolidMolecular weight:426.54ADTL-EI1712
CAS:<p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>Formula:C22H18Cl2N4O2S2Color and Shape:SolidMolecular weight:505.44JX 401
CAS:<p>JX 401 is a p38α inhibitor.</p>Formula:C21H25NO2SPurity:98%Color and Shape:SolidMolecular weight:355.49SB 204900
CAS:<p>SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.</p>Formula:C18H17NO2Color and Shape:SolidMolecular weight:279.33HPK1-IN-29
CAS:<p>"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."</p>Formula:C26H18F3N5O2Color and Shape:SolidMolecular weight:489.45DDO3711
CAS:<p>"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."</p>Formula:C42H41N9O6Color and Shape:SolidMolecular weight:767.83KRAS G12C inhibitor 29
CAS:<p>KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.</p>Formula:C23H21ClFN5O2Color and Shape:SolidMolecular weight:453.98-CPT-2Me-cAMP, sodium salt
CAS:<p>8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.</p>Formula:C17H16ClN5NaO6PSColor and Shape:SolidMolecular weight:507.82SCH-53870
CAS:<p>SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.</p>Formula:C18H18N2O4SColor and Shape:SolidMolecular weight:358.41KRAS inhibitor-16
CAS:<p>KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.</p>Formula:C20H16Cl2FN3O2SColor and Shape:SolidMolecular weight:452.33SOS1-IN-12
CAS:<p>SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).</p>Formula:C23H26F3N5Color and Shape:SolidMolecular weight:429.48MTBT
CAS:<p>MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.</p>Formula:C14H11NO2S2Color and Shape:SolidMolecular weight:289.37ARS-2102
CAS:<p>ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .</p>Formula:C28H31ClF2N6O2Color and Shape:SolidMolecular weight:557.03ERK5-IN-4
CAS:<p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>Formula:C16H11Cl2FN4O2Color and Shape:SolidMolecular weight:381.19KRAS inhibitor-15
CAS:<p>KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).</p>Formula:C20H17Cl2FN4OSColor and Shape:SolidMolecular weight:451.34(S)-p38 MAPK Inhibitor III
CAS:<p>(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.</p>Formula:C23H21FN4SColor and Shape:SolidMolecular weight:404.5(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Formula:C16H14ClF2IN2O4Color and Shape:SolidMolecular weight:498.65RAS inhibitor Abd-7
CAS:<p>Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.</p>Formula:C23H25N3O3Color and Shape:SolidMolecular weight:391.46RAF-IN-1
CAS:<p>RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.</p>Formula:C26H22F3N3O4Color and Shape:SolidMolecular weight:497.47KRAS inhibitor-4
CAS:<p>KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.</p>Formula:C30H39ClN8OPurity:98%Color and Shape:SolidMolecular weight:563.14Anti-inflammatory agent 33
CAS:<p>Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.</p>Formula:C22H15N3O5SColor and Shape:SolidMolecular weight:433.44RSK2-IN-3
CAS:<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formula:C24H26N4O5Color and Shape:SolidMolecular weight:450.49MLKL-IN-5
CAS:<p>MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .</p>Formula:C18H20N6O4SColor and Shape:SolidMolecular weight:416.45HPK1-IN-28
CAS:<p>HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.</p>Formula:C25H22F3N5O4Color and Shape:SolidMolecular weight:513.47JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Formula:C24H21BrFN5O5SColor and Shape:SolidMolecular weight:590.42Antifungal agent 46
CAS:<p>Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].</p>Formula:C26H28BrF3N4O2Purity:98%Color and Shape:SolidMolecular weight:565.43p38 MAP Kinase Inhibitor IV
CAS:<p>p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.</p>Formula:C12H4Cl6O4SColor and Shape:SolidMolecular weight:456.94KRAS inhibitor-10
CAS:<p>KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.</p>Formula:C30H37N3O5Color and Shape:SolidMolecular weight:519.63
