MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 892 products of "MAPK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Formula:C32H39F6N7O5Purity:98%Color and Shape:SolidMolecular weight:715.69KRAS G12C inhibitor 13
CAS:KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Formula:C40H46F3N7O4Purity:98%Color and Shape:SolidMolecular weight:745.83KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Formula:C32H37N7O2Purity:98%Color and Shape:SolidMolecular weight:551.68pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formula:C36H34F2N6O3Purity:98%Color and Shape:SolidMolecular weight:636.69TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Formula:C17H16N4O5SPurity:98%Color and Shape:SolidMolecular weight:388.4KRAS G12C inhibitor 51
CAS:KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.Formula:C33H35FN6O3Color and Shape:SolidMolecular weight:582.67KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormula:C30H36FN5O4Purity:98%Color and Shape:SolidMolecular weight:549.64ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Formula:C21H17ClF2N4O2Purity:99.53%Color and Shape:SolidMolecular weight:430.84Ref: TM-T10375
2mg38.00€5mg56.00€10mg94.00€25mg129.00€50mg168.00€100mg235.00€200mg350.00€1mL*10mM (DMSO)63.00€RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Formula:C27H28N4O6SColor and Shape:SolidMolecular weight:536.6GNE 220 hydrochloride
CAS:GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H27ClN8Color and Shape:SolidMolecular weight:474.99B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41KRAS G12C inhibitor 41
CAS:KRAS G12C inhibitor 41 targets a key signaling protein, potentially aiding cancer research.Formula:C36H37ClFN9O2Color and Shape:SolidMolecular weight:682.19SKF-86002 dihydrochloride
CAS:p38 MAP kinase inhibitorFormula:C16H14Cl2FN3SPurity:98%Color and Shape:SolidMolecular weight:370.27B-Raf IN 5
CAS:B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.Formula:C23H18ClF3N6O3S2Color and Shape:SolidMolecular weight:583.01KRAS G12C inhibitor 49
CAS:KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.Formula:C31H31ClN6O3Color and Shape:SolidMolecular weight:571.07SHP2-IN-22
CAS:SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-Formula:C23H22Cl2N8OColor and Shape:SolidMolecular weight:497.38SOS1-IN-5
CAS:SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.
Formula:C26H31F3N4O5Color and Shape:SolidMolecular weight:536.54CHI-000-667
CAS:CHI-000-667 can be used in studies about Ras.Formula:C21H16ClNO4SColor and Shape:SolidMolecular weight:413.87KRAS G12C inhibitor 28
CAS:KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (Formula:C33H36F2N5O4PColor and Shape:SolidMolecular weight:635.64KRAS inhibitor-12
CAS:KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.Formula:C19H16Cl2FN5OSColor and Shape:SolidMolecular weight:452.33Ras inhibitor 134
CAS:Ras inhibitor 134 can be used in studies about Ras.Formula:C23H21ClFN5O3Color and Shape:SoildMolecular weight:469.9ARQ-736
CAS:ARQ 736 effectively targets and inhibits BRAF, crucial in MAPK pathway, beneficial for treating melanomas and certain colon cancers.Formula:C25H25N8Na2O8PSColor and Shape:SolidMolecular weight:674.54DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Formula:C25H23F3N2O5SPurity:98%Color and Shape:SolidMolecular weight:520.52KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Formula:C34H36ClFN10O2Color and Shape:SolidMolecular weight:671.17p38 Kinase inhibitor 4
CAS:Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].Formula:C12H9Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:282.13Kras binder 12
CAS:Kras binder 12 can be used in studies about Ras.Formula:C29H47N9O6Color and Shape:SoildMolecular weight:617.74KRAS degrader-1
CAS:KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].Formula:C55H57Br2ClFIN8O7Color and Shape:SolidMolecular weight:1283.25KRAS inhibitor FB9
CAS:KRAS inhibitor FB9 can be used in studies about Ras.Formula:C23H21ClF4N2O5Color and Shape:SolidMolecular weight:516.87K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Formula:C21H27ClN4O3Purity:98%Color and Shape:SolidMolecular weight:418.92KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Formula:C24H19ClF2N4O3Purity:98%Color and Shape:SolidMolecular weight:484.88KRAS G12D mutation regulator 4
CAS:KRAS G12D mutation regulator 4 can be used in studies about Ras.Formula:C33H33FN6O2Color and Shape:SolidMolecular weight:564.65JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Formula:C21H17ClFN5O2SColor and Shape:SolidMolecular weight:457.91HPK1-IN-10
CAS:HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.Formula:C31H34N6O2Color and Shape:SolidMolecular weight:522.64pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFormula:C34H34F2N4O3Purity:98%Color and Shape:SolidMolecular weight:584.66SOS1-IN-7
CAS:SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).Formula:C23H25F3N4O3Color and Shape:SolidMolecular weight:462.46KRAS G12C mutant protein inhibitor A-1
CAS:KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.Formula:C31H26ClF4N7O2Color and Shape:SolidMolecular weight:640.03KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Formula:C24H21ClFN3O3Purity:97.84%Color and Shape:SolidMolecular weight:453.89K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Formula:C22H23Cl2N3O3Color and Shape:SolidMolecular weight:448.34SOS1-IN-8
CAS:SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).Formula:C24H26F3N3O4Color and Shape:SolidMolecular weight:477.48HPK1-IN-27
CAS:HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.Formula:C26H23F3N4O4Color and Shape:SolidMolecular weight:512.48Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purity:98.00% - 99.71%Color and Shape:SolidMolecular weight:531.31ZG1077
CAS:ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.Formula:C33H33F2N5O5SColor and Shape:SolidMolecular weight:649.71GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H26N8Purity:98%Color and Shape:SolidMolecular weight:438.53pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63SB 203580 sulfone
CAS:SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].Formula:C21H16FN3O2SColor and Shape:SolidMolecular weight:393.43SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Formula:C24H29F2N4O2PColor and Shape:SolidMolecular weight:474.48JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52KRAS G12C inhibitor 35
CAS:KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).Formula:C31H27ClF2N6O3Color and Shape:SolidMolecular weight:605.03MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Formula:C18H22FN3O5SPurity:98%Color and Shape:SolidMolecular weight:411.45AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Formula:C29H29Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:534.48
