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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • KRASG12C IN-13
    Targetmol
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    KRASG12C IN-13

    CAS:
    <p>KRASG12C IN-13 (LY3499446), a potent inhibitor of KRAS G12C, shows potential in the study of advanced solid tumors, specifically non-small cell lung cancer and colorectal cancer.</p>
    Formula:C22H17ClF2N6OS
    Color and Shape:Solid
    Molecular weight:486.93

    Ref: TM-T200083

  • KRAS inhibitor-34
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    KRAS inhibitor-34

    CAS:
    <p>KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.</p>
    Formula:C43H41F3N6O3
    Color and Shape:Solid
    Molecular weight:746.82

    Ref: TM-T200670

  • KRAS G12C inhibitor 33
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    KRAS G12C inhibitor 33

    CAS:
    <p>KRAS G12C inhibitor 33 is a KRAS G12C inhibitor that can be used to study cancer.</p>
    Formula:C30H33N7O3
    Color and Shape:Solid
    Molecular weight:539.63

    Ref: TM-T63807

  • KRAS G12D inhibitor 11
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    KRAS G12D inhibitor 11

    CAS:
    <p>KRAS G12D inhibitor 11 targets KRAS G12D in cancer research (patent WO2021108683A1, compound 52).</p>
    Formula:C29H38BN5O3
    Color and Shape:Solid
    Molecular weight:515.45

    Ref: TM-T63577

  • Refametinib R enantiomer
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    Refametinib R enantiomer

    CAS:
    <p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>
    Formula:C19H20F3IN2O5S
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:572.34

    Ref: TM-T12697

  • 10-Methoxy-canthin-6-one
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    10-Methoxy-canthin-6-one

    CAS:
    <p>10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.</p>
    Formula:C15H10N2O2
    Color and Shape:Solid
    Molecular weight:250.25

    Ref: TM-T200611

  • KRAS G12D inhibitor 9
    Targetmol
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    KRAS G12D inhibitor 9

    CAS:
    <p>KRAS G12D inhibitor 9 targets RAS protein, key in growth, showing promise against KRAS G12D cancer.</p>
    Formula:C33H43N7O2
    Color and Shape:Solid
    Molecular weight:569.74

    Ref: TM-T64031

  • LZTR1-KRAS modulator 1
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    LZTR1-KRAS modulator 1

    CAS:
    <p>LZTR1-KRAS modulator 1 is a regulator of the KRAS-LZTR1 interaction, enhancing the recruitment of the LZTR1-KRAS complex.</p>
    Formula:C11H11Cl2NO
    Color and Shape:Solid
    Molecular weight:244.12

    Ref: TM-T200600

  • KRAS inhibitor-32
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    KRAS inhibitor-32

    CAS:
    <p>KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.</p>
    Formula:C29H35FN10OS2
    Color and Shape:Solid
    Molecular weight:622.78

    Ref: TM-T200688

  • JNK-1-IN-4
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    JNK-1-IN-4

    CAS:
    <p>JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.</p>
    Formula:C22H25BrN6O3
    Color and Shape:Solid
    Molecular weight:501.38

    Ref: TM-T200667

  • KRAS ligand 5
    Targetmol
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    KRAS ligand 5

    CAS:
    <p>KRAS ligand 5 acts as the target protein ligand for PROTACK-Ras Degrader-3, which specifically targets and degrades mutated KRAS proteins.</p>
    Formula:C30H30F2N4O4
    Color and Shape:Solid
    Molecular weight:548.58

    Ref: TM-T200503

  • INS018 055
    Targetmol
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    INS018 055

    CAS:
    <p>INS018 055 (TNIK&amp;amp;MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.</p>
    Formula:C27H30FN7O
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:487.57

    Ref: TM-T87545

  • Emprumapimod
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    Emprumapimod

    CAS:
    <p>Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.</p>
    Formula:C24H29F2N5O3
    Purity:99.21% - >99.99%
    Color and Shape:Solid
    Molecular weight:473.52

    Ref: TM-T63067

  • NDI-101150
    Targetmol
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    NDI-101150

    CAS:
    <p>NDI-101150 (NMBS-2) is an HPK1 inhibitor with antitumor activity, inhibiting BLNK phosphorylation, and used in metastatic solid tumor research.</p>
    Formula:C27H27FN6O2
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:486.54

    Ref: TM-T88840

  • Rineterkib
    Targetmol
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    Rineterkib

    CAS:
    <p>Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.</p>
    Formula:C26H27BrF3N5O2
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:578.42

    Ref: TM-T11224

  • CMK
    Targetmol
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    CMK

    CAS:
    <p>CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.</p>
    Formula:C18H19ClN4O2
    Color and Shape:Solid
    Molecular weight:358.82

    Ref: TM-T10845

    1mg
    Discontinued
    Discontinued product
  • Ravoxertinib hydrochloride
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    Ravoxertinib hydrochloride

    CAS:
    <p>Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).</p>
    Formula:C21H19Cl2FN6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:477.32

    Ref: TM-T15377

    1mg
    Discontinued
    Discontinued product
  • Omtriptolide
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    Omtriptolide

    CAS:
    <p>Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.</p>
    Formula:C24H28O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.479

    Ref: TM-T16390

    1mg
    Discontinued
    Discontinued product
  • MLK-IN-1
    Targetmol
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    MLK-IN-1

    CAS:
    <p>MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.</p>
    Formula:C23H20N4O3S
    Color and Shape:Solid
    Molecular weight:432.5

    Ref: TM-T39102

    ne
    Discontinued
    Discontinued product
  • 2413035-41-1
    Targetmol
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    2413035-41-1

    CAS:
    <p>2413035-41-1 is a useful organic compound for research related to life sciences. The catalog number is T8743 and the CAS number is 2413035-41-1.</p>
    Formula:C51H57F2N9O7S2
    Color and Shape:Solid
    Molecular weight:1010.19

    Ref: TM-T8743

    ne
    Discontinued
    Discontinued product