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ERK

ERK

ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.

Found 193 products of "ERK"

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  • KRAS G12C inhibitor 61
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    KRAS G12C inhibitor 61

    CAS:
    <p>KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.</p>
    Formula:C31H33ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:590.09

    Ref: TM-T79808

  • K145 hydrochloride
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    K145 hydrochloride

    CAS:
    <p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>
    Formula:C18H25ClN2O3S
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:384.92

    Ref: TM-TQ0138

  • (R)-VX-11e
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    (R)-VX-11e

    CAS:
    <p>(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.</p>
    Formula:C24H20Cl2FN5O2
    Purity:98.73%
    Color and Shape:Solid
    Molecular weight:500.35

    Ref: TM-T78143

  • DL-threo dihydrosphingosine
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    DL-threo dihydrosphingosine

    CAS:
    <p>DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.</p>
    Formula:C18H39NO2
    Color and Shape:Solid
    Molecular weight:301.51

    Ref: TM-T27189

  • Inflachromene
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    Inflachromene

    CAS:
    <p>Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.</p>
    Formula:C21H19N3O4
    Purity:97.36% - 99.88%
    Color and Shape:Solid
    Molecular weight:377.39

    Ref: TM-T24167

  • CymitQuimica logo
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    CXJ-2

    CAS:
    <p>CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.</p>
    Formula:C55H87N15O22
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1310.37

    Ref: TM-T74782

  • ERK1/2 inhibitor 5
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    ERK1/2 inhibitor 5

    CAS:
    <p>ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.</p>
    Formula:C28H32ClFN6O5
    Color and Shape:Solid
    Molecular weight:587.04

    Ref: TM-T64155

  • ERK1/2 inhibitor 7
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    ERK1/2 inhibitor 7

    CAS:
    <p>ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).</p>
    Formula:C23H22FN7OS
    Color and Shape:Solid
    Molecular weight:463.53

    Ref: TM-T62933

  • EVT801
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    EVT801

    CAS:
    <p>EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.</p>
    Formula:C19H21N5O3
    Purity:97.4%
    Color and Shape:Solid
    Molecular weight:367.4

    Ref: TM-T73516

  • ERK-IN-2 free base
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    ERK-IN-2 free base

    CAS:
    <p>ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at &gt;10 μM.</p>
    Formula:C16H17N5O2
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T72517

  • Laxiflorin B
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    Laxiflorin B

    CAS:
    <p>Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].</p>
    Formula:C20H24O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:344.4

    Ref: TM-T79785

  • JWG-071
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    JWG-071

    CAS:
    <p>JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.</p>
    Formula:C34H44N8O3
    Purity:98.33%
    Color and Shape:Solid
    Molecular weight:612.77

    Ref: TM-T14547

  • MK-8353
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    MK-8353

    CAS:
    <p>MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)</p>
    Formula:C37H41N9O3S
    Purity:96.15% - 97.19%
    Color and Shape:Solid
    Molecular weight:691.84

    Ref: TM-T12069

  • ERK1/2 inhibitor 6
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    ERK1/2 inhibitor 6

    CAS:
    <p>ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.</p>
    Formula:C27H29ClFN7O5
    Color and Shape:Solid
    Molecular weight:586.01

    Ref: TM-T64147

  • DOR agonist 2
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    DOR agonist 2

    CAS:
    <p>Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.</p>
    Formula:C29H26N2O3
    Color and Shape:Solid
    Molecular weight:450.53

    Ref: TM-T200382

  • ERK2 IN-1
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    ERK2 IN-1

    CAS:
    <p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>
    Formula:C36H34FN7O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:647.76

    Ref: TM-T11228

  • ATX inhibitor 26
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    ATX inhibitor 26

    CAS:
    <p>ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.</p>
    Formula:C18H19Cl2N7O3
    Color and Shape:Solid
    Molecular weight:452.30

    Ref: TM-T207167

  • AL 8810
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    AL 8810

    CAS:
    <p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>
    Formula:C24H31FO4
    Color and Shape:Solid
    Molecular weight:402.5

    Ref: TM-T21752

  • SOS1 activator 2
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    SOS1 activator 2

    CAS:
    <p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>
    Formula:C26H28ClFN6
    Color and Shape:Solid
    Molecular weight:478.992

    Ref: TM-T204838

  • KRASG12C IN-15
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    KRASG12C IN-15

    CAS:
    <p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>
    Formula:C31H32FN3O2
    Color and Shape:Solid
    Molecular weight:497.603

    Ref: TM-T205541