ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 217 products of "ERK"
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Triptonide
CAS:Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.Formula:C20H22O6Purity:99.11% - 99.64%Color and Shape:White Crystalline PowderMolecular weight:358.39Ref: TM-T5S1058
1mg52.00€2mg74.00€5mg108.00€1mL*10mM (DMSO)133.00€10mg158.00€25mg268.00€50mg409.00€100mg595.00€200mg833.00€SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Formula:C23H29ClN8O2Purity:98.24%Color and Shape:SolidMolecular weight:484.98ERK-IN-4
CAS:ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Formula:C14H17ClN2O3SPurity:98.92% - 99.84%Color and Shape:SolidMolecular weight:328.814Ref: TM-T36675
1mg46.00€2mg57.00€5mg93.00€1mL*10mM (DMSO)99.00€10mg137.00€25mg219.00€50mg324.00€100mg484.00€Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purity:99.85%Color and Shape:SolidMolecular weight:469.79PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColor and Shape:SolidMolecular weight:296.11ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Color and Shape:SolidMolecular weight:505.442,5-Dihydroxybiphenyl
CAS:2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.
Formula:C12H10O2Purity:99.66%Color and Shape:White To Grey-Brownish PowderMolecular weight:186.21D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.4ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Color and Shape:SolidMolecular weight:381.19CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Formula:C22H17Cl2FN4O2Color and Shape:SolidMolecular weight:459.3Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurity:98.31%Color and Shape:SolidMolecular weight:454.53Ref: TM-T62798
1mg130.00€5mg313.00€1mL*10mM (DMSO)341.00€10mg497.00€25mg982.00€50mg1,603.00€100mg2,592.00€ERK1/2 inhibitor 1
CAS:ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
Formula:C29H32ClN5O4Purity:98.81%Color and Shape:SolidMolecular weight:550.05Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Color and Shape:SolidMolecular weight:326.35GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purity:98%Color and Shape:SolidMolecular weight:304.38GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColor and Shape:SolidMolecular weight:462.47BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purity:98%Color and Shape:SolidMolecular weight:282.29UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Color and Shape:SolidMolecular weight:403.9VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Formula:C19H19FN2O2Color and Shape:SolidMolecular weight:326.36mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purity:99.26%Color and Shape:SolidMolecular weight:1948.31ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Color and Shape:SolidMolecular weight:489.37Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formula:C8H16O2S2Purity:97.51%Color and Shape:Yellow To Orange LiquidMolecular weight:208.34PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Formula:C22H16F2N4O2Purity:98%Color and Shape:SolidMolecular weight:406.38Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColor and Shape:SolidMolecular weight:456.89Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColor and Shape:SolidMolecular weight:276.13(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purity:98.09%Color and Shape:SolidMolecular weight:304.38Ref: TM-T11137
1mg77.00€1mL*10mM (DMSO)153.00€5mg158.00€10mg225.00€25mg338.00€50mg472.00€100mg645.00€ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purity:99.71% - 99.95%Color and Shape:SolidMolecular weight:344.37Ref: TM-T61122
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purity:99.75%Color and Shape:SolidMolecular weight:330.092RLX-33
CAS:RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.Formula:C24H19ClN4O4Purity:99.89%Color and Shape:SolidMolecular weight:462.89ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34K145 hydrochloride
CAS:K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.Formula:C18H25ClN2O3SPurity:99.8%Color and Shape:SolidMolecular weight:384.92ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purity:98%Color and Shape:SolidMolecular weight:586.08DL-threo dihydrosphingosine
CAS:DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.Formula:C18H39NO2Color and Shape:SolidMolecular weight:301.51Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Formula:C21H19N3O4Purity:97.36% - 99.88%Color and Shape:SolidMolecular weight:377.39Ref: TM-T24167
1mg109.00€5mg260.00€1mL*10mM (DMSO)286.00€10mg416.00€25mg710.00€50mg973.00€100mg1,314.00€MRS2693 trisodium
CAS:MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].Formula:C9H10IN2Na3O12P2Color and Shape:SolidMolecular weight:596PF-07284892
CAS:PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.Formula:C21H22ClN7SPurity:97.77%Color and Shape:SolidMolecular weight:439.96(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purity:98.73%Color and Shape:SolidMolecular weight:500.35ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Formula:C18H12N6OColor and Shape:SolidMolecular weight:328.33CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purity:98%Color and Shape:SolidMolecular weight:1310.37KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:590.09ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formula:C23H22FN7OSColor and Shape:SolidMolecular weight:463.53I-287
CAS:I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.Formula:C30H30ClFN4O4Color and Shape:SolidMolecular weight:565.04EVT801
CAS:EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formula:C19H21N5O3Purity:97.4%Color and Shape:SolidMolecular weight:367.4Ref: TM-T73516
1mg154.00€5mg371.00€1mL*10mM (DMSO)409.00€10mg595.00€25mg1,251.00€50mg1,963.00€100mg3,132.00€SKI2496
CAS:SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formula:C35H36F7N5O5Color and Shape:SolidMolecular weight:739.68Firazorexton hydrate
CAS:Firazorexton hydrate (TAK-994) is a brain-penetrant and orally active agonist of the orexin type 2 receptor (OX2R) with a potent EC50 of 19 nM.Formula:C22H25F3N2O4SH2OColor and Shape:SolidMolecular weight:497.53ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formula:C28H32ClFN6O5Color and Shape:SolidMolecular weight:587.04Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Formula:C20H24O5Purity:98%Color and Shape:SolidMolecular weight:344.4MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFormula:C18H20FN3O4SPurity:98%Color and Shape:SolidMolecular weight:393.43ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Formula:C23H20ClN7O2SColor and Shape:SolidMolecular weight:493.97MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formula:C37H41N9O3SPurity:96.15% - 97.19%Color and Shape:SolidMolecular weight:691.84Ref: TM-T12069
1mg77.00€2mg92.00€5mg147.00€1mL*10mM (DMSO)217.00€10mg258.00€25mg557.00€50mg888.00€100mg1,341.00€ERK2 IN-1
CAS:ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.Formula:C36H34FN7O2SPurity:98%Color and Shape:SolidMolecular weight:647.76
