ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 229 products for "ERK".
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ERK1/2 inhibitor 6
CAS:ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.Formula:C27H29ClFN7O5Color and Shape:SolidMolecular weight:586.01ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formula:C28H31ClFN5O6SColor and Shape:SolidMolecular weight:620.09DOR agonist 2
CAS:Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formula:C29H26N2O3Color and Shape:SolidMolecular weight:450.53Anti-aging agent 1
CAS:Anti-aging agent 1 (compound 24), a piperlongumine (PL) derivative, demonstrates a significant enhancement in senolytic activity, being 50 times more effective against senescent WI-38 fibroblasts than PL [1].Formula:C16H16ClNO3Molecular weight:305.76KRAS G12C-IN-78
CAS:KRAS G12C-IN-77 is a selective dual-state covalent inhibitor for KRASG12C, capable of binding with high affinity to the GDP-bound (inactive state) [IC50= 7 nM] and GTP-bound (active state) [IC50= 4 nM] forms of KRASG12C. It swiftly inhibits ERK1/2 phosphorylation, induces covalent adduct formation with endogenous KRASG12C, suppresses MAPK pathway gene expression, and inhibits the proliferation of KRASG12C-mutant cells. KRAS G12C-IN-77 is applicable in research concerning KRASG12C-mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer.Formula:C37H31F4N7O3SMolecular weight:729.75Glutathione trisulfide
CAS:Glutathione trisulfide (GSSSG) is a potent neuroprotective agent with anti-inflammatory properties. It inhibits lipopolysaccharide (LPS)-induced inflammatory gene expression in retinal pigment epithelial cells through excessive activation of the ERK signaling pathway, independently of the NRF2/HMOX1 pathway. GSSSG is applicable in research on neurodegenerative diseases and ischemic spinal cord injury (SCI).Formula:C20H32N6O12S3Molecular weight:644.69ATX inhibitor 26
CAS:ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.Formula:C18H19Cl2N7O3Color and Shape:SolidMolecular weight:452.30D-DT/MIF-1-IN-1
CAS:D-DT/MIF-1-IN-1 (Compound 4h) is a non-competitive, non-covalent inhibitor of MIF-1 and D-DT, exhibiting IC50 values of 2.4 μM and 4.0 μM for D-DT, and 9.8 μM for MIF-1. It inhibits ERK phosphorylation induced by D-DT and demonstrates antiproliferative activity in non-small cell lung cancer cells.Formula:C12H10ClNO3Molecular weight:251.67Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Formula:C26H27BrF3N5O2Purity:99.73%Color and Shape:SolidMolecular weight:578.42Ref: TM-T11224
1mg87.00€5mg170.00€1mL*10mM (DMSO)224.00€10mg318.00€25mg538.00€50mg765.00€100mg1,035.00€
