CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Found 66 products for "CFTR".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Formula:C16H16F3N3O5SPurity:99.13%Color and Shape:White SolidMolecular weight:419.38Ref: TM-T13705
1mg98.00€5mg234.00€1mL*10mM (DMSO)258.00€10mg358.00€25mg737.00€50mg1,099.00€100mg1,468.00€(R)-Posenacaftor sodium
CAS:(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505Posenacaftor
CAS:Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.Formula:C27H27NO5Color and Shape:SolidMolecular weight:445.51GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Formula:C30H37F3N2O6Purity:98%Color and Shape:SolidMolecular weight:578.62Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Formula:C28H32F3N5O4SPurity:99.71%Color and Shape:SolidMolecular weight:591.65Ref: TM-T30293
1mg334.00€5mg802.00€10mg1,099.00€1mL*10mM (DMSO)1,161.00€25mg1,611.00€50mg2,187.00€100mg2,952.00€PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Formula:C28H29N3O2Purity:99.79%Color and Shape:SolidMolecular weight:439.55Ref: TM-T16516
1mg55.00€1mL*10mM (DMSO)144.00€5mg148.00€10mg215.00€25mg344.00€50mg465.00€100mg630.00€200mg850.00€Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Formula:C27H28ClFN2OSPurity:97.79% - 98.55%Color and Shape:SolidMolecular weight:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Formula:C27H34N4O4SPurity:99.15% - 99.58%Color and Shape:SolidMolecular weight:510.65UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Formula:C14H8ClF3N2OPurity:99.82%Color and Shape:SolidMolecular weight:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Formula:C16H14N2OPurity:99.88% - 99.93%Color and Shape:SolidMolecular weight:250.3Ref: TM-T29114
1mg70.00€1mL*10mM (DMSO)138.00€5mg156.00€10mg225.00€25mg371.00€50mg504.00€100mg662.00€200mg875.00€CFTR corrector 8
CAS:CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Formula:C29H27F2NO7Purity:99.57%Color and Shape:White SolidMolecular weight:539.52Ref: TM-T63806
1mg34.00€5mg78.00€1mL*10mM (DMSO)90.00€10mg109.00€25mg212.00€50mg334.00€100mg548.00€200mg737.00€Chromanol 293B
CAS:Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.Formula:C15H20N2O4SPurity:99.78%Color and Shape:White SolidMolecular weight:324.4(R)-Elexacaftor
CAS:(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.Formula:C26H34F3N7O4SPurity:98.99%Color and Shape:SolidMolecular weight:597.65Ref: TM-T78240
1mg92.00€5mg230.00€1mL*10mM (DMSO)304.00€10mg371.00€25mg712.00€50mg1,009.00€100mg1,378.00€CRF1 receptor antagonist-1
CAS:CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].Formula:C27H28ClFN2O2SPurity:98%Color and Shape:SolidMolecular weight:499.04CFTR corrector 6
CAS:CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.Formula:C22H13F4N9Color and Shape:SolidMolecular weight:479.39CFTR corrector 12
CAS:CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.Formula:C19H21ClN4O2S2Purity:99.47%Color and Shape:SolidMolecular weight:436.98DNDS
CAS:DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Formula:C14H8N2Na2O10S2Purity:99.92%Color and Shape:Yellow SolidMolecular weight:474.33BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Formula:C26H18BrN3O6Purity:97.67% - 98.86%Color and Shape:SolidMolecular weight:548.34Ref: TM-T10591
1mg44.00€5mg111.00€1mL*10mM (DMSO)128.00€10mg166.00€25mg265.00€50mg388.00€100mg535.00€200mg718.00€(R)-Vanzacaftor
CAS:(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].Formula:C32H39N7O4SColor and Shape:SolidMolecular weight:617.76CFTR corrector 4
CAS:Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Formula:C29H27F2NO7Purity:99.32%Color and Shape:White SolidMolecular weight:539.52Ref: TM-T10776
1mg46.00€5mg100.00€1mL*10mM (DMSO)119.00€10mg156.00€25mg304.00€50mg429.00€100mg610.00€
