Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Found 276 products of "Potassium Channel"
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BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Formula:C174H261N51O52S6Purity:98%Color and Shape:SolidMolecular weight:4091.65Dendrotoxin K
CAS:<p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>Formula:C294H462N84O75S6Color and Shape:SolidMolecular weight:6559.66MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Formula:C22H21N7O3SColor and Shape:SolidMolecular weight:463.512Guangxitoxin 1E
CAS:<p>Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.</p>Formula:C178H248N44O45S7Purity:98%Color and Shape:SolidMolecular weight:3948.61Phe-Met-Arg-Phe, amide
CAS:<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Formula:C29H42N8O4SPurity:98%Color and Shape:SolidMolecular weight:598.76Lei-Dab7
CAS:<p>Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.</p>Formula:C141H236N46O39S6Purity:98%Color and Shape:SolidMolecular weight:3392.06GsAF-II
<p>GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium</p>Formula:C176H261N47O45S7Purity:98%Color and Shape:SolidMolecular weight:3979.7Potassium Channel Targeted Library
<p>A unique collection of xnum potassium channel blockers and agonists for high throughput and high content screening;</p>Color and Shape:Odour SolidHeteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Formula:C168H238N46O51S6Purity:98%Color and Shape:SolidMolecular weight:3910.35Guanfu base A
CAS:<p>Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.</p>Formula:C24H31NO6Purity:99.71% - 99.85%Color and Shape:SolidMolecular weight:429.5AmmTX3
<p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>Formula:C158H262N50O48S6Purity:98%Color and Shape:SolidMolecular weight:3822.47HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Formula:C337H503N103O97S6Molecular weight:7736.59176GsAF-I
<p>GsAF-I is a potent blocker of Na_v and hERG1 channels, exhibiting half-maximal inhibitory concentrations (IC50s) of 0.36 μM (Na_v 1.1), 0.6 μM (Na_v 1.2), 1.28</p>Formula:C160H244N46O42S7Purity:98%Color and Shape:SolidMolecular weight:3708.39Aekatperone
<p>Aekatperone, a reversible KATP channel inhibitor, exhibits an IC50 of 9 μM. It is utilized in research related to congenital hyperinsulinism (CHI).</p>Formula:C20H25N5O2SColor and Shape:SolidMolecular weight:399.51Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Formula:C19H23F2N3O2Color and Shape:SolidMolecular weight:363.4BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formula:C22H23F7N2O3Color and Shape:SolidMolecular weight:496.418RU-TRAAK-2
CAS:<p>RU-TRAAK-2 reversibly inhibits TWIK-related K+ channel, inactive on Kv1.2, GIRK2, Slo1.</p>Formula:C19H17N3OSPurity:99.81%Color and Shape:SolidMolecular weight:335.42Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formula:C169H278N54O48S8Purity:98%Color and Shape:SolidMolecular weight:4090.87Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formula:C79H131N31O24S4Purity:98%Color and Shape:SolidMolecular weight:2027.34ADWX 1
<p>Potent KV1.3 blocker, IC50: 0.0019 nM; less effective on KV1.1. Curbs CD4+ T cell activation; eases rat multiple sclerosis model.</p>Formula:C169H281N57O46S7Purity:98%Color and Shape:SolidMolecular weight:4071.86
