
Potassium Channel
Potassium channels are a diverse group of membrane proteins that facilitate the flow of potassium ions (K+) across the cell membrane. These channels play a crucial role in maintaining the resting membrane potential, regulating cell volume, and controlling the excitability of neurons and muscle cells. Potassium channels are involved in various physiological processes, including cardiac rhythm regulation, insulin secretion, and neurotransmitter release. Dysregulation of potassium channels is linked to conditions such as arrhythmias, epilepsy, and hypertension. At CymitQuimica, we offer a wide range of potassium channel modulators to support your research in electrophysiology, cardiovascular health, and neurobiology.
Found 276 products of "Potassium Channel"
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BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Formula:C22H23F7N2O3Color and Shape:SolidMolecular weight:496.418Agitoxin-2
CAS:<p>Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).</p>Formula:C169H278N54O48S8Purity:98%Color and Shape:SolidMolecular weight:4090.87Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Formula:C17H19F2N3O2Color and Shape:SolidMolecular weight:335.349Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Formula:C79H131N31O24S4Purity:98%Color and Shape:SolidMolecular weight:2027.34MASP-2-IN-1
<p>MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.</p>Formula:C22H21N7O3SColor and Shape:SolidMolecular weight:463.512Margatoxin
CAS:<p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.</p>Formula:C178H286N52O50S7Purity:98%Color and Shape:SolidMolecular weight:4178.96Charybdotoxin
CAS:<p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>Formula:C176H277N57O55S7Purity:98%Color and Shape:SolidMolecular weight:4295.95KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Formula:C22H23N3O4S2Purity:99.71%Color and Shape:SolidMolecular weight:457.57Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Formula:C16H18N2O3Purity:99.39%Color and Shape:SolidMolecular weight:286.33Neosolaniol
CAS:<p>Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.</p>Formula:C19H26O8Purity:98%Color and Shape:SolidMolecular weight:382.4Endoxifen Z-isomer hydrochloride
CAS:<p>Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.</p>Formula:C25H28ClNO2Color and Shape:SolidMolecular weight:409.95Nateglinide D5
CAS:<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Formula:C19H27NO3Purity:98%Color and Shape:SolidMolecular weight:322.45Clamikalant sodium
CAS:<p>Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.</p>Formula:C19H21ClN3NaO5S2Purity:99.95%Color and Shape:SolidMolecular weight:493.96Flecainide
CAS:<p>Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.</p>Formula:C17H20F6N2O3Purity:99.896%Color and Shape:SolidMolecular weight:414.34QO-58
CAS:<p>QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain</p>Formula:C18H8Cl2F4N4OPurity:99.17%Color and Shape:SolidMolecular weight:443.18Almitrine mesylate
CAS:<p>Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.</p>Formula:C28H37F2N7O6S2Purity:99.96%Color and Shape:CoaMolecular weight:669.76TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Formula:C18H14ClN3O2SPurity:99.47%Color and Shape:SolidMolecular weight:371.84Kv2-IN-A1
CAS:<p>Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.</p>Formula:C20H17ClN4OSPurity:98.83%Color and Shape:SolidMolecular weight:396.89E-4031 dihydrochloride
CAS:<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44Amifampridine
CAS:<p>Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.</p>Formula:C5H7N3Purity:99.82%Color and Shape:Slightly Beige PowderMolecular weight:109.13
