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Na-K-Cl cotransporter

Na-K-Cl cotransporter

The Na-K-Cl cotransporter is a membrane protein that plays a pivotal role in maintaining the electrolyte balance and cell volume by moving sodium, potassium, and chloride ions across the cell membrane. It is especially important in the functioning of kidney cells, where it contributes to the regulation of blood pressure and fluid balance. Dysregulation of this transporter is associated with hypertension, renal disorders, and neurological conditions. At CymitQuimica, we offer a range of modulators targeting the Na-K-Cl cotransporter to support your research in nephrology, cardiovascular health, and ion homeostasis.

Found 8 products of "Na-K-Cl cotransporter"

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  • Azosemide
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    Azosemide

    CAS:
    <p>Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).</p>
    Formula:C12H11ClN6O2S2
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:370.84

    Ref: TM-T10441

  • Torsemide
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    Torsemide

    CAS:
    <p>Torsemide (AC-4464), a sulfonylurea loop diuretic, has a long action duration, high plasma protein binding, and a long half-life.</p>
    Formula:C16H20N4O3S
    Purity:99.81%
    Color and Shape:Crystalline Solid
    Molecular weight:348.42

    Ref: TM-T1410

  • Bumetanide
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    Bumetanide

    CAS:
    <p>Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.</p>
    Formula:C17H20N2O5S
    Purity:99.82% - 99.9%
    Color and Shape:Solid
    Molecular weight:364.42

    Ref: TM-T0108

  • KCC2 potentiators-1
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    KCC2 potentiators-1

    CAS:
    <p>Compound 2, known as KCC2 potentiators-1, acts as an enhancer of the potassium chloride cotransporter-2 (KCC2). It holds potential for applications in studies related to neurological disorders.</p>
    Formula:C15H17N3OS
    Color and Shape:Solid
    Molecular weight:287.38

    Ref: TM-T203414

  • Piretanide
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    Piretanide

    CAS:
    <p>Piretanide, an oral loop diuretic, effective and potassium-sparing, heart failure and hypertension with reduced electrolyte imbalance risk.</p>
    Formula:C17H18N2O5S
    Color and Shape:Pale Yellow Powder
    Molecular weight:362.4

    Ref: TM-T19788

  • ZT-1a
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    ZT-1a

    CAS:
    <p>ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders.</p>
    Formula:C22H15Cl3N2O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:445.73

    Ref: TM-T39566

  • Bumetanide-d5
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    Bumetanide-d5

    CAS:
    <p>Bumetanide D5 is a deuterium-labeled Bumetanide. Bumetanide is a Na+-K+-Cl- (NKCC1) inhibitor (IC50s: 0.68 and 4.0 μM for hNKCC1A and hNKCC2A).</p>
    Formula:C17H20N2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.45

    Ref: TM-T10633

  • Bumetanide sodium
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    Bumetanide sodium

    CAS:
    <p>Bumetanide sodium, a potent diuretic, blocks NKCC1 (IC50: 0.68 μM) and NKCC2 (IC50: 4.0 μM).</p>
    Formula:C17H19N2NaO5S
    Color and Shape:Solid
    Molecular weight:386.4

    Ref: TM-T61713

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