Na-K-Cl cotransporter
The Na-K-Cl cotransporter is a membrane protein that plays a pivotal role in maintaining the electrolyte balance and cell volume by moving sodium, potassium, and chloride ions across the cell membrane. It is especially important in the functioning of kidney cells, where it contributes to the regulation of blood pressure and fluid balance. Dysregulation of this transporter is associated with hypertension, renal disorders, and neurological conditions. At CymitQuimica, we offer a range of modulators targeting the Na-K-Cl cotransporter to support your research in nephrology, cardiovascular health, and ion homeostasis.
Found 9 products for "Na-K-Cl cotransporter".
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Azosemide
CAS:Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).Formula:C12H11ClN6O2S2Purity:99.84%Color and Shape:SolidMolecular weight:370.84Torsemide
CAS:Torsemide (AC-4464), a sulfonylurea loop diuretic, has a long action duration, high plasma protein binding, and a long half-life.Formula:C16H20N4O3SPurity:99.81%Color and Shape:SolidMolecular weight:348.42Bumetanide
CAS:Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.Formula:C17H20N2O5SPurity:99.82% - 99.90%Color and Shape:White SolidMolecular weight:364.42Torsemide (Standard)
CAS:Torsemide (Standard) is the standard substance of Torsemide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.Formula:C16H20N4O3SColor and Shape:SolidMolecular weight:348.42Piretanide
CAS:Piretanide, an oral loop diuretic, effective and potassium-sparing, heart failure and hypertension with reduced electrolyte imbalance risk.Formula:C17H18N2O5SColor and Shape:Yellow SolidMolecular weight:362.4ZT-1a
CAS:ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders.Formula:C22H15Cl3N2O2Purity:99.74%Color and Shape:SolidMolecular weight:445.73Bumetanide-D5
CAS:Bumetanide D5 is a deuterium-labeled Bumetanide. Bumetanide is a Na+-K+-Cl- (NKCC1) inhibitor (IC50s: 0.68 and 4.0 μM for hNKCC1A and hNKCC2A).Formula:C17H20N2O5SPurity:98%Color and Shape:SolidMolecular weight:369.45KCC2 potentiators-1
CAS:Compound 2, known as KCC2 potentiators-1, acts as an enhancer of the potassium chloride cotransporter-2 (KCC2). It holds potential for applications in studies related to neurological disorders.Formula:C15H17N3OSColor and Shape:SolidMolecular weight:287.38ARN23746
CAS:ARN23746 (IAMA-6) is a selective NKCC1 inhibitor with neuroprotective activity, used in brain disease research (e.g., drug-resistant epilepsy, ASD, Down syndrome).Formula:C17H25F3N2O4SPurity:99.92%Color and Shape:White SolidMolecular weight:410.45
