Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Found 259 products of "Sodium Channel"
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Nav1.8-IN-14
CAS:Nav1.8-IN-14 (compound 20) is an effective selective inhibitor of Nav1.8. It is utilized in the research of pain-associated diseases.Formula:C18H17F5N4O3SColor and Shape:SolidMolecular weight:464.41Pentisomide
CAS:Controlled ProductApplications Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).
References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992), Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)Formula:C19H33N3OColor and Shape:NeatMolecular weight:319.483-Deoxyyunaconitine
CAS:Controlled ProductApplications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.
References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),Formula:C35H49NO10Color and Shape:NeatMolecular weight:643.761,2,4-Oxadiazol-3-amine
CAS:Controlled ProductApplications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.
Formula:C2H3N3OColor and Shape:NeatMolecular weight:85.06N-Formylguanidine
CAS:Controlled ProductFormula:C2H5N3OColor and Shape:Off-WhiteMolecular weight:87.086-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Controlled ProductApplications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.
References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),Formula:C17H28N2O2Color and Shape:NeatMolecular weight:292.4163-Hydroxy-4-phenylbenzoic Acid
CAS:Controlled ProductApplications 3-Hydroxy-4-phenylbenzoic Acid is a useful reagent for the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channel.
References Hadida Ruah, S. S., et al.: U.S. Pat. Appl. Publ. (2012), US 20120196869 A1Formula:C13H10O3Color and Shape:NeatMolecular weight:214.22Clopamide
CAS:Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Formula:C14H20ClN3O3SPurity:99.71%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:345.84Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formula:C16H17BrClN3O3Purity:99.53%Color and Shape:Off-White SolidMolecular weight:414.68Ref: TM-T6856
1mg34.00€5mg82.00€10mg116.00€25mg227.00€50mg344.00€100mg517.00€500mg1,134.00€1mL*10mM (DMSO)92.00€ATX-II TFA
ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata).Purity:98%Color and Shape:Odour SolidGDC-0276
CAS:GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.Formula:C24H31FN2O4SPurity:99.77%Color and Shape:SolidMolecular weight:462.58GX-936
CAS:GX-936, Selective Nav1.7 inhibitor, binds activated VSD4 to oppose inactivation, for pain perception research.Formula:C24H20F3N7O3S2Purity:98.04%Color and Shape:SolidMolecular weight:575.59GNE-0439
CAS:GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.Formula:C21H31NO3Purity:99.60%Color and Shape:SolidMolecular weight:345.48Ref: TM-T11437
1mg154.00€5mg371.00€10mg620.00€25mg1,305.00€50mg1,783.00€100mg2,250.00€1mL*10mM (DMSO)409.00€(5R)-BW-4030W92
CAS:(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.Formula:C11H9Cl2FN4Purity:98.27%Color and Shape:SolidMolecular weight:287.12PF 05089771 tosylate
CAS:PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.Formula:C18H12Cl2FN5O3S2·C7H8O3SPurity:98.55%Color and Shape:SolidMolecular weight:672.56Sodium Channel inhibitor 2
CAS:Sodium Channel inhibitor 2 is a blocker of sodium channel.Formula:C26H25Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:466.4E 0747
CAS:E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.
Formula:C21H28ClN3O4Purity:95.17%Color and Shape:SolidMolecular weight:421.92GX-674
CAS:GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study ofFormula:C21H13ClF2N6O3S2Purity:98.60%Color and Shape:SolidMolecular weight:534.95DPI 201-106
CAS:DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.Formula:C29H30N4O2Purity:99.94%Color and Shape:SolidMolecular weight:466.57NHE3-IN-2
CAS:NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.Formula:C15H12ClN5Color and Shape:SolidMolecular weight:297.74Halofuginone hydrobromide
CAS:Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.Formula:C16H17BrClN3O3·HBrPurity:97.01% - 99.73%Color and Shape:SolidMolecular weight:495.59Ref: TM-T3524
1mg34.00€2mg49.00€5mg74.00€10mg106.00€25mg207.00€50mg310.00€100mg469.00€500mg897.00€1mL*10mM (DMSO)84.00€Nav1.7 inhibitor
CAS:Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.Formula:C15H11Cl3FNO4SPurity:97.52%Color and Shape:SolidMolecular weight:426.68Ref: TM-T12184
1mg42.00€2mg55.00€5mg89.00€10mg135.00€25mg264.00€50mg423.00€100mg677.00€1mL*10mM (DMSO)87.00€Relutrigine
CAS:Relutrigine, Oral sodium current inhibitor, suppresses sustained INa (SCN8A mutations), reduces neuronal excitability, for anticonvulsant therapy.Formula:C15H11F6N5O2Purity:99.68%Color and Shape:SolidMolecular weight:407.27Ref: TM-T69652
1mg260.00€5mg650.00€10mg1,009.00€25mg1,504.00€50mg1,963.00€100mg2,520.00€1mL*10mM (DMSO)583.00€Nav1.1 activator 1
CAS:Nav1.1 activator 1, Selective Nav1.1 agonist, BBB permeable, increases current decay time, for central nervous system disorder research.Formula:C24H23F3N4OPurity:99.99%Color and Shape:SolidMolecular weight:440.46Ref: TM-T12179
1mg99.00€5mg249.00€10mg386.00€25mg758.00€50mg1,180.00€100mg1,848.00€1mL*10mM (DMSO)272.00€GX-585
CAS:GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.Formula:C24H25Cl2FN4O3SPurity:99.02% - 99.03%Color and Shape:SolidMolecular weight:539.45Phenamil
CAS:Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.Formula:C12H12ClN7OPurity:99.07%Color and Shape:SolidMolecular weight:305.72Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Formula:C15H25ClFNSiPurity:99.97%Color and Shape:SolidMolecular weight:301.9Elpetrigine
CAS:Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.Formula:C10H7Cl3N4Purity:99.04% - 99.43%Color and Shape:SolidMolecular weight:289.55NaV1.2/1.6 channel blocker-1
CAS:NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.Formula:C14H14N2OSPurity:99.54%Color and Shape:SolidMolecular weight:258.34NHE3-IN-1
CAS:NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。Formula:C12H10ClN3SPurity:99.93%Color and Shape:SolidMolecular weight:263.75TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Formula:C25H27F3N6O3Purity:99.71%Color and Shape:SolidMolecular weight:516.52Ref: TM-T23439
1mg34.00€5mg75.00€10mg111.00€25mg245.00€50mg363.00€100mg515.00€200mg702.00€1mL*10mM (DMSO)84.00€KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Formula:C13H12FN3O2Purity:99.91%Color and Shape:SolidMolecular weight:261.25Ralitoline
CAS:Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.Formula:C13H13ClN2O2SPurity:98.45%Color and Shape:SolidMolecular weight:296.77Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFormula:C17H21NO2·HClPurity:99.21%Color and Shape:White SolidMolecular weight:307.826-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Formula:C6H8IN7OPurity:98%Color and Shape:SolidMolecular weight:321.08SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Formula:C19H19Cl3N2O3SPurity:99.67%Color and Shape:SolidMolecular weight:461.79Ref: TM-T12931
1mg48.00€5mg92.00€10mg152.00€25mg268.00€50mg447.00€100mg623.00€200mg883.00€500mg1,305.00€1mL*10mM (DMSO)114.00€Aneratrigine
CAS:Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].Formula:C19H20ClF2N5O2S2Purity:98%Color and Shape:SolidMolecular weight:487.97PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Formula:C17H16ClN5O2Purity:99.85%Color and Shape:SolidMolecular weight:357.79(Rac)-AMG8379
CAS:(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.Formula:C25H16ClF2N3O5SPurity:99.6%Color and Shape:SolidMolecular weight:543.93Ref: TM-T12655
1mg175.00€2mg264.00€5mg404.00€10mg592.00€25mg888.00€50mg1,243.00€100mg1,701.00€500mg3,402.00€1mL*10mM (DMSO)512.00€Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Formula:C14H12FN3O2Purity:99.82%Color and Shape:SolidMolecular weight:273.26GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Formula:C25H29Cl2FN2O4SPurity:99.877%Color and Shape:SolidMolecular weight:543.48Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Formula:C19H18ClN3O4S2Purity:98%Color and Shape:SolidMolecular weight:451.95Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Formula:C22H14F3NO5Purity:99.91%Color and Shape:SolidMolecular weight:429.35Ref: TM-T15358
1mg120.00€5mg289.00€10mg439.00€25mg708.00€50mg954.00€100mg1,288.00€1mL*10mM (DMSO)318.00€Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Formula:C19H21Cl2F2N5O2S2Purity:98.37% - 99.16%Color and Shape:SolidMolecular weight:524.43VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Formula:C12H12F3N3OSPurity:99.88%Color and Shape:SolidMolecular weight:303.3Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Formula:C20H20ClN3O2Color and Shape:SolidMolecular weight:369.845Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formula:C22H27Cl2F2N3O2SColor and Shape:SolidMolecular weight:506.44(R)-Duloxetine
CAS:(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.Formula:C18H19NOSColor and Shape:SolidMolecular weight:297.42Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formula:C25H35BrN2Color and Shape:SolidMolecular weight:443.463PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Formula:C17H16N4O3S2Color and Shape:SolidMolecular weight:388.46LBA-3
CAS:LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA)-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].Formula:C18H18O5Color and Shape:SolidMolecular weight:314.33Vormatrigine
CAS:Vormatrigine effectively inhibits sodium channels (sodium channel).Formula:C16H12F6N4O2Color and Shape:SolidMolecular weight:406.28Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Formula:C23H15F4N3O2Color and Shape:SolidMolecular weight:441.38Quinacainol dihydrochloride
CAS:Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.
Formula:C21H32Cl2N2OColor and Shape:SolidMolecular weight:399.398Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Formula:C23H27ClO7Color and Shape:SolidMolecular weight:450.909ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Color and Shape:SolidMolecular weight:434.307Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Formula:C22H21FN4O4Molecular weight:424.42Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Formula:C21H20F5N3O4Purity:98.08% - 99.27%Color and Shape:SolidMolecular weight:473.39Ref: TM-T69552
1mg58.00€5mg114.00€10mg170.00€25mg266.00€300g129,112.00€50mg457.00€100mg747.00€200mg1,026.00€1mL*10mM (DMSO)118.00€PF-06761281
CAS:PF-06761281 is a partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor, oral, reducing plasma glucose concentration.Formula:C13H17NO6Color and Shape:SolidMolecular weight:283.28
