Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Found 257 products of "Sodium Channel"
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m3-Huwentoxin IV
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6Formula:C170H271N53O46S6Purity:98%Color and Shape:SolidMolecular weight:3985.69Mambalgin-2
Mambalgin-2 (Mamb-2), a venom peptide sourced from the African black mamba, acts as an inhibitor of acid-sensitive ion channels (ASICs).Formula:C272H431N85O83S10Purity:98%Color and Shape:SolidMolecular weight:6540.5BDS-II
BDS-II, a peptide toxin comprising 43 amino acids, selectively inhibits the Kv3.4 channel [1].Formula:C214H301N57O57S6Purity:98%Color and Shape:SolidMolecular weight:4776.42Hainantoxin-IV
CAS:Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues forFormula:C166H257N53O50S6Purity:98%Color and Shape:SolidMolecular weight:3987.53ATX-II
CAS:ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked toFormula:C213H323N63O61S6Purity:98%Color and Shape:SolidMolecular weight:4934.62GpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Color and Shape:Odour SolidASG-5ME
ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.Purity:98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.5 kDaZandatrigine
CAS:Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsyFormula:C22H25FN4O2S2Purity:99.98%Color and Shape:SolidMolecular weight:460.59Ref: TM-T39630
1mg111.00€2mg164.00€5mg268.00€10mg439.00€25mg707.00€50mg1,009.00€100mg1,333.00€1mL*10mM (DMSO)294.00€Hm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1Formula:C170H239N47O54S6Purity:98%Color and Shape:SolidMolecular weight:3997.39ω-Conotoxin CVIB
CAS:ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs).Formula:C102H173N41O32S7Purity:98%Color and Shape:SolidMolecular weight:2710.18Aah II
Aah II, a sodium channel modulator, is a toxin derived from the venom of the scorpion Androctonus australis [1] [2].Formula:C313H457N89O95S8Purity:98%Color and Shape:SolidMolecular weight:7243.04Indenebart
Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.Color and Shape:Odour Liquidµ-Conotoxin BuIIIC
CAS:μ-Conotoxin BuIIIC (Mu-Conotoxin BuIIIC) effectively inhibits the NaV1.4 sodium channel [1].Formula:C116H189N49O34S6Purity:98%Color and Shape:SolidMolecular weight:3006.44Ceratotoxin-2
CAS:Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel inhibitor, demonstrating half maximal inhibitory concentrations (IC50) of 8 nM for Na v 1.2/β 1 and 88Formula:C177H260N52O49S6Purity:98%Color and Shape:SolidMolecular weight:4092.67μ-Conotoxin SxIIIC
μ-Conotoxin SxIIIC, an irreversible NaV channel inhibitor, is derived from Conus striolatus and is useful in researching neurological disorders, includingFormula:C90H142N42O27S6Purity:98%Color and Shape:SolidMolecular weight:2436.751-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Formula:C6H8N2OPurity:99.92%Color and Shape:SolidMolecular weight:124.14Jingzhaotoxin XI
Jingzhaotoxin XI (JZTX-XI) is a potent inhibitor of sodium conductance, exhibiting an IC50 value of 124 nM, and notably retards the rapid inactivation of Na_v1.Formula:C158H234N44O47S7Purity:98%Color and Shape:SolidMolecular weight:3726.27µ-Conotoxin BuIIIB
CAS:μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC), is derived from Cone snail venom andFormula:C106H172N46O30S6Purity:98%Color and Shape:SolidMolecular weight:2763.18Phlotoxin-1
Phlotoxin-1 (PhlTx1), a 34-amino acid peptide featuring three disulfide bridges, is derived from the Phlogiellus genus spider and acts as an antinociceptiveFormula:C183H254N46O48S6Purity:98%Color and Shape:SolidMolecular weight:4058.64Phlo1a
Phlo1a (μ-TrTx-Phlo1a), a 35-amino acid peptide toxin, demonstrates a weak inhibitory effect on Nav1.2 and Nav1.5 channels [1].Formula:C178H262N52O49S6Purity:98%Color and Shape:SolidMolecular weight:4106.69Phlo1b
Phlo1b (μ-TrTx-Phlo1b), a 35-amino acid peptide toxin, selectively inhibits Nav1.7 channels with minimal inhibition of Nav1.2 and Nav1.5 [1].Formula:C181H260N52O49S6Purity:98%Color and Shape:SolidMolecular weight:4140.71APETx2
CAS:ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.Formula:C196H280N54O61S6Purity:98%Color and Shape:SolidMolecular weight:4561.06Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Formula:C272H429N85O84S10Purity:98%Color and Shape:SolidMolecular weight:6554.51Benzonatate (PEGn)
CAS:Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.Formula:(C2H4O)nC12H17NO2Color and Shape:SolidPterinotoxin-1
Pterinotoxin-1 is a peptide toxin that functions as an inhibitor of sodium channels [1].Formula:C163H251N49O53S7Purity:98%Color and Shape:SolidMolecular weight:3969.49ProTx-III
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodiumFormula:C162H246N52O43S6Purity:98%Color and Shape:SolidMolecular weight:3802.4Scorpion toxin Tf2
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-Formula:C309H438N80O87S9Purity:98%Color and Shape:SolidMolecular weight:6953.86ProTx II
CAS:Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.
Formula:C168H250N46O41S8Purity:98%Color and Shape:SolidMolecular weight:3826.59µ-Conotoxin-CnIIIC
CAS:μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 channel blocker, exhibiting analgesic,Formula:C92H139N35O28S6Purity:98%Color and Shape:SolidMolecular weight:2375.7Solpecainol
CAS:solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Formula:C18H23NO3Purity:99.71%Color and Shape:SoildMolecular weight:301.38δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Formula:C326H482N92O96S8Purity:98%Color and Shape:SolidMolecular weight:7482.39NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formula:C23H20ClN3O3Color and Shape:SolidMolecular weight:421.11932Crotamine
Crotamine, a 42 amino acid toxin featuring three disulfide bridges, functions as a Na+ channel modulator with analgesic properties.Formula:C214H326N64O54S7Purity:98%Color and Shape:SolidMolecular weight:4883.735-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurity:97.87%Color and Shape:SolidMolecular weight:200.36Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Color and Shape:Odour SolidJingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.08Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Formula:C174H278N52O51S6Purity:98%Color and Shape:SolidMolecular weight:4106.79Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.67δ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].Formula:C304H458N90O93S8Purity:98%Color and Shape:SolidMolecular weight:7117.96Trapencaine
CAS:Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.Formula:C22H34N2O3Purity:97.68%Color and Shape:SolidMolecular weight:374.52OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Formula:C308H466N90O95S8Purity:98%Color and Shape:SolidMolecular weight:7206.1Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formula:C17H16N6OPurity:99.74%Color and Shape:SolidMolecular weight:320.35δ-Theraphotoxin-Hm1a toxin
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [Formula:C170H240N48O53S6Purity:98%Color and Shape:SolidMolecular weight:3996.4Jingzhaotoxin-V
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodiumFormula:C157H243N47O37S7Purity:98%Color and Shape:SolidMolecular weight:3605.36Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Formula:C176H269N51O48S6Purity:98%Color and Shape:SolidMolecular weight:4059.74Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFormula:C154H228N44O45S6Purity:98%Color and Shape:SolidMolecular weight:3608.12Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).Formula:C276H414N76O84S8Purity:98%Color and Shape:SolidMolecular weight:6397.22Tap1a
Theraphotoxin-Tap1a (Tap1a) is a spider venom-derived peptide that acts as an inhibitor of sodium channels, displaying IC50 values of 80 nM for Na v 1.7 and 301Formula:C174H258N52O55S7Purity:98%Color and Shape:SolidMolecular weight:4182.68SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Formula:C19H13ClN2O2SPurity:99.86%Color and Shape:SolidMolecular weight:368.84Jingzhaotoxin-II
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodiumFormula:C154H219N39O45S7Purity:98%Color and Shape:SolidMolecular weight:3561.08
