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OAT

OAT

Organic anion transporters are a family of membrane proteins that mediate the uptake and excretion of various endogenous and exogenous organic anions, including drugs, toxins, and metabolic byproducts. OATs are primarily expressed in the kidneys and liver, where they play a crucial role in detoxification and drug clearance. Dysregulation of OAT function can lead to drug toxicity and kidney disorders. At CymitQuimica, we provide a variety of OAT modulators to support your research in pharmacology, toxicology, and renal function.

Found 33 products for "OAT".

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  • Puliginurad
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    Puliginurad

    CAS:
    Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.
    Formula:C19H16N2O2S
    Purity:99.50% - 99.96%
    Color and Shape:White Solid
    Molecular weight:336.41

    Ref: TM-T61048

  • URAT1&XO inhibitor 2
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    URAT1&XO inhibitor 2

    CAS:
    Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for
    Formula:C14H12BrNO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:322.15

    Ref: TM-T79177

  • Lingdolinurad
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    Lingdolinurad

    CAS:
    Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.
    Formula:C17H12BrN3O2
    Purity:96.05%
    Color and Shape:Solid
    Molecular weight:370.2

    Ref: TM-T79854

  • URAT1 inhibitor 1
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    URAT1 inhibitor 1

    CAS:
    URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.
    Formula:C19H15Br2N5O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:569.293

    Ref: TM-T13259

  • URAT1 inhibitor 6
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    URAT1 inhibitor 6

    CAS:
    URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,
    Formula:C9H7BrN3NaO2S2
    Color and Shape:Solid
    Molecular weight:356.2

    Ref: TM-T79176

  • URAT1 inhibitor 8
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    URAT1 inhibitor 8

    CAS:
    URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.
    Formula:C19H13ClFN3O4S
    Color and Shape:Solid
    Molecular weight:433.84

    Ref: TM-T78195

  • URAT1-IN-14
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    URAT1-IN-14

    CAS:
    URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.
    Formula:C19H19NO3S
    Color and Shape:Solid
    Molecular weight:341.42

    Ref: TM-T212313

  • URAT1 inhibitor 13
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    URAT1 inhibitor 13

    CAS:
    URAT1 inhibitor13 (compound 22k) is a potent inhibitor of URAT1, useful for research related to gout.
    Formula:C18H14Cl2N2O2
    Color and Shape:Solid
    Molecular weight:361.22

    Ref: TM-T207176

  • TRPV1 antagonist 10
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    TRPV1 antagonist 10

    CAS:
    TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.
    Formula:C16H14N2O5
    Color and Shape:Solid
    Molecular weight:314.293

    Ref: TM-T207037

  • KPH2f
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    KPH2f

    CAS:
    KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.
    Formula:C24H16N3NaO2S
    Color and Shape:Solid
    Molecular weight:433.46

    Ref: TM-T62432

  • hURAT1 inhibitor 2
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    hURAT1 inhibitor 2

    CAS:
    hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.
    Formula:C17H11Br2FO3
    Color and Shape:Solid
    Molecular weight:442.074

    Ref: TM-T206558

  • CymitQuimica logo
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    URAT1 inhibitor 3

    URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.
    Formula:C14H8Cl2N2O2
    Color and Shape:Solid
    Molecular weight:307.13

    Ref: TM-T60724

  • CymitQuimica logo
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    URAT1 inhibitor 2

    URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.
    Formula:C21H18BrN3O2S
    Color and Shape:Solid
    Molecular weight:456.36

    Ref: TM-T62825