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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • Z-HA155
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    Z-HA155

    CAS:
    <p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>
    Formula:C24H19BFNO5S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:463.29

    Ref: TM-T11533

  • ML-030
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    ML-030

    CAS:
    <p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>
    Formula:C20H20N4O4S
    Purity:97.93%
    Color and Shape:Solid
    Molecular weight:412.46

    Ref: TM-T5496

  • GSK256066
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    GSK256066

    CAS:
    <p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, &gt;380, 000-fold selectivity versus PDE1/2/3/5/6 and &gt;2500-fold</p>
    Formula:C27H26N4O5S
    Purity:99.60% - 99.66%
    Color and Shape:Solid
    Molecular weight:518.58

    Ref: TM-T6054

  • MBCQ
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    MBCQ

    CAS:
    <p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>
    Formula:C16H12ClN3O2
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:313.74

    Ref: TM-T21965

  • ICI 63197
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    ICI 63197

    CAS:
    <p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>
    Formula:C9H13N5O
    Purity:99.70%
    Color and Shape:White Solid
    Molecular weight:207.23

    Ref: TM-T22851

  • Amino Tadalafil
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    Amino Tadalafil

    CAS:
    <p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>
    Formula:C21H18N4O4
    Purity:99.85%
    Color and Shape:White Powder
    Molecular weight:390.39

    Ref: TM-T7542

  • PDE10-IN-1
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    PDE10-IN-1

    CAS:
    <p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>
    Formula:C21H19N7
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:369.42

    Ref: TM-T5411

  • Cilomilast
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    Cilomilast

    CAS:
    <p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>
    Formula:C20H25NO4
    Purity:97.37% - 99.52%
    Color and Shape:White Solid
    Molecular weight:343.42

    Ref: TM-T6445

  • K-Ras-PDEδ-IN-1
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    K-Ras-PDEδ-IN-1

    CAS:
    <p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>
    Formula:C25H26FN5O2
    Purity:99.48%
    Color and Shape:Solid
    Molecular weight:447.5

    Ref: TM-T8659

  • THPP-1
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    THPP-1

    CAS:
    <p>THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).</p>
    Formula:C23H21ClN6O3
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:464.9

    Ref: TM-T8506

  • Piclamilast
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    Piclamilast

    CAS:
    <p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>
    Formula:C18H18Cl2N2O3
    Purity:98.28% - 99.57%
    Color and Shape:Solid
    Molecular weight:381.25

    Ref: TM-T23154

  • Irsogladine
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    Irsogladine

    CAS:
    <p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>
    Formula:C9H7Cl2N5
    Purity:99.74% - 99.91%
    Color and Shape:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly Bitter
    Molecular weight:256.09

    Ref: TM-T6548

  • Homo Sildenafil
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    Homo Sildenafil

    CAS:
    <p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>
    Formula:C23H32N6O4S
    Purity:99.88%
    Color and Shape:White Solid
    Molecular weight:488.6

    Ref: TM-T8919

  • Balipodect
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    Balipodect

    CAS:
    <p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is &gt;15000-fold over other PDEs.</p>
    Formula:C23H17FN6O2
    Purity:98% - 99.79%
    Color and Shape:Solid
    Molecular weight:428.42

    Ref: TM-T1745

  • BRL-50481
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    BRL-50481

    CAS:
    <p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>
    Formula:C9H12N2O4S
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:244.27

    Ref: TM-T5106

  • Lodenafil
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    Lodenafil

    CAS:
    <p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>
    Formula:C23H32N6O5S
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:504.6

    Ref: TM-T7346

  • BW-A 78U
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    BW-A 78U

    CAS:
    <p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>
    Formula:C13H12FN5
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:257.27

    Ref: TM-T5101

  • RS-25344 hydrochloride
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    RS-25344 hydrochloride

    CAS:
    <p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>
    Formula:C19H14ClN5O4
    Purity:99.25%
    Color and Shape:Solid
    Molecular weight:411.8

    Ref: TM-T23256

  • [11C]MP 10
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    [11C]MP 10

    CAS:
    <p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>
    Formula:C25H20N4O
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:391.45

    Ref: TM-T6042

  • Roflumilast N-oxide
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    Roflumilast N-oxide

    CAS:
    <p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>
    Formula:C17H14Cl2F2N2O4
    Purity:98.19% - 99.69%
    Color and Shape:Solid
    Molecular weight:419.21

    Ref: TM-T4462