PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 169 products of "PDE"
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BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Formula:C28H31F6NO3Purity:98.4%Color and Shape:SolidMolecular weight:543.54Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Formula:C23H24F2N2O5Purity:99.47% - 99.64%Color and Shape:SolidMolecular weight:446.44PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Formula:C14H15F3N8OSPurity:99.02%Color and Shape:SolidMolecular weight:400.38Ref: TM-T12422
1mg130.00€5mg222.00€10mg334.00€25mg578.00€50mg838.00€100mg1,251.00€1mL*10mM (DMSO)195.00€GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Formula:C21H25N7O2SPurity:99.90% - 99.97%Color and Shape:SolidMolecular weight:439.53CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Formula:C23H19N5O2Color and Shape:SolidMolecular weight:397.43Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Formula:C14H16N6OPurity:99.62% - 99.87%Color and Shape:SolidMolecular weight:284.32Ref: TM-T12913
2mg40.00€5mg63.00€10mg88.00€25mg185.00€50mg296.00€100mg457.00€200mg647.00€1mL*10mM (DMSO)67.00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Formula:C16H14N4OPurity:99.52% - >99.99%Color and Shape:SolidMolecular weight:278.31PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurity:98%Color and Shape:SolidMolecular weight:491.52Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurity:98.82% - 99.50%Color and Shape:SolidMolecular weight:519.62Ref: TM-T15381
1mg185.00€5mg415.00€10mg613.00€25mg938.00€50mg1,311.00€100mg1,768.00€1mL*10mM (DMSO)520.00€Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purity:98%Color and Shape:SolidMolecular weight:443.46Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C30H29N9O2Purity:98%Color and Shape:SolidMolecular weight:547.61MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurity:99.38% - 99.67%Color and Shape:SolidMolecular weight:382.48TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurity:99.21%Color and Shape:SolidMolecular weight:460.45Ref: TM-T13189
1mg87.00€2mg114.00€5mg177.00€10mg264.00€25mg460.00€50mg668.00€100mg945.00€500mg1,783.00€1mL*10mM (DMSO)178.00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary
Formula:C24H35N5O3Purity:>99.99%Color and Shape:SolidMolecular weight:441.57Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Formula:C21H15Cl2F2N3O2SPurity:99.9%Color and Shape:SolidMolecular weight:482.33Ref: TM-T63190
1mg73.00€5mg161.00€10mg235.00€25mg420.00€50mg627.00€100mg880.00€200mg1,161.00€1mL*10mM (DMSO)166.00€AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Formula:C25H23N5O3Purity:99.87%Color and Shape:SolidMolecular weight:441.48Ref: TM-T14217
1mg34.00€2mg44.00€5mg70.00€10mg100.00€25mgTo inquire50mgTo inquire1mL*10mM (DMSO)78.00€PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Formula:C18H20ClN5OPurity:98.75%Color and Shape:SolidMolecular weight:357.84Ref: TM-T28352
1mg37.00€5mg70.00€10mg88.00€25mg144.00€50mg207.00€100mg309.00€200mg440.00€1mL*10mM (DMSO)79.00€Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Formula:C23H32N4O4Purity:99.87%Color and Shape:SolidMolecular weight:428.52Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Formula:C24H29ClN6OSPurity:99.81%Color and Shape:SolidMolecular weight:485.05Ref: TM-T9773
1mg58.00€5mg130.00€10mg187.00€25mg304.00€50mg393.00€100mg552.00€200mg725.00€1mL*10mM (DMSO)148.00€NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47
