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Aminopeptidase

Aminopeptidase

Aminopeptidases are a group of enzymes that catalyze the cleavage of amino acids from the N-terminus of peptides and proteins, playing a crucial role in protein maturation and degradation. These enzymes are involved in various physiological processes, including antigen processing, peptide hormone regulation, and cellular homeostasis. Inhibitors of aminopeptidases are of interest in the treatment of diseases such as cancer, inflammation, and infectious diseases. At CymitQuimica, we provide a variety of aminopeptidase inhibitors to support your research in proteomics, drug development, and disease treatment.

Found 67 products of "Aminopeptidase"

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  • RB 101
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    RB 101

    CAS:
    <p>RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.</p>
    Formula:C31H38N2O3S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:582.84

    Ref: TM-T26048

  • MetAP2-IN-1
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    MetAP2-IN-1

    CAS:
    <p>MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].</p>
    Formula:C8H6BrN3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:224.06

    Ref: TM-T78129

  • Arphamenine A
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    Arphamenine A

    CAS:
    <p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>
    Formula:C16H24N4O3
    Color and Shape:Solid
    Molecular weight:320.387

    Ref: TM-TN10713

  • A-800141
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    A-800141

    CAS:
    <p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>
    Formula:C24H30N2O4S
    Color and Shape:Solid
    Molecular weight:442.571

    Ref: TM-T204983

  • EC33
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    EC33

    CAS:
    <p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>
    Formula:C4H11NO3S2
    Color and Shape:Solid
    Molecular weight:185.27

    Ref: TM-T86337

  • LTA4H-IN-3
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    LTA4H-IN-3

    CAS:
    <p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>
    Formula:C17H15ClN4O3
    Color and Shape:Solid
    Molecular weight:358.78

    Ref: TM-T86828

  • LTA4H-IN-2
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    LTA4H-IN-2

    CAS:
    <p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>
    Formula:C20H19FN6O2
    Color and Shape:Solid
    Molecular weight:394.4

    Ref: TM-T86827

  • Bestatin methyl ester
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    Bestatin methyl ester

    CAS:
    <p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>
    Formula:C17H26N2O4
    Color and Shape:Solid
    Molecular weight:322.4

    Ref: TM-T88754

  • Ketomethylenebestatin
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    Ketomethylenebestatin

    CAS:
    <p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>
    Formula:C17H25NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:307.38

    Ref: TM-T25573

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    SDX-7539

    CAS:
    <p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>
    Formula:C23H38N2O5
    Molecular weight:422.56

    Ref: TM-T209478

  • PPI-2458
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    PPI-2458

    CAS:
    <p>PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.</p>
    Formula:C22H36N2O6
    Color and Shape:Solid
    Molecular weight:424.53

    Ref: TM-T69258

  • QGC583
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    QGC583

    CAS:
    <p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>
    Formula:C13H20NO5P
    Color and Shape:Solid
    Molecular weight:301.28

    Ref: TM-T200621

  • 4-MDM
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    4-MDM

    CAS:
    <p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>
    Formula:C14H14O
    Color and Shape:Solid
    Molecular weight:198.26

    Ref: TM-T204132

  • ERAP1 modulator-2
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    ERAP1 modulator-2

    CAS:
    <p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>
    Formula:C22H25F3N2O4S
    Color and Shape:Solid
    Molecular weight:470.505

    Ref: TM-T204335

  • Beloranib
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    Beloranib

    CAS:
    <p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>
    Formula:C29H41NO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:499.64

    Ref: TM-T19871

  • TNP-470
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    TNP-470

    CAS:
    <p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>
    Formula:C19H28ClNO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.88

    Ref: TM-T17110

  • Actinonin
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    Actinonin

    CAS:
    <p>Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].</p>
    Formula:C19H35N3O5
    Color and Shape:Solid
    Molecular weight:385.5

    Ref: TM-T14121

    1mg
    Discontinued
    Discontinued product