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UGT

UGT

UDP-Glucuronosyltransferases (UGTs) are enzymes involved in the detoxification of xenobiotics and endogenous compounds by catalyzing the glucuronidation process, which makes these substances more water-soluble and easier to excrete. UGT inhibitors are important in the study of drug metabolism, as they can alter the pharmacokinetics of therapeutic agents and influence drug efficacy and toxicity. These inhibitors are also used to investigate the role of UGTs in various diseases, including cancer and liver disorders. At CymitQuimica, we offer UGT inhibitors to support your research in toxicology, pharmacokinetics, and drug development.

Found 4 products of "UGT"

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  • Cremophor EL

    CAS:
    <p>Cremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.</p>
    Formula:C4H7Cl2NO2
    Color and Shape:Solid
    Molecular weight:172.01
  • α-Angelica lactone

    CAS:
    <p>α-Angelica lactone is a vinyl nucleophilic reagent and a naturally occurring anticancer agent. α-Angelica lactone has cardiotonic activity.</p>
    Formula:C5H6O2
    Purity:95%
    Color and Shape:Liquid
    Molecular weight:98.1
  • UK-157147

    CAS:
    <p>UK-157147 is a substrate for UGT1A1(Km: 105 μM).</p>
    Formula:C23H24N2O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:472.51
  • UGT1A1-IN-1

    CAS:
    <p>UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].</p>
    Formula:C22H19NO3
    Color and Shape:Solid
    Molecular weight:345.39