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HIF/HIF Prolyl-Hydroxylase

HIF/HIF Prolyl-Hydroxylase

Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.

Found 142 products of "HIF/HIF Prolyl-Hydroxylase"

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  • HIF-PHD-IN-2
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    HIF-PHD-IN-2

    CAS:
    <p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>
    Formula:C17H15N5O3S
    Color and Shape:Solid
    Molecular weight:369.4

    Ref: TM-T61458

  • CymitQuimica logo
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    Angiogenesis agent 1

    CAS:
    <p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>
    Formula:C20H24O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:376.4

    Ref: TM-T74217

  • BNS
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    BNS

    CAS:
    <p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>
    Formula:C18H16N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.46

    Ref: TM-T26880

  • M1002
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    M1002

    CAS:
    <p>M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.</p>
    Formula:C15H8F6N2O2S
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:394.29

    Ref: TM-T61822

  • 103D5R
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    103D5R

    CAS:
    <p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>
    Formula:C20H21N3O2
    Color and Shape:Solid
    Molecular weight:335.4

    Ref: TM-T68718

  • HIF-IN-33
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    HIF-IN-33

    CAS:
    <p>HIF-IN-33 is an inhibitor of HIF pathway.</p>
    Formula:C21H17F3N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.38

    Ref: TM-T25502

  • Langkamide
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    Langkamide

    CAS:
    <p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>
    Formula:C16H17NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:303.31

    Ref: TM-T27796

  • ENMD-1198
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    ENMD-1198

    CAS:
    <p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>
    Formula:C20H25NO2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:311.42

    Ref: TM-T15234

  • HIF-1/2α-IN-2
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    HIF-1/2α-IN-2

    CAS:
    <p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>
    Formula:C16H11FN4O2S
    Color and Shape:Solid
    Molecular weight:342.35

    Ref: TM-T61102

  • THS-044
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    THS-044

    CAS:
    <p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>
    Formula:C11H12F3N3O3
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:291.23

    Ref: TM-T13925

  • KCN1
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    KCN1

    CAS:
    <p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>
    Formula:C26H27NO5S
    Color and Shape:Solid
    Molecular weight:465.56

    Ref: TM-T68324

  • TM6089
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    TM6089

    CAS:
    <p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>
    Formula:C13H14N4O3S
    Purity:99.70%
    Color and Shape:Solid
    Molecular weight:306.34

    Ref: TM-T17105

  • HIF-1α inhibitor-1
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    HIF-1α inhibitor-1

    CAS:
    <p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>
    Formula:C15H11N3O4
    Color and Shape:Solid
    Molecular weight:297.27

    Ref: TM-T71661

  • KRH102140
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    KRH102140

    CAS:
    <p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>
    Formula:C25H24FNO
    Purity:98.31% - 99.61%
    Color and Shape:Solid
    Molecular weight:373.46

    Ref: TM-T68511

  • HIF-2α-IN-3
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    HIF-2α-IN-3

    CAS:
    <p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>
    Formula:C12H6ClN5O5
    Purity:98.11%
    Color and Shape:Solid
    Molecular weight:335.66

    Ref: TM-T11562

  • TC-S 7009
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    TC-S 7009

    CAS:
    <p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization &amp; gene expression.</p>
    Formula:C12H6ClFN4O3
    Purity:99.46% - 99.71%
    Color and Shape:Solid
    Molecular weight:308.65

    Ref: TM-T17009

  • HIF-2α-IN-13
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    HIF-2α-IN-13

    CAS:
    <p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>
    Formula:C15H14ClF4NO2
    Color and Shape:Solid
    Molecular weight:351.72

    Ref: TM-T88052

  • PHD-IN-2
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    PHD-IN-2

    CAS:
    <p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>
    Formula:C26H27N7O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:501.54

    Ref: TM-T79798

  • Prolyl Hydroxylase inhibitor 1
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    Prolyl Hydroxylase inhibitor 1

    CAS:
    <p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>
    Formula:C19H18ClN5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.83

    Ref: TM-T12547

  • PHD2-IN-1
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    PHD2-IN-1

    CAS:
    <p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>
    Formula:C21H23ClN4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.88

    Ref: TM-T79241