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ROR

ROR

Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.

Found 42 products of "ROR"

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  • SR0987
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    SR0987

    CAS:
    <p>SR0987 is a RORγt agonist,</p>
    Formula:C16H10ClF6NO2
    Purity:99.43%
    Color and Shape:Solid
    Molecular weight:397.7

    Ref: TM-T4670

  • Nobiletin
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    Nobiletin

    CAS:
    <p>Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.</p>
    Formula:C21H22O8
    Purity:98.65% - 99.76%
    Color and Shape:Solid
    Molecular weight:402.39

    Ref: TM-T2834

  • MRL-871
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    MRL-871

    CAS:
    <p>MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.</p>
    Formula:C22H12ClF3N2O3
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:444.79

    Ref: TM-T62622

  • RORγt Inverse agonist 8
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    RORγt Inverse agonist 8

    CAS:
    <p>RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).</p>
    Formula:C26H33N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:475.59

    Ref: TM-T12754

  • Methyl-3β-hydroxycholenate
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    Methyl-3β-hydroxycholenate

    CAS:
    <p>Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.</p>
    Formula:C25H40O3
    Purity:98.78%
    Color and Shape:Solid
    Molecular weight:388.58

    Ref: TM-T11923

  • TF-S14
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    TF-S14

    CAS:
    <p>TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.</p>
    Formula:C22H27N3O2S
    Color and Shape:Solid
    Molecular weight:397.53

    Ref: TM-T88018

  • XY101
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    XY101

    CAS:
    <p>XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).</p>
    Formula:C25H20F7NO4S
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:563.48

    Ref: TM-T13362

  • AZD-0284
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    AZD-0284

    CAS:
    <p>AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].</p>
    Formula:C21H18F6N2O5S
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:524.43

    Ref: TM-T14369

  • ML 209
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    ML 209

    CAS:
    <p>ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription</p>
    Formula:C25H31NO6
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:441.52

    Ref: TM-T37587

  • SR2211
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    SR2211

    CAS:
    <p>SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).</p>
    Formula:C26H24F7N3O
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:527.48

    Ref: TM-T16929

  • 3-Oxo-5β-cholanoic acid
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    3-Oxo-5β-cholanoic acid

    CAS:
    <p>3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly</p>
    Formula:C24H38O3
    Purity:98.01% - 99.86%
    Color and Shape:Solid
    Molecular weight:374.56

    Ref: TM-T13502

  • RORγt Inverse agonist 6
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    RORγt Inverse agonist 6

    CAS:
    <p>RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.</p>
    Formula:C28H29ClN6O5
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:565.02

    Ref: TM-T12753

  • FM26
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    FM26

    CAS:
    <p>FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.</p>
    Formula:C22H15ClF3N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.82

    Ref: TM-T11308

  • TMP780
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    TMP780

    CAS:
    <p>TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.</p>
    Formula:C31H30N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:494.58

    Ref: TM-T13172

  • CymitQuimica logo
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    RORγt inverse agonist 14

    CAS:
    <p>RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.</p>
    Formula:C26H26F8N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:678.61

    Ref: TM-T72252

  • RORγt inverse agonist 34
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    RORγt inverse agonist 34

    CAS:
    <p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>
    Formula:C31H37N3O3S
    Color and Shape:Solid
    Molecular weight:531.709

    Ref: TM-T204288

  • RORγt inhibitor 4
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    RORγt inhibitor 4

    CAS:
    <p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>
    Formula:C22H16Cl2F3NO4S
    Color and Shape:Solid
    Molecular weight:518.333

    Ref: TM-T205045

  • CymitQuimica logo
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    ROR1-IN-1

    CAS:
    <p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>
    Formula:C33H27N5O3
    Molecular weight:541.60

    Ref: TM-T210170

  • TAK-828F
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    TAK-828F

    CAS:
    <p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>
    Formula:C28H32FN3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.57

    Ref: TM-T13067

  • RORγt inverse agonist 32
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    RORγt inverse agonist 32

    CAS:
    <p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>
    Formula:C24H28F3NO5S
    Color and Shape:Solid
    Molecular weight:499.54

    Ref: TM-T200887