ROR
Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.
Found 47 products for "ROR".
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T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formula:C17H12F9NO3SPurity:98% - 99.64%Color and Shape:SolidMolecular weight:481.33Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Formula:C24H20Cl3F3N2O3Purity:99.20%Color and Shape:White SolidMolecular weight:547.78Ref: TM-T9635
1mg81.00€5mg167.00€1mL*10mM (DMSO)197.00€10mg259.00€25mg470.00€50mg703.00€100mg1,044.00€200mg1,404.00€SR0987
CAS:SR0987 is a RORγt agonist,Formula:C16H10ClF6NO2Purity:99.43%Color and Shape:SolidMolecular weight:397.7Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Formula:C21H22O8Purity:98.65% - 99.76%Color and Shape:Yellow SolidMolecular weight:402.39Ref: TM-T2834
5mg54.00€1mL*10mM (DMSO)56.00€10mg84.00€25mg117.00€50mg159.00€100mg251.00€200mg371.00€500mg620.00€MRL-871
CAS:MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Formula:C22H12ClF3N2O3Purity:99.66%Color and Shape:SolidMolecular weight:444.79Ref: TM-T62622
1mg90.00€5mg215.00€1mL*10mM (DMSO)236.00€10mg356.00€25mg715.00€50mg1,153.00€100mg1,783.00€200mg2,412.00€GNE-0946
CAS:GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. autoimmune disease research.Formula:C22H12ClF3N2O4Purity:98.11%Color and Shape:SolidMolecular weight:460.79XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Formula:C25H20F7NO4SPurity:99.83%Color and Shape:SolidMolecular weight:563.48Ref: TM-T13362
1mg82.00€5mg161.00€1mL*10mM (DMSO)193.00€10mg269.00€25mg427.00€50mg610.00€100mg820.00€500mg1,603.00€Methyl-3β-hydroxycholenate
CAS:Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.Formula:C25H40O3Purity:98.78%Color and Shape:SolidMolecular weight:388.58RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Formula:C26H33N7O2Purity:98%Color and Shape:SolidMolecular weight:475.59TF-S14
CAS:TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.Formula:C22H27N3O2SColor and Shape:SolidMolecular weight:397.53ROR1-IN-2
ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.Formula:C30H27N3O4Color and Shape:SolidMolecular weight:493.20016SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Formula:C26H24F7N3OPurity:98.75%Color and Shape:White SolidMolecular weight:527.48Ref: TM-T16929
1mg49.00€5mg90.00€1mL*10mM (DMSO)114.00€10mg170.00€25mg260.00€50mg356.00€100mg505.00€500mg1,071.00€ML 209
CAS:ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcriptionFormula:C25H31NO6Purity:99.87%Color and Shape:SolidMolecular weight:441.52AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Formula:C21H18F6N2O5SPurity:99.82%Color and Shape:SolidMolecular weight:524.43RORγt Inverse agonist 6
CAS:RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.Formula:C28H29ClN6O5Purity:99.52%Color and Shape:SolidMolecular weight:565.02Ref: TM-T12753
1mg58.00€5mg133.00€1mL*10mM (DMSO)165.00€10mg190.00€25mg306.00€50mg414.00€100mg532.00€200mg705.00€TMP780
CAS:TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Formula:C31H30N2O4Purity:98%Color and Shape:SolidMolecular weight:494.58RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Formula:C26H26F8N2O6S2Purity:98%Color and Shape:SolidMolecular weight:678.613-Oxo-5β-cholanoic acid
CAS:3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFormula:C24H38O3Purity:98.01% - 99.86%Color and Shape:White SolidMolecular weight:374.56FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Formula:C22H15ClF3N3O3Purity:98%Color and Shape:SolidMolecular weight:461.82RORγt inverse agonist 34
CAS:RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.Formula:C31H37N3O3SColor and Shape:SolidMolecular weight:531.709
