ROR
Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.
Found 48 products for "ROR".
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RORγt inverse agonist 33
RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.Formula:C27H37NO5SColor and Shape:SolidMolecular weight:487.651XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Formula:C23H19F5N2O4S2Color and Shape:SolidMolecular weight:546.07064Antitumor agent-127
Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that demonstrates nanomolar binding affinity to ROR1 and shows relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.Formula:C86H107N15O18SMolecular weight:1669.76392RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Color and Shape:Odour SolidTMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Formula:C31H30N2O4Purity:99.68%Color and Shape:SolidMolecular weight:494.58Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Formula:C26H28N8O3SPurity:99.32%Color and Shape:SolidMolecular weight:532.62ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Formula:C23H30BrN7Color and Shape:SolidMolecular weight:484.44RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Formula:C35H60N2O2Purity:98%Color and Shape:SolidMolecular weight:540.86RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Formula:C23H15Cl2F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:555.36TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Formula:C29H30N2O3Purity:99%Color and Shape:SolidMolecular weight:454.56XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Formula:C23H15F7N2O4Purity:99.95% - 99.96%Color and Shape:SolidMolecular weight:516.37Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Formula:C24H20Cl3F3N2O3Purity:99.20%Color and Shape:White SolidMolecular weight:547.78Ref: TM-T9635
1mg81.00€5mg167.00€1mL*10mM (DMSO)197.00€10mg259.00€25mg470.00€50mg703.00€100mg1,044.00€200mg1,404.00€SR0987
CAS:SR0987 is a RORγt agonist,Formula:C16H10ClF6NO2Purity:99.43%Color and Shape:SolidMolecular weight:397.7SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Formula:C15H13F6N3O4S2Purity:98.93%Color and Shape:SolidMolecular weight:477.4Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Formula:C27H23F6NO6SPurity:99.92%Color and Shape:SolidMolecular weight:603.53Ref: TM-TQ0007
1mg66.00€5mg130.00€1mL*10mM (DMSO)167.00€10mg178.00€25mg313.00€50mg447.00€100mg620.00€SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Formula:C13H9F6NO3S2Purity:99.77%Color and Shape:SolidMolecular weight:405.34Ref: TM-T5160
1mg34.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg119.00€25mg233.00€50mg371.00€100mg595.00€200mg833.00€SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Formula:C17H10F9NO2Purity:99.58%Color and Shape:SolidMolecular weight:431.25Ref: TM-T4594
1mg39.00€2mg52.00€5mg85.00€1mL*10mM (DMSO)87.00€10mg109.00€25mg215.00€50mg349.00€100mg517.00€Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Formula:C27H40O4Purity:99.5% - 99.92%Color and Shape:SolidMolecular weight:428.60S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Formula:C26H25F3N2O4SPurity:99.24% - 99.31%Color and Shape:White SolidMolecular weight:518.55Ref: TM-T16832
1mg54.00€5mg118.00€1mL*10mM (DMSO)135.00€10mg178.00€25mg318.00€50mg445.00€100mg627.00€500mg1,251.00€RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Formula:C23H17Cl2F3N2O4Purity:99.04%Color and Shape:White SolidMolecular weight:513.29Ref: TM-T9623
1mg50.00€5mg110.00€1mL*10mM (DMSO)124.00€10mg170.00€25mg295.00€50mg420.00€100mg572.00€200mg772.00€
