Dehydrogenase
Dehydrogenases are enzymes involved in the oxidation-reduction reactions of metabolic pathways, playing a central role in energy production and cellular respiration. These enzymes are crucial for processes such as the citric acid cycle, glycolysis, and fatty acid oxidation. Dehydrogenase inhibitors are important tools in the study of metabolic diseases, cancer, and oxidative stress. At CymitQuimica, we provide a comprehensive selection of dehydrogenase inhibitors to support your research in metabolism, cancer biology, and biochemistry.
Found 302 products of "Dehydrogenase"
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ASP3662
CAS:ASP3662/SPI-62: Potent, selective CNS-penetrable 11β-HSD1 inhibitor; potential neuropathic pain treatment.Formula:C19H16ClF3N4O2Color and Shape:SolidMolecular weight:424.8TM-1
CAS:TM-1: PDHK inhibitor, IC50 - PDHK1: 2.97μM, PDHK2: 5.2μM, prevents PDHC phosphorylation, inhibits cancer cell growth.Formula:C26H32N2O6Color and Shape:SolidMolecular weight:468.54DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Formula:C17H13ClN2O2Purity:98%Color and Shape:SolidMolecular weight:312.75ALDH3A1-IN-2
CAS:ALDH3A1-IN-2 is a potent inhibitor targeting ALDH3A1 (IC50=1.29µM), potentially useful in cancer research.Formula:C11H14N2O3Color and Shape:SolidMolecular weight:222.2411β-HSD1-IN-10
CAS:11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitiveFormula:C16H10F3NO2Color and Shape:SolidMolecular weight:305.2511β-HSD1-IN-9
CAS:11β-HSD1-IN-9 is a potent inhibitor of 11β-HSD1, displaying IC50 values of 0.48 µM for human and 1.3 µM for murine variants, respectively.Formula:C13H9F3N2OColor and Shape:SolidMolecular weight:266.22DHODH-IN-21
CAS:DHODH-IN-21, orally active DHODH blocker with 1.1 nM IC50, shows anticancer activity, potential for AML research.Formula:C20H19ClF4N6O4Color and Shape:SolidMolecular weight:518.85BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Formula:C23H21F6N3O2Purity:98%Color and Shape:SolidMolecular weight:485.42P1788
CAS:P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].Formula:C15H17NO3Color and Shape:SolidMolecular weight:259.3ML-148
CAS:ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).Formula:C20H21N3OPurity:99.88%Color and Shape:SolidMolecular weight:319.4Ref: TM-T38163
1mg60.00€5mg165.00€10mg254.00€25mg459.00€50mg658.00€100mg935.00€200mg1,283.00€1mL*10mM (DMSO)188.00€AMG-221
CAS:AMG-221: potent 11β-HSD1 inhibitor, lowers glucose & insulin, reduces obesity in mice.Formula:C14H22N2OSPurity:98%Color and Shape:SolidMolecular weight:266.4hDHODH-IN-11
CAS:hDHODH-IN-11: potent hDHODH inhibitor, IC50 7.2 nM, low cytotoxicity, for AML research.Formula:C24H23N3O3Color and Shape:SolidMolecular weight:401.46MEDS433
CAS:MEDS433 inhibits dihydroorotate dehydrogenase (IC50 1.2 nM) and blocks replication of hCoV-OC43, hCoV-229E, SARS-CoV-2 at nanomolar levels.Formula:C20H11F4N3O2Color and Shape:SolidMolecular weight:401.31Epostane
CAS:Epostane is a 3β-hydroxysteroid dehydrogenase inhibitor that blocks the biosynthesis of progesterone and pregnenolone.Cost-effective and quality-assured.Formula:C22H31NO3Purity:>99.99%Color and Shape:SolidMolecular weight:357.4911β-HSD1-IN-6
CAS:11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs).Formula:C21H19ClN4OColor and Shape:SolidMolecular weight:378.86Nitrefazole
CAS:Nitrefazole: a 4-nitroimidazole, inhibits ALDH enzyme crucial for alcohol metabolism, has potent, durable effects.Formula:C10H8N4O4Color and Shape:SolidMolecular weight:248.19CM39
CAS:CM39 inhibits ALDH, linked to cancer stem-like cells & chemoresistance.Formula:C19H15FN4OSColor and Shape:SolidMolecular weight:366.41DHODH-IN-24
CAS:DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].Formula:C26H26N4Color and Shape:SolidMolecular weight:394.51PHGDH-IN-3
CAS:PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.Formula:C24H18FN3O4S2Purity:97.24% - 99.1%Color and Shape:SolidMolecular weight:495.55DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Formula:C28H31F3N4O6SPurity:98.19% - >99.99%Color and Shape:SolidMolecular weight:608.63Ref: TM-T11103
1mg109.00€5mg260.00€10mg409.00€25mg737.00€50mg1,198.00€100mg1,611.00€1mL*10mM (DMSO)358.00€DSM421
CAS:DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shownFormula:C14H11F5N6Purity:99.67% - 99.82%Color and Shape:SolidMolecular weight:358.27Ref: TM-T27214
1mg110.00€5mg259.00€10mg353.00€25mg533.00€50mg718.00€100mg945.00€200mg1,251.00€1mL*10mM (DMSO)301.00€PBRM
CAS:PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research.Formula:C28H34BrNO2Purity:99.56% - 99.59%Color and Shape:SolidMolecular weight:496.48G6PD activator AG1
CAS:G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.Formula:C24H30N4S2Purity:98.38% - 99.51%Color and Shape:SolidMolecular weight:438.65CPS-11
CAS:CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.Formula:C14H12N2O5Purity:99.8% - 99.98%Color and Shape:SolidMolecular weight:288.26PKUMDL-WQ-2101
CAS:PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.Formula:C14H11N3O6Purity:99.57%Color and Shape:SolidMolecular weight:317.25ALDH1A3-IN-2
CAS:ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.Formula:C13H17NOPurity:99.84%Color and Shape:SolidMolecular weight:203.28CM037
CAS:CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminateFormula:C21H25N3O3S2Purity:99.77%Color and Shape:SolidMolecular weight:431.57IGP-1
CAS:iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.Formula:C17H15N3O3Purity:99.12% - 99.15%Color and Shape:SolidMolecular weight:309.32Ref: TM-T25526
2mg34.00€5mg49.00€10mg71.00€25mg126.00€50mg192.00€100mg304.00€200mg444.00€1mL*10mM (DMSO)84.00€BMS-823778
CAS:BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.Formula:C18H18ClN3OPurity:99.39% - 99.75%Color and Shape:SolidMolecular weight:327.81Ref: TM-T71394
1mg164.00€2mg234.00€5mg389.00€10mg532.00€25mg820.00€50mg1,063.00€100mg1,350.00€200mg1,783.00€hDHODH-IN-7
CAS:hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Formula:C21H23FN4OPurity:99.87%Color and Shape:SolidMolecular weight:366.43Ref: TM-T11031
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mg2,147.00€1mL*10mM (DMSO)266.00€IDH2R140Q-IN-2
CAS:IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).Formula:C21H18F6N6OPurity:99.92%Color and Shape:SolidMolecular weight:484.4Qc1
CAS:Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.Formula:C23H16F3N3O2SPurity:99.75%Color and Shape:SolidMolecular weight:455.45HSD-016
CAS:HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.Formula:C21H21F7N2O3SPurity:99.40% - >99.99%Color and Shape:SolidMolecular weight:514.46Ref: TM-T63569
1mg84.00€5mg280.00€10mg439.00€25mg888.00€50mg1,485.00€100mg2,358.00€1mL*10mM (DMSO)310.00€GSK321
CAS:GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.Formula:C28H28FN5O3Purity:99.73%Color and Shape:SolidMolecular weight:501.55DHODH-IN-22
CAS:DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.Formula:C21H21ClF4N6O5Color and Shape:SolidMolecular weight:548.88Anticancer agent 122
CAS:Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use inFormula:C18H15ClN2O2SColor and Shape:SolidMolecular weight:358.84AKR1C3-IN-6
CAS:AKR1C3-IN-6: Strong AKR1C3 inhibitor (IC50: 0.31 μM); weak on AKR1C2 (IC50: 73.23 μM); shows antitumor effects.Formula:C18H15F3N4O3Color and Shape:SolidMolecular weight:392.3311α-Hydroxyprogesterone
CAS:11alpha-Hydroxyprogesterone, an inactive analogue of 11beta-Hydroxyprogesterone, serves as an experimental control. Meanwhile, 11beta-Hydroxyprogesterone functions as a potent inhibitor of 11β-Hydroxysteroid dehydrogenase and activates the human mineralocorticoid receptor in COS-7 cells, with an effective dose (ED)50 of 10 nM.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.468Tetrahydro-11-dehydrocorticosterone
CAS:Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].Formula:C21H32O4Color and Shape:SolidMolecular weight:348.48HSD17B13-IN-3
CAS:HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].Formula:C22H21NO6S2Color and Shape:SolidMolecular weight:459.5415-PGDH-IN-1
CAS:15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.46IDH889
CAS:IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).Formula:C23H25FN6O2Purity:≥98%Color and Shape:SolidMolecular weight:436.48YG1702
CAS:YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.Formula:C23H30N2O7SColor and Shape:SolidMolecular weight:478.56CHK-336
CAS:CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluriaFormula:C24H20F2N4O4S2Color and Shape:SolidMolecular weight:530.57hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Formula:C17H14N2O2Purity:99.97%Color and Shape:SolidMolecular weight:278.31Ref: TM-T11546
1mg34.00€5mg71.00€10mg103.00€25mg200.00€50mg290.00€100mg404.00€200mg545.00€1mL*10mM (DMSO)78.00€AZD 4017
CAS:AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).Formula:C22H33N3O3SPurity:99.61%Color and Shape:SolidMolecular weight:419.58Ref: TM-T14388
1mg70.00€5mg152.00€10mg260.00€25mg520.00€50mg750.00€100mg1,035.00€1mL*10mM (DMSO)166.00€Anticancer agent 121
CAS:Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].Formula:C19H18N2O3SColor and Shape:SolidMolecular weight:354.42MK-0736
CAS:MK-0736 is a potent and selective 11β-HSD-1 inhibitor.Formula:C23H30F3N3O2SColor and Shape:SolidMolecular weight:469.56HSD17B13-IN-2
CAS:HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1Formula:C21H23F2NO4Color and Shape:SolidMolecular weight:391.41S07-1066
CAS:S07-1066, an aldo-keto reductase 1C3 (AKR1C3) inhibitor, enhances doxorubicin (DOX) cytotoxicity by selectively inhibiting AKR1C3-mediated reduction of DOX andFormula:C16H11Cl2FO2Purity:98%Color and Shape:SolidMolecular weight:325.16
