Dehydrogenase
Dehydrogenases are enzymes involved in the oxidation-reduction reactions of metabolic pathways, playing a central role in energy production and cellular respiration. These enzymes are crucial for processes such as the citric acid cycle, glycolysis, and fatty acid oxidation. Dehydrogenase inhibitors are important tools in the study of metabolic diseases, cancer, and oxidative stress. At CymitQuimica, we provide a comprehensive selection of dehydrogenase inhibitors to support your research in metabolism, cancer biology, and biochemistry.
Found 300 products of "Dehydrogenase"
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DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formula:C15H7F4N3O3Purity:99.81%Color and Shape:SolidMolecular weight:353.23Ref: TM-T11023
1mg109.00€2mg163.00€5mg243.00€10mg355.00€25mg532.00€50mg750.00€100mg1,009.00€500mgTo inquire1mL*10mM (DMSO)250.00€MK-0736
CAS:MK-0736 is a potent and selective 11β-HSD-1 inhibitor.Formula:C23H30F3N3O2SColor and Shape:SolidMolecular weight:469.56Anticancer agent 121
CAS:Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].Formula:C19H18N2O3SColor and Shape:SolidMolecular weight:354.4215-PGDH-IN-2
CAS:15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].Formula:C16H13NO3S2Color and Shape:SolidMolecular weight:331.41BI-3231
CAS:BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.Formula:C16H14F2N4O3SPurity:98.2%Color and Shape:SolidMolecular weight:380.37Ref: TM-T73446
1mg69.00€5mg147.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€200mg982.00€1mL*10mM (DMSO)164.00€ALDH2 modulator 1
CAS:ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
Formula:C18H18ClFN2O3Purity:99.68%Color and Shape:SoildMolecular weight:364.8KB-74935
CAS:KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.Formula:C19H18ClF4N3O3SPurity:99.4%Color and Shape:SolidMolecular weight:479.88CB29
CAS:CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
Formula:C15H15N3O5SPurity:99.36%Color and Shape:SolidMolecular weight:349.36RORγt/DHODH-IN-1
CAS:RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFormula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.997-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Formula:C15H10O3Color and Shape:SolidMolecular weight:238.238BRD7539
CAS:BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Formula:C23H22FN3O2Purity:98%Color and Shape:SolidMolecular weight:391.44FXR/HSD17B13 modulator 1
CAS:FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Formula:C26H19Cl2NO4Color and Shape:SolidMolecular weight:480.339MDH1/2-IN-1
CAS:MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Formula:C25H33NO4Color and Shape:SolidMolecular weight:411.534PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.32RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 hasFormula:C24H26ClF6N3O3SColor and Shape:SolidMolecular weight:585.99BI-4916
CAS:BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Formula:C23H24Cl2N2O6SPurity:98.55%Color and Shape:SolidMolecular weight:527.42HSD17B13-IN-84
CAS:HSD17B13-IN-84 (182) serves as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), exhibiting an IC50 of less than 0.1 μM for Estradiol. It is primarily utilized in the study of NAFLD (Nonalcoholic fatty liver diseases) [1].Formula:C19H12Cl2F3N3O3SMolecular weight:490.28T-3764518
CAS:T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).Formula:C20H17F6N5O2Purity:98%Color and Shape:SolidMolecular weight:473.37GSK864
CAS:GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Formula:C30H31FN6O4Purity:97.07%Color and Shape:SolidMolecular weight:558.615-epi-PGE1
CAS:15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Formula:C20H34O5Color and Shape:SolidMolecular weight:354.48HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C24H16Cl2F3N3O4Color and Shape:SolidMolecular weight:538.3HSD17B13-IN-44
CAS:HSD17B13-IN-44 (Compound 23) functions as an inhibitor targeting hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of < 0.1 μM against estradiol. This compound is applicable in the study of liver diseases or metabolic disorders [1].Formula:C18H14FNO5S2Color and Shape:SolidMolecular weight:407.44AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Formula:C25H33N3Color and Shape:SolidMolecular weight:375.55HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Formula:C23H23FN2O4SColor and Shape:SolidMolecular weight:442.5Etamicastat
CAS:Etamicastat can be used in the research of cardiovascular diseases.Formula:C14H15F2N3OSPurity:98%Color and Shape:SolidMolecular weight:311.3511β-HSD2-IN-2
CAS:11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.Formula:C22H21NO2Purity:99.61%Color and Shape:SolidMolecular weight:331.41HSD17B13-IN-17
CAS:HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of ＜0.1 μM for estradiol and ＜1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C20H16ClFN2O3SColor and Shape:SolidMolecular weight:418.87LDHA-IN-5
CAS:LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFormula:C27H22FN7O6S3Color and Shape:SolidMolecular weight:655.7(6S)-CP-470711
CAS:(6S)-CP-470711 (Compound 8) acts as an inhibitor of sorbitol dehydrogenase (SDH) in both humans and rats, exhibiting inhibitory concentrations (IC50) of 19 nM and 27 nM, respectively. Additionally, (6S)-CP-470711 has been shown to ameliorate diabetes in rats induced by Streptozotocin.Formula:C18H26N6O2Color and Shape:SolidMolecular weight:358.44AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.Formula:C23H20N4O3Color and Shape:SolidMolecular weight:400.43AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Formula:C24H20N2O4Color and Shape:SolidMolecular weight:400.43PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Formula:C22H20N4O3SColor and Shape:SolidMolecular weight:420.48HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Formula:C23H16Cl2FN3O3Color and Shape:SolidMolecular weight:472.317β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Formula:C21H21NO3Color and Shape:SolidMolecular weight:335.4hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Formula:C21H15ClF4N2O4Color and Shape:SolidMolecular weight:470.8PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Formula:C30H31N5O2Color and Shape:SolidMolecular weight:493.6HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Formula:C23H15Cl2N5O3Color and Shape:SolidMolecular weight:480.3HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Formula:C23H14Cl2F3N3O3Color and Shape:SolidMolecular weight:508.28DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Formula:C19H20ClF3N6OColor and Shape:SolidMolecular weight:440.85PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.Formula:C24H25N5O3Color and Shape:SolidMolecular weight:431.49Deamino-NAD sodium
CAS:Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.Formula:C21H25N6NaO15P2Color and Shape:SolidMolecular weight:686.39Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Formula:C28H30N4O2Color and Shape:SolidMolecular weight:454.56Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Formula:C30H34FN3O5Color and Shape:SolidMolecular weight:535.607HSD17B13-IN-95
CAS:HSD17B13-IN-95 (1) serves as an inhibitor for 17 β-hydroxysteroid dehydrogenase (HSD17B13), exhibiting an IC50 value of <0.1 μM for estradiol. It is applicable in researching nonalcoholic fatty liver disease [1].Formula:C24H16F6N4O4Molecular weight:538.40Oxamic acid
CAS:Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.Formula:C2H3NO3Color and Shape:SolidMolecular weight:89.05CP-642931
CAS:CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.Formula:C17H25N7OPurity:99.67% - >99.99%Color and Shape:SolidMolecular weight:343.43Etamicastat hydrochloride
CAS:Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.Formula:C14H16ClF2N3OSPurity:98.54%Color and Shape:SolidMolecular weight:347.81Ref: TM-T11238L
1mg80.00€5mg173.00€10mg259.00€25mg423.00€50mg577.00€100mg827.00€1mL*10mM (DMSO)190.00€(S)-GNE-140
CAS:(S)-GNE-140 is the less active enantiomer of GNE-140.Formula:C25H23ClN2O3S2Color and Shape:SolidMolecular weight:499.05GNE-140 racemate
CAS:GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.Formula:C25H23ClN2O3S2Color and Shape:SolidMolecular weight:499.0411β-HSD1-IN-8
CAS:11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.Formula:C10H8F3NO3Color and Shape:SolidMolecular weight:247.173
