Microbiology/Virology

<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>

<p>Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.</p>

<p>NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>

<p>LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.</p>

<p>Schineolignin B is a useful organic compound for research related to life sciences and the catalog number is T126011.</p>

<p>Linearmycin A, a polyene antibiotic from Streptomyces, fights S. aureus, E. coli, S. cerevisiae, C. albicans, and A. niger with low MICs.</p>

<p>m-Chloramphenicol, an impurity, hinders bacterial protein synthesis as a potent broad-spectrum antibiotic.</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

<p>DENV ligand 2 is a ligand for the DENV E protein. It is used in the synthesis of the PROTAC degrader ZXH-8-004 and serves as the active form of DENV ligand 1.</p>

<p>PD 135390 is a HIV-1 protease inhibitors identified by rational selection. Inactivation of the protease prevents infectious virion formation.</p>

<p>TS-0022666 is a selective TUT4/7 inhibitor, antiproliferative and anti-leukaemic in vivo and in vitro, cancers with FOCAD deficiency.</p>

<p>Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.</p>

<p>Remdesivir metabolite, antiviral nucleoside analog, effective against SARS-CoV and MERS-CoV.</p>

<p>Chloroorienticin A is an antibiotic in the class of glycopeptide.</p>

<p>OP-145 is a derivative of the antimicrobial peptide LL-37, known for its antibacterial properties against multiple MRSA strains. This compound is applicable in studies on chronic suppurative otitis media.</p>

<p>Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.</p>

<p>Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.</p>

<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>

<p>Arbekacin is an aminoglycoside antibiotic.</p>

<p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>

<p>5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].</p>

<p>WAY-604663 (2,3-diphenylquinoxaline-6-sulfonamide) may have antibacterial analgesic and anti-inflammatory activities.</p>

<p>Tuberculosis inhibitor 9 (compound 3d), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against Mycobacterium tuberculosis and</p>

<p>Monocerin, from F. larvarum, combats E. coli, B. megaterium, M. violaceum, C. fusca; kills C. erythrocephala; hinders S. halepense root growth.</p>

<p>Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity [1] .</p>

<p>Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.</p>

<p>Cymoxanil is a fungicidal against plant diseases caused by fungi belonging to the Perenosporales[1].</p>

<p>Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects.</p>

<p>WAY-324208 shows antifungal properties against S. dermatitidis (skin-infecting fungi), with activity against other fungi to be explored.</p>

<p>5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.</p>

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.</p>

<p>NNRT-IN-6 (Compound 13a) is a non-nucleoside reverse transcriptase inhibitor (NNRT) used to inhibit HIV-1 reverse transcriptase (HIV-1RT), with an IC50 of 0.41 μM. It effectively suppresses both wild-type HIV-1 and mutants L100I, K103N, Y181C, Y188L, E138K, F227L/V106A, and RES056, with an EC50 range of 6.2-250 nM.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.

<p>broad spectrum antibiotic</p>

<p>LeuRS-IN-1 is a leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity that inhibits M.tb LeuRS.</p>

<p>SARS-CoV-2-IN-46 is a SARS-CoV-2 inhibitor.</p>

<p>Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>dmDNA31: a rifamycin antibiotic, inhibits bacterial RNA polymerase, strongly kills Staphylococcus aureus.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>4-(2-Aminoethyl)amino-7-chloroquinoline (N1-(7-Chloroquinolin-4-yl)ethane-1,2-diamine) has potential anthelmintic and antitumor activity for the study of</p>

<p>Spike protein mRNA for COVID-19 enables protein expression, assesses RNA delivery, translation, cell health, and is key for virus entry and vaccine targets.</p>

<p>Cefazaflur is a novel semi-synthetic cephalosporin derivative that can be used as an Antibiotic agent.</p>

<p>Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with</p>

<p>Ascochin, an isocoumarin derivative and fungal metabolite identified in Ascochyta, demonstrates antimicrobial activity. At a concentration of 0.5 mg/disc, it inhibits Bacillus megaterium (the bacterium), Mycosphaerella violaceum (the plant pathogenic fungus), and Chlorella fusca (the alga) in agar diffusion assays.</p>

<p>FR179642 is a key intermediate for making Micafungin, a drug from the echinocandin class.</p>

<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>Agent 38 from patent WO2015063714A1 (C) serves as an antibacterial for scientific study.</p>

<p>Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly</p>

<p>Amphotericin B trihydrate, a polyene antibiotic, is derived from Streptomyces nodosus fermenter cultures. It exhibits antileishmanial properties.</p>

<p>Antibacterial Agent 33 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.</p>

<p>Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting</p>

<p>ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) is a potent inhibitor of bacterial</p>

<p>Antibacterialagent 220 is a potent antibacterial compound that directly disrupts bacterial cell membranes. It is effective against both Gram-positive and Gram-negative bacteria, including resistant strains.</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>

<p>HCVcc-IN-1, a derivative of benzothiazole-2-thiophene S-glycoside, exhibits low toxicity and antiviral properties [1].</p>

<p>Etimicin sulfate, a fourth-generation aminoglycoside antibiotic, is now widely used in clinical settings because of its high efficacy and low toxicity.</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>Eprinomectin B1b is a minor component and belongs to the avermectin family of insecticides and anthelmintics.</p>

<p>Maximin 1, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>CHEMBL1380345 fights S. aureus, B. cereus, E. coli; pMICs: 3.64, 3.56, 3.70.</p>

<p>Antifungal Antibacterial agent 84 targets CNB1 to thwart C. albicans biofilm.</p>

<p>Antibacterial agent 12 targets antibiotic-susceptible/resistant Gram-positive bacteria.</p>

<p>Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba &amp;amp; Aplysina aerophoba.</p>

<p>Amdoxovir is a reverse transcriptase inhibitor.</p>

<p>Dactylfungins B, an antifungal by Dactylaria Parvispora, inhibits Candida and others at &lt;10 µg/ml.</p>

<p>HLA-A*0301-restricted epitope from Epstein-Barr Virus , EBV BRLF-1 (148-156).</p>

<p>Showdomycin is an antibiotic with antineoplastic activity.</p>

<p>Triphala: Ayurvedic mix, blocks NF-κB, antifungal, anti-inflammatory, fights fat &amp; cancer.</p>

<p>Oligomycin C is an antifungal agent isolated from Streptomyces strain.</p>

<p>Ochratoxin C is a toxic metabolite from Aspergillus orchraceus.</p>

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>

<p>m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].</p>

<p>Leucanicidin: a macrolide from S. halstedii, toxic to L. separata larvae at 20 ppm; LD50: 0.23-0.42 µg/ml for some worms.</p>

<p>Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function</p>

<p>Kalimantacin A: a potent antibiotic effective against MRSA and other staphylococci.</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>

<p>Thiocoraline: depsipeptide, DNA intercalator, antibacterial, anticancer, targets Gram-positive, inhibits polymerases, cytotoxic to cancer cells.</p>

<p>(R)-Dinotefuran, a neonicotinoid, is 1.7-2.4x more effective against pests like Aphis gossypii and safer for bees.</p>

<p>Norbatzelladine L inhibits Pdr5p with IC50 3.8µM; shows antifungal, antiparasitic, antiviral, antibacterial, and antitumoral properties.</p>

<p>PF 5081090 has a wide range of applications in life science related research.</p>

<p>1-Phenylhexane exhibits antibacterial and antioxidant activity, inhibiting S. aureus, Pseudomonas aeruginosa, Proteus mirabilis, E. coli, and Bacillus cereus</p>

<p>Picromycin is a macrolide antibiotic and PREP inhibitor effective against gram-positive bacteria, including mycobacteria.</p>

<p>Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.</p>

<p>(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.</p>

<p>SARS-CoV-2-IN-109 (compound 50) is an inhibitor targeting SARS-CoV, demonstrating in vivo anti-infection activity. It interferes with the interaction between the SARS-CoV-2 Spike receptor-binding domain (RBD) and the human receptor angiotensin-converting enzyme 2 (ACE2) with an EC50 of 26.5 μM, effectively blocking SARS-CoV-2 entry into VeroE6 cells (ECS50=17.0 μM). The compound has a CC50 greater than 100 μM in VeroE6 cells.</p>