Microbiology/Virology

<p>Dermcidin-1L (human), an antibiotic peptide secreted by sweat glands, exhibits antimicrobial activity and is utilized in the research of inflammatory skin</p>

<p>Tetramycin (Tetramycin A) is a macrolide antibiotic isolated from Streptomyces hygrospinosus var. Beijingensis, a new and highly effective polyene antibiotic.</p>

<p>Crotalicidin, obtained from rattlesnake venom, is both an antimicrobial and anti-tumor peptide with potent efficacy against Gram-negative bacteria and cancerous</p>

<p>MAPI is an irreversible peptidyl 3C cysteine protease (SV3CP) inhibitor. By covalently attaching its C-terminal Michael acceptor moiety to the active site thiol of SV3CP Cys 139, MAPI inhibits SV3CP. It shows potential for use in the study of norovirus infections.</p>

<p>POLRMT-IN-1 (compound S7) is an inhibitor of POLRMT, specifically utilized in cancer-related research.</p>

<p>Picoxystrobin, a strobilurin fungicide, halts mitochondrial respiration in plants by blocking electron transfer.</p>

<p>CEF1, M1 (58-66) epitope from influenza A; GILGFVFTL is HLA-A2-restricted.</p>

<p>Orazamide may be useful to treat chronic hepatitis and various skin diseases.</p>

<p>1-Methoxy-3-methylbenzene is a potential acetylcholinesterase inhibitor identified through QSAR (quantitative structure-activity relationship) analysis</p>

<p>HSGN-218: non-cytotoxic, gut-specific antibiotic; effective against C. difficile (MIC 0.003-0.03 μg/ml); boosts survival in mice with C. difficile.</p>

<p>Neuraminidase-IN-16 (43b) inhibits H5N1, H5N8, H1N1, H3N2, H5N1-H274Y, H1N1-H274Y neuraminidases; IC50: 0.031-10.08 μM.</p>

<p>Prumycin dihydrochloride is an agent of antifungal antibiotic.</p>

<p>Antibacterial agent 61 (example 27) is a antibacterial agent.</p>

<p>γ-Rubromycin is a natural product derived from Streptomyces bacteria and possesses antimicrobial activity.</p>

<p>Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins.</p>

<p>Suricapavir is an effective viral replication inhibitor with antiviral activity.</p>

<p>Hexylene glycol (Diolane), colorless liquid, is a chiral diol. It is an industrial compound produced from diacetone alcohol by hydrogenation.</p>

<p>Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] .</p>

<p>Piampicillin Hydrochloride is a Hydrochloride form of an oral active ampicillin new spray with antimicrobial activity.</p>

<p>CSP1: potent ComD1 receptor agonist, IC50 of 10.3 nM, important in S. pneumoniae transformation, and has antibacterial properties.</p>

<p>Detoxin C1 is a selective blasticidin S antagonist.</p>

<p>PP102, an antimicrobial peptide, exhibits activity against gram-positive bacteria, including B.</p>

<p>VPC162134 is an antibacterial agent that inhibits H. pylori, C. jejuni, MRSA, and S. epidermidis with minimum inhibitory concentrations (MIC) of 2.9, 17.5, 93.3, and 93.3 μM, respectively. Additionally, VPC162134 acts as an inhibitor of the enzyme pyruvate ferredoxin oxidoreductase (PFOR).</p>

<p>13-Deoxycarminomycin is an antitumor antibiotic.</p>

<p>Albonoursin is used as an antibacterial cyclic dipeptide.</p>

<p>LAH4 acetate is the α-helical structure of the designed amphoteric peptide antibiotic, which is capable of complexing DNA, associating with the cell surface</p>

<p>Allosamidin, a chitinase inhibitor and typical secondary metabolite of Streptomyces, may be used as a pesticide and anti-asthmatic agent.</p>

<p>AIP-II is a macrocyclic peptide signaling molecule produced by Staphylococcus aureus for quorum sensing. It binds to the AgrC-II receptor, regulating the expression of virulence genes within Staphylococcus aureus. Additionally, AIP-II acts as an antagonist to the AgrC-I receptor.</p>

<p>Antitubercular agent-41是一种抗菌剂。</p>

<p>Himastatin, an antitumor antibiotic from S. hygroscopicus, is a dimeric cyclohexadepsipeptide with piperazic acid and a unique aromatic core.</p>

<p>Carbazomycin D, from Streptomyces, fights fungi T. asteroides and T. mentagrophytes, M. tuberculosis, and is cytotoxic to various cells.</p>

<p>4-Acetylbutyric acid is a ketone acid widely used in biochemical experiments and drug synthesis research.</p>

<p>Josamycin propionate is a macrolide antibiotic.</p>

<p>Lobendazole is a metabolite of thiophanate.</p>

<p>Janthitrem G is a type of naphthopyran. Janthitrem G is obtained from Penicillium janthinellum. Tremorgenic mycotoxi.</p>

<p>SARS-CoV-2 Mpro-IN-38 (2-5a) is an inhibitor of SARS-CoV‑2 Mpro with an IC50 value of 0.0435 μM.</p>

<p>Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.</p>

<p>FLDKFNHEAEDLFYQSSL is an 18-residue peptide that binds to the SARS-CoV-2 receptor-binding domain (RBD). It inhibits the entry of SARS-CoV-2 and also interacts with binding residues (Leu455, Phe456, Ala475, and Gln493).</p>

<p>Dendryphiellin D from Septoria rudbeckiae fungus inhibits NO production.</p>

<p>Antibacterial agent 54 (example 20) is a antibacterial agent.</p>

<p>Ilicicolin F is a useful organic compound for research related to life sciences. The catalog number is T125283 and the CAS number is 22738-98-3.</p>

<p>Mtb-IN-7 (compound R7) is a MAO-A/MAO-B inhibitor with an IC50 greater than 40 μM. It exhibits antibacterial activity against Mycobacterium tuberculosis H37Rv, with a MIC of 2.01 μM.</p>

<p>Amphocil is used to treat patients with invasive fungal infection.</p>

<p>SARS-CoV-2-IN-40 (Compound 19), a SARS-CoV-2 inhibitor, effectively suppresses the infection of Calu3 lung cells by the BA.1 and BA.5 variants, exhibiting half-</p>

<p>Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>Ophiobolin B is a sesterterpene Helminthosporium oryzae metabolite, inhibits proton extrusion from maize coleoptiles.</p>

<p>T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcription</p>

<p>Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba &amp;amp; Aplysina aerophoba.</p>

<p>Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.</p>

<p>Lactoferricin B (4-14), bovine (TFA), a 4-14 residue peptide from lactoferrin, has broad-spectrum antimicrobial properties.</p>

<p>SARS-CoV-2 Mpro-IN-37 (compound 8r) is an inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 value of 0.0199 μM. It exhibits IC50 values of 0.00945 μM against SARS-CoV-1 Mpro and 0.111 μM against MERS-CoV Mpro. SARS-CoV-2 Mpro-IN-37 demonstrates potent antiviral activity in the nanomolar range without showing cytotoxicity.</p>

<p>(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid.</p>

<p>NK 1971 is a bioactive chemical.</p>

<p>Clenpirin is a bio-active chemical.</p>

<p>Cinerubin B is a glycosylated anthracycline antibiotic that exhibits anticancer activity. It is derived from Streptomyces sp. SPB74.</p>

<p>Antibacterialagent 176 (Compound 6f) is a potent PqsR antagonist. It effectively inhibits Pseudomonas aeruginosa (P. aeruginosa CF), demonstrating significant suppression of pyocyanin and 2-alkyl-4(1H)-quinolone production.</p>

<p>WU-FA-01, a hydrogenated WU-FA-00 derivative, has potent antibacterial effects on Gram-positive strains and anti-inflammatory properties.</p>

<p>Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.</p>

<p>Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.</p>

<p>Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.</p>

<p>MBL-IN-2 ((2R, 2R')-5αC) is a Metallo-β-lactamase (MBL) inhibitor that effectively inhibits New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC50 of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used in research on resistance to β-lactam antibiotics.</p>

<p>S 82-5455 is a floxacrine derivative.</p>

<p>5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.</p>

<p>3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.</p>

<p>(±)-Emodin bianthrone (compound 10), a naturally occurring substance, demonstrates antimalarial, antitubercular, and antifungal properties [1].</p>

<p>Ganorbiformin B, a lanostane triterpenoid, is C-3 epimer of ganoderic acid T, active against Mycobacterium tuberculosis.</p>

<p>7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as</p>

<p>PfSUB1-IN-1 (compound 4c) is an inhibitor of Plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1), exhibiting potent activity with an IC50 value of 15 nM. PfSUB1 is a key target in antimalarial research. PfSUB1-IN-1 demonstrates a 13-fold greater inhibitory effect on the growth of transgenic Plasmodium falciparum strains (expressing lower levels of PfSUB1 compared to the wild-type) than on wild-type parasite strains.</p>

<p>Antifungal 1-(4-AMinophenyl)-2(1h)-pyridinone inhibits Candida, Aspergillus, Pseudomonas, and Staphylococcus.</p>

<p>FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescein isothiocyanate (FITC)-labeled segment of the HHV-2 Envelope Glycoprotein G encompassing amino</p>

<p>SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18</p>

<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>

<p>Colistin: polypeptide antibiotic for Gram-negative bacteria, including drug-resistant strains, but may cause nephrotoxicity.</p>

<p>Pantinin-2, a cysteine-free toxic peptide from the emperor scorpion (paninus imperator), exhibits high activity against Gram-positive bacteria and relatively low activity against Gram-negative bacteria. In addition, Pantinin-2 also has some activity against Candida tropicalis and exhibits mild hemolytic activity against human erythrocytes. This compound has the potential to treat drug-resistant pathogens.</p>

<p>Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.</p>

<p>XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.</p>

<p>KN-17, a modified derivative based on the cecropin B structure, effectively disrupts bacterial growth and induces the migration of human bone marrow stromal cells (hBMSCs). This compound significantly stimulates angiogenesis both in vitro and in vivo.</p>

<p>(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.</p>

<p>PF-1163B, from Penicillium sp. II, is an antifungal that blocks ERG synthesis (IC50: 34 ng/ml) and targets Candida albicans without harming mammalian cells.</p>

<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>

<p>4-Deoxy-4α-phorbol, a tetracyclic diterpene identified in E.</p>

<p>N-Demethylvancomycin is a glycopeptide antibiotic that can be extracted from Nocardia orientalis and exhibits activity against various strains of Staphylococcus aureus and Staphylococcus epidermidis. It is utilized in research related to infections.</p>

<p>Collinin, a coumarin in Z. schinifolium, combats M. tuberculosis and inhibits NO production, platelet aggregation, and tumor growth in mice.</p>

<p>Maximin 4, an antimicrobial peptide from Bombina maxima skin secretions, exhibits cytotoxic effects on tumor cells and spermicidal properties [1].</p>

<p>Antiparasitic agent-14: potent, cytotoxic, inhibits trypomastigote and amastigote growth.</p>

<p>This peptide is an H2-Db-restricted epitope from the Influenza A/PR/8/34 nucleoprotein.</p>

<p>Notrilobolide, an alkaloid with insecticidal properties, is isolated from sweet potatoes and impedes larval development in pests such as Tribolium castaneum.</p>

<p>3-(1-Carboxyvinyloxy)benzoic acid is a useful organic compound for research related to life sciences.</p>

<p>(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.</p>

<p>WJM280 is an orally active antimalarial compound with an EC50 of 0.04 μM against the parasite P. falciparum 3D7.</p>

<p>Furaltadone L-tartrate, a nitrofuran, may help study Salmonella enteritidis in chickens; it's an antibacterial agent against staphylococci.</p>

<p>A-73209: nucleoside analog, oxetanocin family, combats herpes simplex and varicella-zoster viruses effectively.</p>

<p>Antifungal agent 81(G22) exhibits excellent antifungal properties, demonstrating an in vitro IC50 value of 0.48 mg/L against Valsa mali.</p>

<p>Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity.</p>

<p>1,3,6-Trihydroxy-5-methoxyxanthone is a useful organic compound for research related to life sciences and the catalog number is T124882.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>GSK3532795: Oral HIV-1 maturation inhibitor, broad virus coverage, EC50: 15 nM, good preclinical pharmacokinetics.</p>

<p>FR-901235, from Paecilomyces carneus, normalizes suppressed lymphocyte growth.</p>