Microbiology/Virology

Cervinomycin A2 is an antibiotic effective against anaerobic bacteria, isolated from the Streptomyces genus, specifically Cervinomycetes. It exhibits strong inhibitory effects on Clostridium perfringens, Peptostreptococcus, and Bacteroides fragilis.

Cefoxitin sodium (Betacef) is a semisynthetic cephamycin antibiotic resistant to beta-lactamase.

1,4-Dihydroxynaphthalene A potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses.

Vasoactive intestinal contractor, a novel member of the endothelin family, stimulates a rapid increase in intracellular Ca2+ concentration in fura-2-overexpressed Swiss 3T3 cells [1.

Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. It exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria, demonstrates inhibitory effects on fungi, and possesses moderate hemolytic activity on human red blood cells. Macropin is utilized in research for anti-infective therapies.

HYNIC-UBI29-41 is composed of the bifunctional chelator HYNIC and the antimicrobial peptide UBI 29-41. It retains the antimicrobial properties of UBI 29-41, showing strong affinity for both Gram-positive and Gram-negative bacteria. When labeled with the radioactive element Technetium (99mTc), HYNIC-UBI29-41 can be used as an imaging agent for detecting bacterial infections in mouse models.

RG7800 hydrochloride is an orally active modulator of SMN2 splicing, exhibiting EC50 values of 23 nM for SMN2 splicing and 87 nM for SMN protein production.

SDH-IN-19 (compound A13) is a fungicide effective against Rhizoctonia solani, with an EC50 value of 0.83 μg/mL. It is utilized in agricultural research for fungal resistance in crops.

LMW peptide, an antimicrobial peptide, exhibits activity against both Gram-positive and Gram-negative bacteria, including B.

RAD51-IN-3 is a Rad51 inhibitor.

Amicoumacin A FA has antimicrobial activity, inhibiting S. purpureus and S. aureus, and can be used in the study of microbial infections.

N-Demethylvancomycin is a glycopeptide antibiotic that can be extracted from Nocardia orientalis and exhibits activity against various strains of Staphylococcus aureus and Staphylococcus epidermidis. It is utilized in research related to infections.

MTH1 ligand 1 functions as a target protein ligand for MTH1, and is utilized in the synthesis of PROTACaTAG 2139.

TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21, utilized as an adjuvant in preventive vaccines. It demonstrates potent adjuvant activity with influenza antigens and shows good tolerability when combined with an acellular pertussis vaccine (aP), enhancing anti-pertussis toxin (PT) antibody responses in mice and rabbits. TQL-1055 holds promise for research into chronic Hepatitis B.

Chitotriose, a low molecular weight chitosan oligosaccharide, is extractable from crab shell chitosan. It exhibits antibacterial properties against salmonella.

Bac8c is an antimicrobial peptide exhibiting potent activity against both Gram-negative and Gram-positive bacteria. The minimum inhibitory concentrations (MIC) of Bac8c for S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 2, 8, 4, 4, and 4 μg/mL, respectively.

JM 1397 is a bioactive chemical.

Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.