Microbiology/Virology

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>NR-NO2 is a prospective therapeutic agent with targeted delivery and image-guided capability for use in antitumor studies, also demonstrating antibacterial</p>

<p>AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).</p>

<p>Antitrypanosomal agent 23 is an antiparasitic compound effective against intracellular amastigotes of Trypanosoma cruzi in LLC-MK2 and C2C12 cells, demonstrating activity with IC50 values of 0.10 and 0.11 μM, respectively. It also acts as a weak inhibitor of recombinant Trypanosoma cruzi sialyltransferase (TcTS) with an IC50 of 1.1 mM.</p>

<p>LCMV nucleoprotein (396-404) is an H-2D(b) epitope, key for studying viral antigens.</p>

<p>Diaporthein B, a potent pimarane diterpene, inhibits M. tuberculosis (MIC: 3.1 μg/mL) and combats colon cancer cells (IC50: 1.5-3 μM/L).</p>

<p>Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).</p>

Cyclacillin (Wy-4508), an oral aminopenicillin, fights many gram-positive/negative bacteria.

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.</p>

<p>Alkaline tryptase-IN-1 (compound H-13) is an insecticide that targets alkaline trypsin-like enzymes. It has lethal concentration (LC50) values of 8.72, 13.77, 14.17, 12.96, and 12.35 μg/mL against Schizaphis graminum, Sitobion avenae, Brevicoryne brassicae, Aphis gossypii, Aphis spiraecola, and Myzus persicae, respectively.</p>

<p>SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 Mpro with an IC50 of 110 nM. This compound demonstrates antiviral activity with an EC50 of 1.6 μM.</p>

<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>

<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>

Loloatin B 10 is a bioactive chemical.

<p>HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.</p>

<p>Neomycin C, less potent isomer of Neomycin complex, is part of a 2-DOS aminoglycoside.</p>

<p>Cefozopran is a fourth-generation cephalosporin.</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>