Microbiology/Virology

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2, a peptide substrate for HIV-1 protease, is used in inhibition assays.

IspE kinase-IN-1 (compound 4) is a potent inhibitor of IspE kinase, exhibiting IC50 values of 6.2 µM against EclspE and 5.2 µM against KplspE.

Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.

Polymyxin E2, a key component of the cationic lipopeptide antibiotic colistin, was originally derived from B.

HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.

ST166 free acid is an inhibitor of the PhoP-DNA complex formation, with IC50 values of 18 μM and 24 μM, effectively hindering the binding of PhoP and MtrAC to DNA. Additionally, ST166 free acid exhibits antibacterial activity against Mycobacterium marinum.

Alahopcin is a new dipeptide antibiotic generated by Streptomyces albulus subsp. ochragerus subsp. nov.

RSV-IN-13 (compound 5c) exhibits antiviral activity against RSV with an EC50 value of 0.78 nM. It is utilized in the study of respiratory infections.

Thanatin is an antimicrobial peptide with antifungal properties effective against certain Gram-positive bacteria [1].

AT-9010 tetrasodium, from AT-527, inhibits NiRAN essential for viral replication and stops SARS-CoV-2 spread.

NUDT5/14 antagonist 1 (Compound 9) is a dual selective antagonist for nucleotide diphosphate kinases NUDT5 and NUDT14, exhibiting IC50 values of 0.27 and 0.16 μM, respectively. Additionally, NUDT5/14 antagonist 1 binds to Bruton's tyrosine kinase (BTK) with an IC50 of 0.377 μM.

Peptide T, an HIV-1 derived octapeptide, may inhibit gp120 binding to CD4 and cytokines, and affect VIP receptors.

Succinate dehydrogenase-IN-10 (Compound B5) is an inhibitor of RsSDH (Succinate dehydrogenase in R. solani) with an IC50 of 0.12 μM. It exhibits antifungal activity against R. solani with an EC50 of 0.002 μg/mL and also shows efficacy against P. pachyrhizi.

Julimycin B-II is a type of bioacive chemical.

Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS). This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.

BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.

IDR-1: Antimicrobial peptide, combats Gram-positive/negative bacteria, modulates immunity, non-toxic, anti-inflammatory, regulates chemokines/cytokines.

Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.

HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin.

Altromycin B is a new pluramycin-like antibiotic.