Microbiology/Virology

Antituberculosis agent-5 is a small molecule used for high-throughput assays.

HBV/HDV-IN-4 hydrochloride (Compd 4) serves as an inhibitor of both HBV and HDV, demonstrating an EC 50 of less than 50 nM against HBV.

HCVcc-IN-1, a derivative of benzothiazole-2-thiophene S-glycoside, exhibits low toxicity and antiviral properties [1].

Masavibart (ZRC3308-A7), an IgG1 anti-SARS-CoV-2 mAb, binds RBD on spike protein; pairs with ZRC3308-B10 for COVID-19 prevention.

HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.

Abbeymycin is an antibiotic

DXR-IN-1 (Compound 13E) is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). It exhibits high selectivity for DXR of Plasmodium falciparum with an IC50 of 0.030 μM. DXR-IN-1 impedes the growth of Plasmodium by binding to the active site of DXR and inhibiting its catalytic activity.

Amdoxovir is a reverse transcriptase inhibitor.

Y 14556 is a biochemical.

Cyclopeptide 2 (Compound 2) is a moderately active antimicrobial peptide against B.

NZ-804 is an orally active inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 8.9 nM. It inhibits replication of SARS-CoV-2 in HeLa-hACE2 cells, showing an EC50 of 14 nM. NZ-804 exhibits broad-spectrum antiviral activity against various CoVs and decreases viral replication in mice and hamster models.

Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with activity against *Leishmania donovani*, exhibiting an IC50 value of 5.67 μM and a CC50 value of 3.79 μM in THP-1 cells. This compound is applicable for research in tropical diseases.

M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.

Sarubicin A (U-58431) is an antibiotic capable of inhibiting both Gram-positive and Gram-negative bacteria and exhibits antitumor activity.

BMAP-28, an antibiotic peptide, induces cell death by triggering the mitochondrial permeability transition pore and serves as a research tool in the study of

Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I & II with Ki of 40.9 & 38.0 μM.

GP-2B, an antimicrobial peptide, exhibits antibacterial activity against Gram-positive strains, with a minimum inhibitory concentration (MIC) ranging from 8 to

Compound Fr13414, with CAS No. 13114-72-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13414 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

JG 365 is an HIV protease inhibitor.

23-O-Demycinosyltylosin (23-DMT), an acyl derivative of tylosin, exhibits antibacterial activity [1].

Laidlomycin, a polyether, polycyclic, monocarboxylic acid, possesses inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.

RPR103611, a betulinic acid derivative, inhibits HIV-1; IC50s: CCR5 (YU2) 80, CXCR4 (NL4-3) 0.27, dual-tropic (89.6) 0.17.

Harzianum A: a non-cytotoxic trichothecene from Trichoderma harzianum with modest antifungal properties at 100 μg/mL, inactive against bacteria.

D-Hexamannuronic acid: alginate from brown algae & some bacteria, used in pain and dementia research.

SARS-CoV-2-IN-23: Antiviral diphosphate ester, disrupts membranes; IC50: 8.2 & 2.6 μM; EC50: 4.4 μM.

HIV-1 integrase inhibitor 10: oral ALLINI, blocks NLRepRluc virus in MT-2 cells, EC50 of 3-5 nM, used in HIV-1 research.

Antifungal agent 15 exhibits remarkable potency, with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.

Compound C-2, a non-mutagenic antibacterial against gram-positive/negative bacteria, inhibits protein synthesis.

Polymyxin B2, a significant component of polymyxin B, is an antibiotic cationic lipopeptide initially derived from B.

Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.

Digitolutein is a useful organic compound for research related to life sciences and the catalog number is T124809.

N-3-hydroxydecanoyl-DL-Homoserine lactone activates SdiA in S. enterica (EC50=0.6 μM).

m7GpppGmpG, a trinucleotide 5′ cap analog, exhibits capping efficiencies of 86% for the RNAs obtained [1].

Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.

DNA31 is a potent RNA polymerase inhibitor.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae

Ledoxantrone, a benzopyranoindazole, stabilizes DNA-topoisomerase II complexes and blocks helicases; shows preclinical promise.

Dehydropipernonaline is a useful organic compound for research related to life sciences. The catalog number is T126447 and the CAS number is 107584-38-3.

Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.

NS5A-IN-4 (Compound 1.12) is a hepatitis C inhibitor effective against multiple genotypes, with IC50 values ranging from 1.2 to 2296 pM.

Antimicrobial Agent-10 demonstrates exceptional antibacterial activity and inhibits SARS-CoV-2, positioning it as a potent antimicrobial compound [1].

Geninthiocin A, a cyclic thiopeptide from Streptomyces sp. DD84, targets Gram-positive bacteria, C. violaceum, and M. hiemalis; induces tipA transcription.

PROTACHBeAg degrader-1 is a PROTAC-based targeted degrader of HBeAg. It effectively recruits the VHL E3 ligase, yet its ability to degrade the hepatitis B virus protein (HBeAg) does not depend on VHL recruitment. This compound decreases levels of both secreted and intracellular HBeAg and is suitable for research involving the hepatitis B virus (HBV).

Aureonitol, a fungal metabolite with antiviral properties, hinders influenza A (H3N2 and H1N1) replication and hemagglutination.

Ganoderic acid GS-1, an extensively oxygenated lanostane-type triterpenoid, exhibits anti-HIV-1 protease activities, displaying an IC50 value of 58 μM [1].

Ditiocarb speeds up copper cementation, cuts HIV risk, and boosts high-risk breast cancer immunoresearch.

Furylfuramide (also known as AF-2), a synthetic nitrofuran derivative, can be widely used as a food preservative in Japan.

Daunosamnyl-daunorubicin is used as an antibody conjugate.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Antifungal 1-(4-AMinophenyl)-2(1h)-pyridinone inhibits Candida, Aspergillus, Pseudomonas, and Staphylococcus.