Microbiology/Virology

<p>Quercetin pentaacetate (Pentaacetylquercetin) has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.</p>

<p>AB 3217-B is an anti-mite substance isolated from streptomycete strain.</p>

<p>Kuguacin N is a useful organic compound for research related to life sciences and the catalog number is T126345.</p>

<p>Guanfu base H, a diterpenoid from Aconitum coreanum, inhibits malaria strains TM4/8.2 and K1CB1 with IC50s of 4 μM, 3.6 μM.</p>

<p>Elebsiran sodium is an siRNA targeting hepatitis B and D virus infections [1].</p>

<p>Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.</p>

<p>HIV-1 Inhibitor-59 (Compound I-5b) effectively inhibits both wild-type and mutant strains of HIV-1, with EC50 values ranging from 5.62 to 171 nM.</p>

<p>1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.</p>

<p>AA58 enhances Ceftazidime efficacy by lowering its MIC.</p>

<p>Norselic acid B is a naturally occurring compound that can be isolated from the sponge Crella sp. collected in Antarctica. It demonstrates activity against Leishmania parasites.</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

<p>10,11-Dehydrocurvularin: antibiotic, activates heat shock response, blocks TGF-β, anti-cancer.</p>

<p>CR-8020 is a human-derived IgG1 antibody that targets the influenza A virus H3N2. It binds to the hemagglutinin (HA) of H3N2 strains, with an IC50 of 3.36 nM for A/Brisbane/10/2007 and 0.06 nM for A/Wyoming/3/2003. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>

<p>Antibacterial agent 59 (example 24) is a antibacterial agent.</p>

<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>

<p>SEQ-9 is an orally active inhibitor targeting the Mycobacterium tuberculosis (Mtb) 23S bacterial ribosome, demonstrating an inhibitory concentration (IC50)</p>

<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>

<p>wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.</p>

<p>Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Cardol triene, a phenol in cashew shell liquid, blocks tyrosinase (IC50 22.5 μM) &amp; kills S. mansoni at 50-200 μM; used to make bis-benzoxazines.</p>

<p>BRD5018 is an antimalarial agent.</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>

<p>WAY-329764 is an antibacterial agent.</p>

<p>JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.</p>

<p>Saccharocarcin B was isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp.antibiotica SCC1886.</p>

<p>Actinoidin A is a glycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Cephabacin M6 is a new cephem antibiotic isolated from bacterial.</p>

<p>"Mpro inhibitor N3 hemihydrate blocks SARS-CoV-2's main protease (Mpro), with an EC50 of 16.77 μM and targets various coronaviruses."</p>

<p>NR-NO2 is a prospective therapeutic agent with targeted delivery and image-guided capability for use in antitumor studies, also demonstrating antibacterial</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Agent 46 from patent WO2013030735A1, example 9, is a potent antibacterial with research potential.</p>

<p>MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].</p>

<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>

<p>LCMV nucleoprotein (396-404) is an H-2D(b) epitope, key for studying viral antigens.</p>

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>TSO-13 is an inhibitor of the major cysteine protease Cruzipain found in Trypanosoma cruzi, with an IC50 of 2.2 μM. In Vero cells, TSO-13 also suppresses T. cruzi, exhibiting an IC50 of 1.9 μM.</p>

<p>Alkaline tryptase-IN-1 (compound H-13) is an insecticide that targets alkaline trypsin-like enzymes. It has lethal concentration (LC50) values of 8.72, 13.77, 14.17, 12.96, and 12.35 μg/mL against Schizaphis graminum, Sitobion avenae, Brevicoryne brassicae, Aphis gossypii, Aphis spiraecola, and Myzus persicae, respectively.</p>

<p>LL-37, Human TFA (154947-66-7 free base) is a 37-residue amphipathic helical peptide, the sole human cathelicidin antimicrobial peptide, antibacterial.</p>

<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>

<p>Xanthoquinodin A1, a fungally-derived bioactive, inhibits E. tenella, combats various bacteria, and shows cytotoxicity to cancer cells.</p>

<p>Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.</p>

<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>

<p>Flutianil is a chemical compound from the group of thiazolidines .</p>

<p>HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>Aerocavin is an antibiotic (antibiotic) that exhibits activity against both Gram-positive and Gram-negative bacteria in vitro [in vitro].</p>

<p>Sordarin, from S. araneosa, inhibits fungal EF-2 protein synthesis; effective against C. albicans with varying potency on other species.</p>