Microbiology/Virology

<p>Antibacterialagent 226 (Compound 7f) is an antibacterial agent effective against Staphylococcus aureus strains, including methicillin-resistant S. aureus, with a MIC of 2 μg/mL. It exhibits cytotoxicity towards HEK293 cells with an IC50 of 1.9 μM.</p>

<p>EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.</p>

<p>Amphotericin B trihydrate, a polyene antibiotic, is derived from Streptomyces nodosus fermenter cultures. It exhibits antileishmanial properties.</p>

<p>m-Chloramphenicol, an impurity, hinders bacterial protein synthesis as a potent broad-spectrum antibiotic.</p>

<p>Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function</p>

<p>A 26771B is an antibiotic in the class of macrolide lactone.</p>

<p>Burnettramic acid A: Fungus-derived, fights B. subtilis, S. aureus, C. albicans, S. cerevisiae. Toxic to NS-1 cells, not to fibroblasts.</p>

<p>Melaleuca alternifolia essential oil, derived from the leaves of Melaleuca alternifolia, exhibits bactericidal and anti-inflammatory properties.</p>

<p>A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.</p>

<p>Antibacterial agent 165 (compound 3), a hydroxyquinoline derivative, effectively inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1], demonstrating</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>

<p>Dihydroobionin B exhibits potent (please insert the rest of the sentence for revision).</p>

<p>Amycolatopsin B, from Amycolatopsis, inhibits lung (NCI H460) and colon (SW620) cancer cells, with IC50s of 0.28 μM and 0.14 μM.</p>

<p>Astodrimer: large (~3-4 nm, ~16.5 kDa), negative dendrimer with broad-spectrum antiviral, virucidal, and antibacterial properties.</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).</p>

<p>Lycomarasmine is a bioactive chemical.</p>

<p>Malonomicin is a useful organic compound for research related to life sciences and the catalog number is T124924.</p>

[(Cys(Bzl)84, Glu(OBzl)85)]CD4 (81-92) is a selective HIV-1 inhibitor that blocks the interaction between HIV-1 and CD4 molecules, thereby inhibiting viral infection and cell fusion. At a concentration of 25 μM, it can completely prevent fusion formation [1].

<p>Streptomyces pepsin inhibitor is used as a pepsin inhibitor.</p>

<p>Laidlomycin phenylcarbamate is a semi-synthetic polyether antibiotic.</p>

<p>Clenpirin is a bio-active chemical.</p>

<p>XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication.</p>

<p>Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.</p>

<p>Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Compound PDK0239, with CAS No. 496-15-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0239 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Septamycin is a polycyclic, polyether, monocarboxylic acid antibiotic. Septamycin is isolated from strain of Streptomyces albus.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.</p>

<p>CHEMBL1380345 fights S. aureus, B. cereus, E. coli; pMICs: 3.64, 3.56, 3.70.</p>

<p>CI-39, an NNRTI with EC50 of 3.40 µM, inhibits HIV-1 reverse transcriptase and RNase H, with CC50 &gt;30 µM.</p>

<p>Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite.</p>

<p>Mycinamicin I is a macrolide antibiotic.</p>

<p>Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-</p>

<p>Temporin F exhibits antimicrobial activity against Legionella pneumophila [1].</p>

<p>Apramycin: a veterinary aminoglycoside antibiotic, blocks translocation, binds to eukaryotic/bacterial RNA despite differing key residues.</p>

<p>Maximin 3, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.</p>

<p>Ga(III)protoporphyrin-IX: soluble in MeOH, mimics malaria pigment, has strong antibacterial properties.</p>

<p>Thaxtomin A is a plant toxin that causes the death of plant cells.</p>

<p>PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)</p>

<p>Nybomycin, a fungal metabolite from Streptomyces sp. A717, has antibacterial properties; effective against various bacteria including M. tuberculosis.</p>

<p>Schineolignin B is a useful organic compound for research related to life sciences and the catalog number is T126011.</p>

<p>Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.</p>

<p>Frequentin, an antibiotic from P. frequentans, combats bacteria and fungi; MICs: 200 µg/ml for B. subtilis, 300 for S. aureus.</p>

<p>Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS). This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.</p>

<p>HIV-IN-2 (Compound 100) is a potent inhibitor of HIV, showing potential for research into HIV infection [1].</p>

<p>SARS-CoV-2 3CLpro-IN-30 (compound 29) is a potent inhibitor of the SARS-CoV-2 3CL protease (SARS-CoV-2 3CLpro), with an IC50 of 0.04 μM and an EC50 of 0.3 μM.</p>

<p>Trypacidin, from A. fumigatus, kills B. subtilis, M. bovis, T. cruzi, T. gondii, and induces A549 cell lysis; boosts mouse survival in T. gondii model.</p>