Microbiology/Virology

<p>Antibacterialagent 220 is a potent antibacterial compound that directly disrupts bacterial cell membranes. It is effective against both Gram-positive and Gram-negative bacteria, including resistant strains.</p>

<p>Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.</p>

<p>Chalcomycin is a macrolide antibiotic effective against Gram-positive Staphylococcus aureus and Streptococcus pyogenes. It protects mice from infections caused by various Staphylococcus and Streptococcus strains and exhibits no significant toxicity (LD50&gt;2500 mg/kg).</p>

<p>DOTA-ubiquicidin (29-41) is a derivative of an antimicrobial peptide fragment employed for synthesizing [68Ga]Ga-DOTA-Ubiquicidin29-41, which is subsequently utilized in PET/CT imaging of infection processes. Additionally, DOTA-ubiquicidin (29-41) is applicable in the synthesis and research of radiopharmaceuticals known as radionuclide conjugates (RDC).</p>

<p>DENV ligand 2 is a ligand for the DENV E protein. It is used in the synthesis of the PROTAC degrader ZXH-8-004 and serves as the active form of DENV ligand 1.</p>

SARS-CoV-2 Mpro-IN-17 (compound S5-28) is an orally active, non-covalent inhibitor of SARS-CoV-2 Mpro, with an EC50 value of 1.35 μM. It is applicable for research related to COVID-19.

Mtb-IN-7 (compound R7) is a MAO-A/MAO-B inhibitor with an IC50 greater than 40 μM. It exhibits antibacterial activity against Mycobacterium tuberculosis H37Rv, with a MIC of 2.01 μM.

<p>Gramicidin A (TFA) is a peptide component of Gramicidin, an antibiotic mixture originally isolated from B. brevis. It is a highly hydrophobic channel-forming ion carrier that creates monovalent cation-permeable channels in artificial membranes. Additionally, Gramicidin A (TFA) induces the degradation of hypoxia-inducible factor 1α (HIF-1α).</p>

<p>L-Ent-oxPt IV (L-EOP) is an oxaliplatin-based ferric carrier-platinum conjugate. It selectively targets Escherichia coli and exhibits antibacterial activity through DNA damage.</p>

<p>pppApA sodium is a linear dinucleotide intermediate involved in the enzymatic production of bacterial signaling nucleotide c-diAMP. It is formed by the linkage of two ATP molecules.</p>

Antibacterialagent 181 (Compound 3f) is an effective cationic antibacterialagent (antibacterialagent) with low cytotoxicity. It exhibits a minimum inhibitory concentration (MIC) of 2 μg/mL against both Staphylococcus aureus and Escherichia coli.

<p>MPD2 is a PROTAC compound based on a Cereblon-binding ligand that degrades the main protease MPro of SARS-CoV-2. In 293T cells, it effectively reduces MPro protein levels with a DC50 of 296 nM and shows time-dependent activity. MPD2 exhibits strong antiviral properties against various SARS-CoV-2 strains and has increased potency against Nirmatrelvir-resistant variants. It holds potential for researching SARS-CoV-2 diseases.</p>

<p>SARS-CoV-2-IN-83 (compound C6E) exhibits excellent activity against the SARS-CoV-2 spike protein.</p>

<p>COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with an MIC90 of 26 μM. It disrupts bacterial cell wall and membrane integrity, possesses intracellular permeability, and lacks mitochondrial toxicity.</p>

<p>PLpro-IN-2 (Compound 16) is an inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 value of 0.25 μM.</p>

<p>SARS-CoV-2 Mpro-IN-13 (compound 20j) is a covalent inhibitor of the SARS-CoV-2 main protease (MPro) with an IC50 value of 19.0 nM and exhibits antiviral activity with an EC50 value of 138.1 nM.</p>

<p>Sortase A, S. aureus (SrtA) is found in many Gram-positive bacteria and facilitates the recruitment of cell surface proteins. It plays a crucial role in the attachment of various molecules on the cell surface.</p>

<p>Globomycin derivative G2A (Compound G2A) is an inhibitor of lipoprotein signal peptidase II (LspA), with an IC50 of 604 nM. It exhibits inhibitory activity against E. coli, P. aeruginosa, and A. baumannii, displaying minimum inhibitory concentrations (MIC) ranging from 12.5 to 32 μg/mL.</p>

<p>Antibacterialagent 185 (compound IP-01) is a potent antibacterial agent. It inhibits the polymerization and bundling of filamentous temperature-sensitive mutant Z (FtsZ) by enhancing GTP hydrolysis. Antibacterialagent 185 is effective against Streptococcus pneumoniae and displays a narrow spectrum of activity.</p>

<p>Herbimycin C (AntibioticTAN 420D) is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells, with IC50 values of 7.3 and 1.2 μg/mL, respectively.</p>

<p>β-Lactamase-IN-9 (compound 2) is an inhibitor of β-lactamase, capable of restoring the sensitivity of pathogens to β-lactam antibiotics.</p>

<p>Antibacterialagent 226 (Compound 7f) is an antibacterial agent effective against Staphylococcus aureus strains, including methicillin-resistant S. aureus, with a MIC of 2 μg/mL. It exhibits cytotoxicity towards HEK293 cells with an IC50 of 1.9 μM.</p>

<p>Dixanthogen (Auligen) is an ectoparasiticide. Dixanthogen is a thiocarbonyl compound.</p>

<p>Leucinostatin B is a peptide antibiotic from Paecilomyces lilacinus A-267.</p>

<p>A-73209: nucleoside analog, oxetanocin family, combats herpes simplex and varicella-zoster viruses effectively.</p>

<p>3-(1-Carboxyvinyloxy)benzoic acid is a useful organic compound for research related to life sciences.</p>

<p>Niddamycin is a new macrolide antibiotic.</p>

<p>Thermopterin is isolated from Methanoculleus thermophilic.</p>

<p>Negamycin is an agent of broad-spectrum antibacterial that acts by inhibiting protein synthesis.</p>

<p>Phebestin is an aminopeptidase N inhibitor, produced by Streptomyces sp. MJ716-m3.</p>

<p>FR-008I is an antibiotic.</p>

<p>UK 88947 is a protease inhibitor.</p>

<p>Iturin A2 is a useful organic compound for research related to life sciences. The catalog number is T124119 and the CAS number is 83785-07-3.</p>

<p>BU-2313 A is a new antibiotic complex. It also active against anaerobes.</p>

<p>Kasugamycin sulfate is a bioactive chemical.</p>

<p>Lactivicin is a non-beta-lactam antibiotic that acts by binding to penicillin-binding proteins.</p>

<p>A 269A is an antibiotic isolated from broth of Streptomyces sp., strain.</p>

<p>Cefpimizole sodium is a Semisynthetic cephalosporin with antibacterial activity.</p>

<p>Rifametane is a new semi-synthetic rifamycin, an antibiotic produced naturally by the bacterium Amycolatopsis rifamycinica.</p>

<p>BAY38-7690, a hepatitis B virus inhibitor, may have potential for future therapeutic regimens to combat chronic HBV infection.</p>

<p>Lentinellic acid, derived from Lentinellus species (Basidiomycetes), is an antimicrobial and cytotoxic sesquiterpenoid and biologically active protoilludane.</p>

<p>Trimetharba is a kind of insecticide.</p>

<p>Antibiotic SF 2132 is a bioactive chemical.</p>

<p>Leucinostatin K is a new peptide antibiotic from Paecilomyces lilacinus.</p>

<p>DS-8587 is a DNA topoisomerase inhibitor, effective against drug-resistant A. baumannii and F. necrophorum in mice; efflux pump inhibitors don't alter its MIC.</p>

<p>Mycinamicin I is a macrolide antibiotic.</p>

<p>Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.</p>

<p>AB023b is an antibiotic with antifungal properties.</p>

<p>Dactylarin: cytotoxic antibiotic from Dactylaria lutea, interacts with thiols, inhibits glycolytic enzymes.</p>

<p>Polymyxin D2 is a cationic lipopeptide antibiotic against many species of Gram-negative bacteria.</p>