Microbiology/Virology

UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase (UGDH). The human UGDH (hUGDH) is a hexamer that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid. It exists in an active (E) state and an inactive (EΩ) state, which requires binding with the allosteric inhibitor UDP-xylose (UDP-Xyl) to stabilize the inactive form. UX4O may also serve as a physiologically relevant inhibitor of bacterial allosteric UGDH that does not produce UDP-Xyl.

AIP-II is a macrocyclic peptide signaling molecule produced by Staphylococcus aureus for quorum sensing. It binds to the AgrC-II receptor, regulating the expression of virulence genes within Staphylococcus aureus. Additionally, AIP-II acts as an antagonist to the AgrC-I receptor.

1-Isomangostin hydrate, a natural product extracted from the Mangosteen vine, exhibits antifungal activity.

AI 3-16787 is an HIV-1 integrase inhibitor exhibiting inhibitory activity against strand transfer in the presence of Mn²⁺.

EBVEBNA3B (416-424) is an HLA-A11-restricted antigenic peptide derived from the EBVEBNA3B protein.

Pantinin-2, a cysteine-free toxic peptide from the emperor scorpion (paninus imperator), exhibits high activity against Gram-positive bacteria and relatively low activity against Gram-negative bacteria. In addition, Pantinin-2 also has some activity against Candida tropicalis and exhibits mild hemolytic activity against human erythrocytes. This compound has the potential to treat drug-resistant pathogens.

Corallopyronin A is an antibiotic that can be isolated from *Corallococcus coralloides* [1].

Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. It exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria, demonstrates inhibitory effects on fungi, and possesses moderate hemolytic activity on human red blood cells. Macropin is utilized in research for anti-infective therapies.

Hc-CATH (Sea snake cathelicidin) is a broad-spectrum antibacterial peptide effective against Shigella dysenteriae and Klebsiella pneumoniae, with MIC values ranging from 0.16 to 20.67 mM. Additionally, Hc-CATH demonstrates anti-inflammatory efficacy.

Compound 480-68-2, with CAS No. 480-68-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 480-68-2 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.

Antifungalagent 96 (Compound WZ-2) is an antifungal agent with excellent blood-brain barrier permeability and brain penetration. It inhibits the growth of C. neoformans H99 and C. albicans 0304103, with MIC values of 0.016 and 32 μg/mL, respectively.

SARS-CoV-2 Mpro-IN-13 (compound 20j) is a covalent inhibitor of the SARS-CoV-2 main protease (MPro) with an IC50 value of 19.0 nM and exhibits antiviral activity with an EC50 value of 138.1 nM.

Globomycin derivative G2A (Compound G2A) is an inhibitor of lipoprotein signal peptidase II (LspA), with an IC50 of 604 nM. It exhibits inhibitory activity against E. coli, P. aeruginosa, and A. baumannii, displaying minimum inhibitory concentrations (MIC) ranging from 12.5 to 32 μg/mL.

AcrAP2 is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). It exhibits inhibitory effects on Gram-positive bacteria and yeast while generally showing no activity against Gram-negative bacteria. The cationic-enhanced analogue of AcrAP2 (AcrAP2a) has demonstrated significant antiproliferative effects on certain human cancer cell lines at low concentrations. AcrAP2 holds potential for research in antibacterial and antitumor applications.

Dixanthogen (Auligen) is an ectoparasiticide. Dixanthogen is a thiocarbonyl compound.

Carfecillin Sodium, a phenyl ester of Carbenicillin, becomes an active antibacterial in intestines, treating urinary infections.

KRH-3955, a CXCR4 antagonist, is an orally bioavailable and extremely potent inhibitor of HIV-1 infection.

Enniatin F is a natural product that can be used as a reference standard. The CAS number of Enniatin F is 144446-20-8.

Niddamycin is a new macrolide antibiotic.

(-)-Isopinocampheol is a monoterpene and a component of several plant essential oils. It showed dual viricidal activity against herpes simplex virus 1.

GSK3532795: Oral HIV-1 maturation inhibitor, broad virus coverage, EC50: 15 nM, good preclinical pharmacokinetics.

AC 4437 is an aminoglycoside antibiotic.

Heneicomycin is a precursor antibiotic of Aurodoxin.

BU-2313 A is a new antibiotic complex. It also active against anaerobes.

Kijimicin is a polyether antibiotic and human immunodeficiency virus inhibitor in acutely and chronically infected cells.

A 269A is an antibiotic isolated from broth of Streptomyces sp., strain.

Rifametane is a new semi-synthetic rifamycin, an antibiotic produced naturally by the bacterium Amycolatopsis rifamycinica.

BAY38-7690, a hepatitis B virus inhibitor, may have potential for future therapeutic regimens to combat chronic HBV infection.

Lentinellic acid, derived from Lentinellus species (Basidiomycetes), is an antimicrobial and cytotoxic sesquiterpenoid and biologically active protoilludane.

Mycinamicin I is a macrolide antibiotic.

AB023b is an antibiotic with antifungal properties.

Dactylarin: cytotoxic antibiotic from Dactylaria lutea, interacts with thiols, inhibits glycolytic enzymes.

Linearolactone, isolated from Salvia polystachya, inhibits Entamoeba histolytica and Giardia lamblia.

Landomycin A is a prominent angucycline hexasaccharide antibiotic from Streptomyces sp.

NL3 is an inhibitor of bacterial cystathionine gamma-lyase, exhibiting IC50 values of 0.7 μM for [bCSE] and 3.4 μM for [hCSE]. It is applicable in research focused on antibacterial activity and overcoming bacterial resistance.

SARS-CoV-2 Mpro-IN-26 (compound 13) is a covalent inhibitor targeting SARS-CoV-2 Mpro.

NEU3-IN-2 (compound 963), a derivative of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and a C9 biphenylcarbamate, functions as an inhibitor of NEU3, a human neuraminidase with four isozymes. This compound exhibits inhibitory activity with a Ki of 0.12 μM and an IC50 of 0.31 μM. It serves as a crucial tool in the exploration of NEU3 isozyme functionality. Additionally, its analogs, featuring an amide and a triazole linker, show selectivity towards NEU1 and NEU4 isozymes, respectively.

LasR-IN-5 (compound 3C) acts as an antagonist of LasR with an IC50 of 1.37 μM, exhibiting a 77% inhibition in the formation of Pseudomonas biofilms. Moreover, LasR-IN-5 also demonstrates inhibitory activity against quorum sensing (QS) and is applicable in infection research.

Laccase-IN-4 (compound 5g) exhibited significant laccase inhibitory activity.

DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I.

Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.

Prumycin dihydrochloride is an agent of antifungal antibiotic.

Pelagiomicin A is used as an anticancer antibiotic produced by the marine bacterium Pelagiobacter variabilis.

Mps1-IN-9 (compound M-12) is a targeted Mps1 drug discovered for broad-spectrum antifungal medication use.

Deltamycin A1 is a novel macrolide antibiotic.

Granatomycin B is a useful organic compound for research related to life sciences. The catalog number is T124348 and the CAS number is 71203-18-4.