Microbiology/Virology

Polymyxin B2, a significant component of polymyxin B, is an antibiotic cationic lipopeptide initially derived from B.

N-3-hydroxydecanoyl-DL-Homoserine lactone activates SdiA in S. enterica (EC50=0.6 μM).

Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .

Ledoxantrone, a benzopyranoindazole, stabilizes DNA-topoisomerase II complexes and blocks helicases; shows preclinical promise.

BCX-1898: Oral cyclopentane-based neuraminidase inhibitor for flu A/B; EC50 <0.01-21µM; effective in mouse models.

Emestrin, a mycotoxin with antimicrobial and immunomodulatory properties, combats various pathogens and can induce tissue necrosis.

PROTACHBeAg degrader-1 is a PROTAC-based targeted degrader of HBeAg. It effectively recruits the VHL E3 ligase, yet its ability to degrade the hepatitis B virus protein (HBeAg) does not depend on VHL recruitment. This compound decreases levels of both secreted and intracellular HBeAg and is suitable for research involving the hepatitis B virus (HBV).

SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (

JM 1397 is a bioactive chemical.

Potassium Clavulanate Mixture with Silicon Dioxide (1:1) is a compound consisting of an equal parts ratio, specifically one part Potassium Clavulanate to one

A 25794 is an antibiotic with possible antidepressant properties.

Succinate dehydrogenase-IN-7 (Compound 2f) is a succinate dehydrogenase inhibitor with an IC50 value of 2.51 μM and exhibits bactericidal properties.

Y 12896 has a wide range of applications in life science related research.

Metam-sodium: organic salt, yellow-green, smells of amine/sulfur; used as herbicide, insecticide, fungicide, pesticide.

Cellocidin inhibits gammaherpesvirus-related B-lymphoma growth via NF-κB and c-Myc pathways.

Helvolinic acid is a useful organic compound for research related to life sciences. The catalog number is T126540 and the CAS number is 10072-61-4.

7-Methoxy-β-carboline-1-propionic acid (compound 46), known for its cytotoxic and antimalarial properties, is derived from the roots of Eurycoma longifolia [1].

Furylfuramide (also known as AF-2), a synthetic nitrofuran derivative, can be widely used as a food preservative in Japan.

(+)-Carbovir triphosphate, Abacavir's active metabolite, studied for HIV-1 resistance and inhibition mechanisms.

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

SARS-CoV-2-IN-27: bifunctional diphosphate ester, C6 alkyl, molecular tweezers, antiviral (IC50: 1-1.7μM), disrupts membranes (EC50: 6.5μM).

A 83016F, an antibiotic from an actinomycete designated A83016, exhibits weak antimicrobial activity.

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Fusionglycoprotein92-106 is a peptide derived from the respiratory syncytial virus (RSV) fusion protein. It functions as an MHC class I-restricted cytotoxic T lymphocyte (CTL) epitope, with all 15 amino acids effectively recognized by CTLs.

Mildiomycin, an antibiotic from Streptoverticillium, targets barley mildew, some Mycobacterium, Rhodotorula, but not most fungi/bacteria.

Pelteobagrin is a broad-spectrum antimicrobial peptide targeting Gram-positive bacteria, Gram-negative bacteria, and fungi (MIC=2-16 μg/mL). It exerts its bactericidal effects by non-competitively disrupting the integrity of cell walls and cytoplasmic membranes. Pelteobagrin holds promise for use in infectious disease research.

Ro 19-9638 is the N-oxide of Ro 15-0216.

RVG29, a peptide originating from Rabies Virus Glycoprotein, specifically targets the α-7 subunit of nicotinic acetylcholine receptors (AchR) on neuronal cells

SEB Domain (152-161) TFA represents amino acid positions 152-161 within the structural domain of staphylococcal enterotoxin B, produced by Staphylococcus aureus. This segment is highly conserved and inhibits the transcytosis of multiple staphylococcal enterotoxins, including SEA, SEE, and TSST-1.

Bis-Br-ANT-ATP(tetrasodium) is a fluorescent derivative of adenosine-5'-triphosphate (ATP). It selectively inhibits the adenylyl cyclase toxin CyaA of Bordetella pertussis with a Ki of 12.6 nM. This compound is utilized in research related to whooping cough.

Schizozygine is an alkaloid isolated from Schizozygia caffaeoides.

Corynecin I, an antibiotic similar to chloramphenicol, fights Gram-positive/negative bacteria; MIC 5.2-83 μg/ml for various species.

S-MGB-234: Novel Minor Groove Binder, potential treatment for animal African trypanosomiasis, effective in mice.

GT-1 (LCB10-0200), a siderophore cephalosporin, fights P. aeruginosa, K. oxytoca, Proteus, S. marcescens, E. aerogenes.

BP-198 is a MproPROTAC degrader that enhances the ubiquitination and degradation of Mpro. It exhibits antiviral activity against SARS-CoV-2 with an IC50 of 11.8 μM and demonstrates increased efficacy against drug-resistant viruses.

Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.

Bacillosporin C, an oxaphenalenone dimer with antibiotic properties, inhibits acetylcholinesterase; derived from mangrove fungus T. bacillosporus.

Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.

(+)-Epieudesmin is an antineoplastic agent with limited inhibitory effects on cancer cell lines and possesses the ability to hinder the growth of Gram-negative

Pezulepistat is a macrolide broad-spectrum antibiotic. It can be utilized in research to study its effects on infections caused by Gram-negative bacteria and other microbial infections.

Urease-IN-9 (Compound 1e), an urease inhibitor with an IC50 of 19.5 μM, effectively impedes the enzyme's activity [1].

Brevinin-1, an antimicrobial peptide, originates from the skin secretions of the European green frog (Rana esculenta) [1].

Acryl42-10 serves as a covalent inhibitor for the SARS-CoV-2 Nsp14 N7-Methyltransferase, exhibiting an inhibition concentration (IC50) of 7 μM [1].

Dactylocyclines: new tetracycline derivatives from Dactylosporangium fermentation, including isolated glycosides.

(+)-Inophyllum B, an HIV Reverse Transcriptase inhibitor, IC50: 38 nM; blocks HIV-1 in vitro, IC50: 1.4 μM; from Achatina fulica.

Blasticidin A, from S. resistomycificus, inhibits A. parasiticus aflatoxin (IC50s: 0.25 μM) but not growth; also halts protein synthesis in S. cerevisiae.

Terpenomycin is a polyene compound isolated from pathogenic Nocardia terpenica strains in humans, exhibiting both cytotoxic and antifungal activities [1].

Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.