Microbiology/Virology

Primordazine NC-6364997 is a negative control for Primordazine A and Primordazine B.

Sesquicillin A: insecticidal antibiotic from white plantain; stops A. salina growth; MIC 6.25 µg/mL.

Benastatin C, from Streptomyces, inhibits GST (IC50=24 μg/ml) & porcine pancreatic lipase (IC50=10 μg/ml), boosts mouse spleen lymphocyte blastogenesis.

Antibacterialagent 270 (Compound 3e) is an antibacterial agent that targets bacterial membrane components such as phosphatidylglycerol (PG), cardiolipin (CL), and bacterial DNA. It disrupts the bacterial membrane structure and binds to DNA, interfering with genetic information transfer. Antibacterialagent 270 holds potential for research into infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

SARS-CoV-2-IN-25 (CP026): Strong inhibitor of spike-driven entry with IC50 at 1.6 μM, affects enveloped viruses, liposomes.

Bacillosporin C, an oxaphenalenone dimer with antibiotic properties, inhibits acetylcholinesterase; derived from mangrove fungus T. bacillosporus.

Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.

Targeting thebacterialsliding clamp peptide 46 TFA is a short peptide that specifically targets the bacterial sliding clamp (SC) and inhibits SC-dependent DNA synthesis.

2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.

2,4-Dichlorobenzenesulfonyl chloride aids in creating cancer/bacteria-fighting nicotinyl arylsulfonylhydrazides.

Cacaoidin, a glycosylated lantibiotic extracted from Streptomyces cacaoi, exhibits strong antibacterial effects against Gram-positive pathogens, notably

HIV-1inhibitor-80 (compound M44) is an HIV-1 inhibitor with an EC50 of 5-148 nM. It demonstrates excellent metabolic stability and low cytotoxicity in human plasma and liver microsomes.

Antituberculosis agent-15 (Compound 18c) is a selective antimycobacterial agent with a minimum inhibitory concentration (MIC) of 0.45 μM against Mycobacterium tuberculosis H37Rv (ATCC 27294) and 0.28 μM against its wild-type strain H37Rv-LP (ATCC 25618). It exhibits potent intracellular inhibitory activity in macrophage infection models, with an IC50 of 0.16 μM. Antituberculosis agent-15 is applicable for tuberculosis research.

2'-Deoxytubercidin 5'-triphosphate (C7dATP) sodium is a deoxyadenosine triphosphate (dATP) analog designed to reduce electrophoretic mobility anomalies caused by compression at G or A residues, thereby enhancing the quality of DNA sequencing data.

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker, commonly employed in the synthesis of antibody-siRNA conjugates.

Z-Antiepilepsirine, an amide alkaloid from Piper capense L.f, has antiplasmodial properties with an IC50 of 27 µM against Plasmodium falciparum W2.

Leucanicidin: a macrolide from S. halstedii, toxic to L. separata larvae at 20 ppm; LD50: 0.23-0.42 µg/ml for some worms.

AR-201 is a human IgG1 monoclonal antibody that targets the F glycoprotein F0. It exhibits activity against the respiratory syncytial virus (RSV) and can be utilized in studies related to lower respiratory tract infections (LRTI). The recommended isotype control is HumanIgG1kappa, Isotype Control.

Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.

Tenofovir-C3-O-C12 has a longer half-life, potent anti-HIV effects, and better pharmacokinetics than tenofovir.

Antituberculosis agent-9 (Compound 5a), an orally administered compound, demonstrates potent antitubercular activity, exhibiting a minimum inhibitory

MurA-IN-5 (compound 4c) demonstrates a minimum inhibitory concentration (MIC) of 1.95 μg/mL against Escherichia coli and exhibits significant potency as a MurA inhibitor with an IC50 of 3.77 μg/mL. It also shows antibiofilm activity against various microorganisms, indicating its potential in combating biofilm-related infections.

NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.

CK 683A is a bio-active chemical.

2-Bromoaldisine, a pyrrole alkaloid isolated from Stylissa carter, is known to inhibit HIV-1 infection and suppress the Raf/MEK/MAPK pathway.

Chartreusin sodium is a biochemical.

Peniterphenyl A from deep-sea Penicillium blocks HSV-1/2 entry by targeting glycoprotein D, hindering adsorption and fusion.

Antibiotic LB 10517 is a catechol-substituted cephalosporin with a broad spectrum of antibacterial.

BO-1236 is an antipseudomonal cephalosporin.

Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].

c(R3W4V) is an antimicrobial peptide with a stable transmembrane structure. It exhibits inhibitory concentrations (IC50) of 0.27 μM for E. coli, 0.46 μM for S. aureus, and 0.05 μM for B. subtilis.

Sannamycin B is a bioactive chemical.

AA 57 is an antibiotic.

Emoquine-1 is a potent orally active antimalarial agent effective against various drug-resistant Plasmodium strains, including artemisinin-resistant dormant parasites. It demonstrates efficacy against proliferative malignant Plasmodium with an IC50 value ranging from 20 to 55 nM. Emoquine-1 holds potential for treating Plasmodium strains resistant to artemisinin combination therapy (ACT), with the capability to eradicate persistent parasites.

Angolamycin is a macrolide antibiotic (antibiotic) effective against Gram-positive bacteria.

RSV-IN-11 (compound 10b) exhibits antiviral activity against RSV, with an IC50 value of 4 μM. It is applicable for research on respiratory infections.

10-Norparvulenone, a fungal metabolite from Microsphaeropsis, inhibits viral sialidase and boosts survival in flu-infected MDCK cells at 1 μg/ml.

Tte UvrD Helicase is a thermostable UvrD helicase initially isolated from Thermoanaerobacter tengcongensis. This enzyme can unwind DNA duplexes that have 3' or 5' single-stranded DNA tails, as well as DNA substrates with blunt ends.

Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.

Potassium clavulanate cellulose is a mixture of potassium clavulanate and cellulose, is an inhibitor of beta-lactamase.

Compound YJ196 (Compound 59) serves as an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) [1].

Tetrachloroveratrole forms from chloroguaiacols' degradation, byproducts of wood pulp bleaching in paper production.

Carbendazim mixture with flusilazole is a bioactive chemical.

(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.

A-315675 is a neuramidase inhibitor with anti-infuenza activity.

Antifungalagent 117 is a bipyrrole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. This compound induces cell death by increasing cell membrane permeability, causing an imbalance in osmotic pressure between the interior and exterior of the cell. It also promotes oxidative damage to the cell membrane by inducing the accumulation of reactive oxygen species (ROS), leading to the leakage of cellular contents. RNA sequencing analysis has demonstrated that Antifungalagent 117 disrupts cell membrane structure by downregulating catalase genes and upregulating neutral ceramidase genes, accelerating ceramide metabolism and hastening cell death. The compound holds significant potential for application in plant protection and the control of fungal infections.

FITC-LC-TAT (47-57) acetate is an FITC-labeled TAT peptide known as a cell-penetrating peptide (CPP). It enhances the yield and solubility of heterologous proteins.

Guignardone K, a meroterpene compound extracted from solid cultures of the endophytic fungus Guignardia sp., exhibits antifungal activity [1].

Neuraminidase-IN-16 (43b) inhibits H5N1, H5N8, H1N1, H3N2, H5N1-H274Y, H1N1-H274Y neuraminidases; IC50: 0.031-10.08 μM.