Microbiology/Virology

CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.

Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.

NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.

T-2513 inhibits topoisomerase I by covalently bonding to its DNA complex, blocking DNA replication and causing cell death.

Tomaymycin, an antitumor antibiotic, exhibits antimicrobial activity against Gram-positive bacteria [1] [2].

Antifungalagent 257 (Compound 7e) is a broad-spectrum antifungal agent with an EC50 value of 4.15 μM against F. graminearum.

Efrotomycin: an oral antibiotic from Streptomyces Lactamdurans; minimal effect on Salmonella in pigs.

LpxC-IN-5: potent non-hydroxamate LpxC enzyme inhibitor, IC50=20 nM, antibacterial, with MICs for E. coli, P. aeruginosa, K. pneumoniae at 16, 4, 64, 4 μg/mL.

MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory

(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.

Isogarcinol, a Garcinia-derived immunosuppressant, inhibits T-cell proliferation and exhibits anti-inflammatory and anticancer properties.

Nannochelin B is a siderophore isolated from Nannocystis exedens.

Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.

NOSO-502: Bacterial translation inhibitor, active against Enterobacteriaceae, safe and effective antibacterial.

Mycothiol detoxifies, links foreign compounds, and acts as microbes' glutathione.

Fmoc-L-photo-proline aids in synthesizing cyclic peptidomimetics and peptide-based photoaffinity probes.

Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.

Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.