Microbiology/Virology

Ledoxantrone, a benzopyranoindazole, stabilizes DNA-topoisomerase II complexes and blocks helicases; shows preclinical promise.

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.

Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.

PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an

Agent 47 boosts Ceftazidime's efficacy, lowering its MIC as a potent adjunct antibacterial.

Emestrin, a mycotoxin with antimicrobial and immunomodulatory properties, combats various pathogens and can induce tissue necrosis.

Brevinin-2EC, an antimicrobial peptide sourced from the skin secretions of the European common frog (Rana esculenta) [1], exhibits potent biological activity.

MC12 is a thiazole derivative and an inhibitor of SARS-CoV-2 main protease (IC50: 77.7 nM). It effectively inhibits the main protease of both SARS-CoV and SARS-CoV-2, with low cytotoxicity and good stability. MC12 is suitable for research in anti-COVID-19 drug development.

Maximin 28, an antimicrobial peptide isolated from toad brain tissue, exhibits activity against various bacterial strains, including Staphylococcus aureus,

Compound 24f, an antifungal agent also known as 'Antifungal agent 85,' demonstrates potent antibacterial properties, exhibiting minimum inhibitory concentration

3,3'-((2-Cl-phenyl)methylene)bis(4-OH-2H-chromen-2-one): ENPP1 inhibitor, Ki=50μM; urease inhibitor, IC50=84.53μM.

Terpenomycin is a polyene compound isolated from pathogenic Nocardia terpenica strains in humans, exhibiting both cytotoxic and antifungal activities [1].

Fusionglycoprotein92-106 is a peptide derived from the respiratory syncytial virus (RSV) fusion protein. It functions as an MHC class I-restricted cytotoxic T lymphocyte (CTL) epitope, with all 15 amino acids effectively recognized by CTLs.

Bombinin H5, an antimicrobial peptide originating from the skin of the (moth) Bombina variegata [1], exhibits potent biocidal properties.

Cefazolin is a novel cephalosporin with anti-inflammatory activity and may be used in studies of respiratory tract infections and hepatobiliary infections.

SEB Domain (152-161) TFA represents amino acid positions 152-161 within the structural domain of staphylococcal enterotoxin B, produced by Staphylococcus aureus. This segment is highly conserved and inhibits the transcytosis of multiple staphylococcal enterotoxins, including SEA, SEE, and TSST-1.

Maximin 32, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus and Escherichia coli, with minimum inhibitory

Antibacterial agent 138 effectively targets multi-drug resistant bacteria by inhibiting protein synthesis.

Bis-Br-ANT-ATP(tetrasodium) is a fluorescent derivative of adenosine-5'-triphosphate (ATP). It selectively inhibits the adenylyl cyclase toxin CyaA of Bordetella pertussis with a Ki of 12.6 nM. This compound is utilized in research related to whooping cough.