Microbiology/Virology

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Ethylhexylglycerin (Octoxyglycerin) is a surfactant with moisturizing and lubricating properties.

8-Methoxyquinoline has an antibacterial potential with Ka = 10.2 µM against E. coli R and can be used in related research in the field of life sciences.

SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18

Helvolinic acid is a useful organic compound for research related to life sciences. The catalog number is T126540 and the CAS number is 10072-61-4.

Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.

Compound 5c (Antifungal agent 64) exhibits potent fungicidal activity against Fusarium oxysporum f.sp.

nsP2 Protease-IN-1 is a potent irreversible covalent inhibitor of the nsP2 cysteine protease of the Chikungunya (CHIKV) virus, exhibiting an IC50 of 60 nM. This compound demonstrates strong antiviral activity by inhibiting the replication of CHIKV and Venezuelan equine encephalitis virus (VEEV), with EC50 values of 0.01 µM and 0.3 µM, respectively.

Armentomycin is a kind of chlorinated nonprotein amino acid.

Griselimycin is a natural antimycobacterial product that is currently being pursued as a therapy for tuberculosis.

CAY10742: Oral oxadiazole antibiotic, combats Gram-positive bacteria & MRSA, effective against resistant strains, works in mouse models. MICs = 1-4 μg/ml.

Neocryptomerin is a useful organic compound for research related to life sciences and the catalog number is T125374.

Ashimycin B is a streptomycin analogue that exhibits broad-spectrum antibacterial activity.

Nematicidal Agent 1 is an effective nematicide that binds to the pocket of acetylcholinesterase (AChE).

BRP, a peptide related to BRINP2, exhibits anti-obesity activity through the activation of FOS. It triggers FOS activation in the central nervous system, and its effect is independent of leptin, GLP-1 receptor, and melanocortin 4 receptor.

(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic active against gram-negative pathogens, useful for studying resistant infections.

Ambazone hydrate has anti-cancer activity.

LpxC-IN-5: potent non-hydroxamate LpxC enzyme inhibitor, IC50=20 nM, antibacterial, with MICs for E. coli, P. aeruginosa, K. pneumoniae at 16, 4, 64, 4 μg/mL.