Microbiology/Virology

Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.

Levorin A0 is a Levorin component.

2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.

Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.

Antitubercular agent-52 (Compound 7k) is a chemical compound that acts as an antitubercular agent targeting Mycobacterium tuberculosis (Mtb). It specifically inhibits the bacterium's cytochrome bcc (cyt-bcc) electron transport chain and also affects cytochrome bd (cyt-bd). By disrupting a crucial energy metabolism pathway in Mtb, Antitubercular agent-52 impedes electron transport and ATP production, showing potential for use in tuberculosis research.

Lucanthone N-oxide is a bioactive chemical.

Erythromycin C is a natural product for research related to life sciences. The catalog number is T38084 and the CAS number is 1675-02-1.

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.

Laidlomycin, a polyether, polycyclic, monocarboxylic acid, possesses inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.

Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.

7-Methoxy-β-carboline-1-propionic acid (compound 46), known for its cytotoxic and antimalarial properties, is derived from the roots of Eurycoma longifolia [1].

Mildiomycin, an antibiotic from Streptoverticillium, targets barley mildew, some Mycobacterium, Rhodotorula, but not most fungi/bacteria.

Cletoquine, Hydroxychloroquine's active metabolite, fights CHIKV, has antimalarial properties, and may treat autoimmune diseases.

PF-1163A, a depsipeptide antifungal compound isolated from Penicillium, blocks ergosterol synthesis with an IC50 of 12 ng/ml. This compound specifically inhibits the enzyme ERG25p, a C-4 methyl oxidase in the ergosterol biosynthetic pathway, leading to its antifungal activity. Notably, in Saccharomyces cerevisiae modified to express ERG biosynthesis genes, PF-1163A exhibits an inhibition concentration (MIC value) of 12.5 µg/ml against ERG25p, though strains overexpressing ERG25p show resistance. Additionally, PF-1163A effectively suppresses the growth of Candida albicans (MIC = 8 µg/ml), without affecting other Candida species, Aspergillus fumigatus, or HepG2 cells. Remarkably, it enhances the efficacy of fluconazole against azole-resistant C. albicans strains, showing a significant decrease in MICs (1 and 0.0078 µg/ml alone and in combination, respectively). PF-1163A distinguishes itself from PF-1163B by its more polar nature.

Racemomycin B is a beta-lysine-rich streptothricin antibiotic.

Parasin I (TFA), a peptide derived from the 19 amino acids of histone H2A and isolated from catfish skin, exhibits antimicrobial activity [1].

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a substrate for the WNV NS2B-NS3 protease. It is utilized in the development of selective inhibitors for peptide substrates of the WNV NS2B-NS3 protease.

LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.

Maximin H4, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory activity against a