Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 562 products of "Cyclooxygenase (COX) Inhibitors"
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Deracoxib
CAS:<p>Deracoxib (SC 46) is a selective COX-2 inhibitor, non-steroidal, non-narcotic anti-inflammatory drug with an IC50 of 70-150 μM for osteosarcoma cells.</p>Formula:C17H14F3N3O3SPurity:98.94% - 99.81%Color and Shape:SolidMolecular weight:397.37Guaiacol
CAS:<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Formula:C7H8O2Purity:99.95%Color and Shape:Colourless To Pale Yellow Solid CrystallineMolecular weight:124.14Ketorolac tromethamine salt
CAS:Formula:C19H24N2O6Purity:98%Color and Shape:SolidMolecular weight:376.4037Metamizole sodium hydrate
CAS:<p>Metamizole sodium hydrate (Analgin) is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX).</p>Formula:C13H18N3NaO5SPurity:99.69% - 99.89%Color and Shape:White Or Light Yellow Crystalline Powder Odorless Tiny BitterMolecular weight:351.36(R)-Naproxen
CAS:<p>(R)-Naproxen: anti-inflammatory with antipyretic and analgesic effects; treats gout, dysmenorrhea, rheumatoid arthritis.</p>Formula:C14H14O3Purity:99.62% - 99.94%Color and Shape:SolidMolecular weight:230.262,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-
CAS:Formula:C18H15ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:358.8419Ref: IN-DA002878
1g80.00€5g155.00€10g297.00€1kgTo inquire100g558.00€10mg33.00€500gTo inquire100mg36.00€250mg44.00€Catechin
CAS:<p>Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.</p>Formula:C15H14O6Purity:97.34% - 99.82%Color and Shape:SolidMolecular weight:290.27Tebufelone
CAS:<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Formula:C20H28O2Purity:99.32%Color and Shape:SolidMolecular weight:300.442-O-Sinapoyl makisterone A
<p>Compound 2, formally known as 2-O-Sinapoyl makisterone A, is a sinapinic acid-ecdysterone hybrid that acts as a selective inhibitor of COX-2, effectively</p>Formula:C39H56O11Purity:98%Color and Shape:SolidMolecular weight:700.8615-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Color and Shape:Odour SolidCOX-1/2-IN-5
<p>COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and</p>Formula:C21H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:414.474-ACETAMIDOANTIPYRINE
CAS:<p>4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C13H15N3O2Color and Shape:SolidMolecular weight:245.28COX-2-IN-33
<p>COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent.</p>Formula:C20H13ClF3N5O4Purity:98%Color and Shape:SolidMolecular weight:479.8Pemedolac
CAS:<p>Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.</p>Formula:C22H23NO3Purity:>99.99%Color and Shape:SolidMolecular weight:349.42NF157
CAS:<p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>Formula:C49H28F2N6Na6O23S6Purity:98%Color and Shape:SolidMolecular weight:1437.1COX-1/2-IN-4
<p>COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2.</p>Formula:C22H24N2O2SPurity:98%Color and Shape:SolidMolecular weight:380.5Ketoprofen lysine salt
CAS:<p>Ketoprofen lysine salt is a lysine salt of ketoprofen, a Non-Steroidal Anti-Inflammatory Drug</p>Formula:C22H28N2O5Color and Shape:SolidMolecular weight:400.48SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Formula:C27H23ClN4O3SColor and Shape:SolidMolecular weight:518.11794Anti-inflammatory agent 53
<p>Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest</p>Formula:C24H22N2O4SPurity:98%Color and Shape:SolidMolecular weight:434.51
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