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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 561 products of "Cyclooxygenase (COX) Inhibitors"

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  • Amfenac
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    Amfenac

    CAS:
    <p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>
    Formula:C15H13NO3
    Color and Shape:Solid
    Molecular weight:255.27

    Ref: TM-T1720L

  • AHR-10037
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    AHR-10037

    CAS:
    <p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>
    Formula:C15H13ClN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:288.73

    Ref: TM-T23676

  • Pelubiprofen
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    Pelubiprofen

    CAS:
    <p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>
    Formula:C16H18O3
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:258.31

    Ref: TM-T16464

  • COX-2-IN-2
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    COX-2-IN-2

    CAS:
    <p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>
    Formula:C17H12FN3O2S
    Purity:97.62%
    Color and Shape:Solid
    Molecular weight:341.36

    Ref: TM-T10032

  • COX-2-IN-26
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    COX-2-IN-26

    CAS:
    <p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>
    Formula:C23H21N7OS3
    Color and Shape:Solid
    Molecular weight:507.65

    Ref: TM-T63480

  • Loxoprofenol-SRS tromethamine
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    Loxoprofenol-SRS tromethamine

    CAS:
    <p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>
    Formula:C19H31NO6
    Color and Shape:Solid
    Molecular weight:369.45

    Ref: TM-T72146

  • SC57666
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    SC57666

    CAS:
    <p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>
    Formula:C18H17FO2S
    Purity:98.83%
    Color and Shape:Solid
    Molecular weight:316.39

    Ref: TM-T12860

  • COX-2-IN-14
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    COX-2-IN-14

    CAS:
    <p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>
    Formula:C18H18N4O6
    Color and Shape:Solid
    Molecular weight:386.364

    Ref: TM-T61711

  • COX/5-LOX-IN-1
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    COX/5-LOX-IN-1

    CAS:
    <p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>
    Formula:C18H30O3
    Color and Shape:Solid
    Molecular weight:294.43

    Ref: TM-T60630

  • Thiazolinobutazone
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    Thiazolinobutazone

    CAS:
    <p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>
    Formula:C22H26N4O2S
    Color and Shape:Solid
    Molecular weight:410.53

    Ref: TM-T34846

  • Naproxen etemesil
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    Naproxen etemesil

    CAS:
    <p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>
    Formula:C17H20O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:336.4

    Ref: TM-T16272

  • FR-188582
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    FR-188582

    CAS:
    <p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>
    Formula:C16H13ClN2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:332.8

    Ref: TM-T15345

  • Anti-inflammatory agent 56
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    Anti-inflammatory agent 56

    CAS:
    <p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>
    Formula:C21H15F3N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:476.43

    Ref: TM-T79670

  • MK-0703
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    MK-0703

    CAS:
    <p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>
    Formula:C17H22O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.42

    Ref: TM-T28052

  • COX-2/15-LOX-IN-1
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    COX-2/15-LOX-IN-1

    CAS:
    <p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>
    Formula:C21H21N7S3
    Color and Shape:Solid
    Molecular weight:467.63

    Ref: TM-T62998

  • AL-8417
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    AL-8417

    CAS:
    <p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>
    Formula:C29H34O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.58

    Ref: TM-T23697

  • COX-2-IN-23
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    COX-2-IN-23

    CAS:
    <p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>
    Formula:C24H25N5O3S2
    Color and Shape:Solid
    Molecular weight:495.62

    Ref: TM-T63348

  • COX-2-IN-17
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    COX-2-IN-17

    CAS:
    <p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>
    Formula:C20H23ClN6O2
    Color and Shape:Solid
    Molecular weight:414.89

    Ref: TM-T62142

  • COX-1/2-IN-3
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    COX-1/2-IN-3

    CAS:
    <p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>
    Formula:C14H8N2O8
    Color and Shape:Solid
    Molecular weight:332.22

    Ref: TM-T60992

  • COX-1/2-IN-1
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    COX-1/2-IN-1

    CAS:
    <p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>
    Formula:C15H10BrClN2O
    Color and Shape:Solid
    Molecular weight:349.61

    Ref: TM-T61196