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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 561 products of "Cyclooxygenase (COX) Inhibitors"

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  • COX-2/sEH-IN-1
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    COX-2/sEH-IN-1

    CAS:
    <p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>
    Formula:C23H18F3N5O3S
    Color and Shape:Solid
    Molecular weight:501.48

    Ref: TM-T63398

  • K-80001
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    K-80001

    CAS:
    <p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>
    Formula:C20H17FO2
    Color and Shape:Solid
    Molecular weight:308.35

    Ref: TM-T79181

  • Anti-inflammatory agent 8
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    Anti-inflammatory agent 8

    CAS:
    <p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>
    Formula:C18H15N5OS2
    Color and Shape:Solid
    Molecular weight:381.47

    Ref: TM-T61637

  • Apricoxib
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    Apricoxib

    CAS:
    <p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>
    Formula:C19H20N2O3S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T70018

  • Naproxen glucuronide
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    Naproxen glucuronide

    CAS:
    <p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>
    Formula:C20H22O9
    Color and Shape:Solid
    Molecular weight:406.38

    Ref: TM-T69267

  • COX-2-IN-18
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    COX-2-IN-18

    CAS:
    <p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>
    Formula:C18H19N3O3S2
    Color and Shape:Solid
    Molecular weight:389.49

    Ref: TM-T61760

  • PD 127443
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    PD 127443

    CAS:
    <p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>
    Formula:C20H28N2O
    Color and Shape:Solid
    Molecular weight:312.45

    Ref: TM-T28325

  • COX-2-IN-32
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    COX-2-IN-32

    CAS:
    <p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>
    Formula:C25H24O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.45

    Ref: TM-T79130

  • ASP-6537
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    ASP-6537

    CAS:
    <p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>
    Formula:C17H17N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T23758

  • Pifoxime
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    Pifoxime

    CAS:
    <p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>
    Formula:C15H20N2O3
    Color and Shape:Solid
    Molecular weight:276.33

    Ref: TM-T69473

  • COX-2/5-LOX-IN-3
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    COX-2/5-LOX-IN-3

    CAS:
    <p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>
    Formula:C17H16ClN3O2S
    Color and Shape:Solid
    Molecular weight:361.85

    Ref: TM-T61352

  • COX-2-IN-16
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    COX-2-IN-16

    CAS:
    <p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>
    Formula:C19H12BrN3O2
    Color and Shape:Solid
    Molecular weight:394.22

    Ref: TM-T61821

  • ATB-337
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    ATB-337

    CAS:
    <p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>
    Formula:C23H15Cl2NO2S3
    Color and Shape:Solid
    Molecular weight:504.47

    Ref: TM-T21939

  • COX-2-IN-20
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    COX-2-IN-20

    CAS:
    <p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>
    Formula:C11H9ClFN3O2
    Color and Shape:Solid
    Molecular weight:269.66

    Ref: TM-T60464

  • Prostaglandin G/H synthase 1 inhibitor
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    Prostaglandin G/H synthase 1 inhibitor

    CAS:
    <p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>
    Formula:C13H11ClN2O
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:246.69

    Ref: TM-T27066

  • Flosulide
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    Flosulide

    CAS:
    <p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>
    Formula:C16H13F2NO4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:353.34

    Ref: TM-T11296

  • AHR-6293
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    AHR-6293

    CAS:
    <p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>
    Formula:C15H12ClNO3
    Color and Shape:Solid
    Molecular weight:289.71

    Ref: TM-T23684

  • NCX 466
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    NCX 466

    CAS:
    <p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>
    Formula:C20H24N2O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:436.41

    Ref: TM-T23062

  • Etoricoxib HCl
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    Etoricoxib HCl

    CAS:
    <p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>
    Formula:C18H16Cl2N2O2S
    Color and Shape:Solid
    Molecular weight:395.30

    Ref: TM-T1574L

  • Lobeglitazone Sulfate
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    Lobeglitazone Sulfate

    CAS:
    <p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>
    Formula:C24H26N4O9S2
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:578.61

    Ref: TM-T27841