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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 562 products of "Cyclooxygenase (COX) Inhibitors"

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  • Safrole oxide
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    Safrole oxide

    CAS:
    <p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>
    Formula:C10H10O3
    Purity:100%
    Color and Shape:Solid
    Molecular weight:178.18

    Ref: TM-T34627

  • (-)-Ibuprofenamide
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    (-)-Ibuprofenamide

    CAS:
    <p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>
    Formula:C13H19NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:205.3

    Ref: TM-T11605

  • Piroxicam cinnamate
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    Piroxicam cinnamate

    CAS:
    <p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>
    Formula:C24H19N3O5S
    Color and Shape:Solid
    Molecular weight:461.49

    Ref: TM-T62913

  • GW-406381
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    GW-406381

    CAS:
    <p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>
    Formula:C21H19N3O3S
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T15449

  • COX-2/5-LOX-IN-2
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    COX-2/5-LOX-IN-2

    CAS:
    <p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>
    Formula:C18H13N3O4S2
    Color and Shape:Solid
    Molecular weight:399.44

    Ref: TM-T61910

  • COX-2-IN-19
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    COX-2-IN-19

    CAS:
    <p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>
    Formula:C18H18N4O2S
    Color and Shape:Solid
    Molecular weight:354.43

    Ref: TM-T61264

  • Timegadine
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    Timegadine

    CAS:
    <p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>
    Formula:C20H23N5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:365.5

    Ref: TM-T13160

  • ADU-S100
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    ADU-S100

    CAS:
    <p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>
    Formula:C20H24N10O10P2S2
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:690.54

    Ref: TM-T10252L3

  • COX-2/5-LOX-IN-1
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    COX-2/5-LOX-IN-1

    CAS:
    <p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 &amp; 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>
    Formula:C14H10ClN3O4S2
    Color and Shape:Solid
    Molecular weight:383.83

    Ref: TM-T61674

  • Heterophdoid A
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    Heterophdoid A

    CAS:
    <p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>
    Formula:C26H42O10
    Color and Shape:Solid
    Molecular weight:514.61

    Ref: TM-T63570

  • Naproxcinod
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    Naproxcinod

    CAS:
    <p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>
    Formula:C18H21NO6
    Color and Shape:Solid
    Molecular weight:347.36

    Ref: TM-T33595

  • Nitroflurbiprofen
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    Nitroflurbiprofen

    CAS:
    <p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>
    Formula:C19H20FNO5
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:361.36

    Ref: TM-T16329

  • COX-2-IN-28
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    COX-2-IN-28

    CAS:
    <p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>
    Formula:C30H27N7S3
    Color and Shape:Solid
    Molecular weight:581.78

    Ref: TM-T64109

  • COX-2-IN-11
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    COX-2-IN-11

    CAS:
    <p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>
    Formula:C12H12OS3
    Color and Shape:Solid
    Molecular weight:268.42

    Ref: TM-T60457

  • Naproxen etemesil
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    Naproxen etemesil

    CAS:
    <p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>
    Formula:C17H20O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:336.4

    Ref: TM-T16272

  • Apyramide
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    Apyramide

    CAS:
    <p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>
    Formula:C27H23ClN2O5
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:490.93

    Ref: TM-T10355

  • ABT-963
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    ABT-963

    CAS:
    <p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>
    Formula:C22H22F2N2O5S
    Purity:98% - 99.85%
    Color and Shape:Solid
    Molecular weight:464.48

    Ref: TM-T26531

  • ER-34122
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    ER-34122

    CAS:
    <p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>
    Formula:C27H26ClN3O5
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:507.96

    Ref: TM-T70188

  • Eltenac
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    Eltenac

    CAS:
    <p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>
    Formula:C12H9Cl2NO2S
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:302.18

    Ref: TM-T27254

  • Sudoxicam
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    Sudoxicam

    CAS:
    <p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>
    Formula:C13H11N3O4S2
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:337.37

    Ref: TM-T16950