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Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) Inhibitors

Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.

Found 562 products of "Cyclooxygenase (COX) Inhibitors"

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  • SC57666
    Targetmol
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    SC57666

    CAS:
    <p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>
    Formula:C18H17FO2S
    Purity:98.83%
    Color and Shape:Solid
    Molecular weight:316.39

    Ref: TM-T12860

  • FR-188582
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    FR-188582

    CAS:
    <p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>
    Formula:C16H13ClN2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:332.8

    Ref: TM-T15345

  • Anti-inflammatory agent 56
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    Anti-inflammatory agent 56

    CAS:
    <p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>
    Formula:C21H15F3N4O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:476.43

    Ref: TM-T79670

  • COX/5-LO-IN-1
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    COX/5-LO-IN-1

    CAS:
    <p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>
    Formula:C16H15FN2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:318.37

    Ref: TM-T13263

  • MK-0703
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    MK-0703

    CAS:
    <p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>
    Formula:C17H22O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.42

    Ref: TM-T28052

  • COX-2/15-LOX-IN-1
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    COX-2/15-LOX-IN-1

    CAS:
    <p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>
    Formula:C21H21N7S3
    Color and Shape:Solid
    Molecular weight:467.63

    Ref: TM-T62998

  • COX-2-IN-17
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    COX-2-IN-17

    CAS:
    <p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>
    Formula:C20H23ClN6O2
    Color and Shape:Solid
    Molecular weight:414.89

    Ref: TM-T62142

  • COX-2-IN-23
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    COX-2-IN-23

    CAS:
    <p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>
    Formula:C24H25N5O3S2
    Color and Shape:Solid
    Molecular weight:495.62

    Ref: TM-T63348

  • COX-1/2-IN-3
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    COX-1/2-IN-3

    CAS:
    <p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>
    Formula:C14H8N2O8
    Color and Shape:Solid
    Molecular weight:332.22

    Ref: TM-T60992

  • COX-1/2-IN-1
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    COX-1/2-IN-1

    CAS:
    <p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>
    Formula:C15H10BrClN2O
    Color and Shape:Solid
    Molecular weight:349.61

    Ref: TM-T61196

  • K-80001
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    K-80001

    CAS:
    <p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>
    Formula:C20H17FO2
    Color and Shape:Solid
    Molecular weight:308.35

    Ref: TM-T79181

  • Anti-inflammatory agent 8
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    Anti-inflammatory agent 8

    CAS:
    <p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>
    Formula:C18H15N5OS2
    Color and Shape:Solid
    Molecular weight:381.47

    Ref: TM-T61637

  • Apricoxib
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    Apricoxib

    CAS:
    <p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>
    Formula:C19H20N2O3S
    Color and Shape:Solid
    Molecular weight:356.44

    Ref: TM-T70018

  • COX-2/sEH-IN-1
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    COX-2/sEH-IN-1

    CAS:
    <p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>
    Formula:C23H18F3N5O3S
    Color and Shape:Solid
    Molecular weight:501.48

    Ref: TM-T63398

  • Naproxen glucuronide
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    Naproxen glucuronide

    CAS:
    <p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>
    Formula:C20H22O9
    Color and Shape:Solid
    Molecular weight:406.38

    Ref: TM-T69267

  • AL-8417
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    AL-8417

    CAS:
    <p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>
    Formula:C29H34O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.58

    Ref: TM-T23697

  • PD 127443
    Targetmol
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    PD 127443

    CAS:
    <p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>
    Formula:C20H28N2O
    Color and Shape:Solid
    Molecular weight:312.45

    Ref: TM-T28325

  • COX-2-IN-32
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    COX-2-IN-32

    CAS:
    <p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>
    Formula:C25H24O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.45

    Ref: TM-T79130

  • Thiazolinobutazone
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    Thiazolinobutazone

    CAS:
    <p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>
    Formula:C22H26N4O2S
    Color and Shape:Solid
    Molecular weight:410.53

    Ref: TM-T34846

  • ASP-6537
    Targetmol
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    ASP-6537

    CAS:
    <p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>
    Formula:C17H17N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T23758

  • COX/5-LOX-IN-1
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    COX/5-LOX-IN-1

    CAS:
    <p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>
    Formula:C18H30O3
    Color and Shape:Solid
    Molecular weight:294.43

    Ref: TM-T60630

  • Pifoxime
    Targetmol
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    Pifoxime

    CAS:
    <p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>
    Formula:C15H20N2O3
    Color and Shape:Solid
    Molecular weight:276.33

    Ref: TM-T69473

  • COX-2-IN-16
    Targetmol
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    COX-2-IN-16

    CAS:
    <p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>
    Formula:C19H12BrN3O2
    Color and Shape:Solid
    Molecular weight:394.22

    Ref: TM-T61821

  • COX-2/5-LOX-IN-3
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    COX-2/5-LOX-IN-3

    CAS:
    <p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>
    Formula:C17H16ClN3O2S
    Color and Shape:Solid
    Molecular weight:361.85

    Ref: TM-T61352

  • ATB-337
    Targetmol
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    ATB-337

    CAS:
    <p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>
    Formula:C23H15Cl2NO2S3
    Color and Shape:Solid
    Molecular weight:504.47

    Ref: TM-T21939

  • Flosulide
    Targetmol
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    Flosulide

    CAS:
    <p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>
    Formula:C16H13F2NO4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:353.34

    Ref: TM-T11296

  • AHR-6293
    Targetmol
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    AHR-6293

    CAS:
    <p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>
    Formula:C15H12ClNO3
    Color and Shape:Solid
    Molecular weight:289.71

    Ref: TM-T23684

  • NCX 466
    Targetmol
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    NCX 466

    CAS:
    <p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>
    Formula:C20H24N2O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:436.41

    Ref: TM-T23062

  • Etoricoxib HCl
    Targetmol
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    Etoricoxib HCl

    CAS:
    <p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>
    Formula:C18H16Cl2N2O2S
    Color and Shape:Solid
    Molecular weight:395.30

    Ref: TM-T1574L

  • Lobeglitazone Sulfate
    Targetmol
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    Lobeglitazone Sulfate

    CAS:
    <p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>
    Formula:C24H26N4O9S2
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:578.61

    Ref: TM-T27841

  • LY 25648
    Targetmol
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    LY 25648

    CAS:
    <p>LY 25648 is an antagonist of leukotriene B4.</p>
    Formula:C19H27NO2S
    Color and Shape:Solid
    Molecular weight:333.49

    Ref: TM-T27906

  • ZXX2-77
    Targetmol
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    ZXX2-77

    CAS:
    <p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>
    Formula:C13H13ClN2O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:296.77

    Ref: TM-T24464

  • LY 150310
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    LY 150310

    CAS:
    <p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>
    Formula:C13H14N2
    Color and Shape:Solid
    Molecular weight:198.26

    Ref: TM-T27875

  • PC407-ws
    Targetmol
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    PC407-ws

    CAS:
    <p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>
    Formula:C24H18F3N3Na2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:563.46

    Ref: TM-T24600

  • Isonixin
    Targetmol
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    Isonixin

    CAS:
    <p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>
    Formula:C14H14N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:242.27

    Ref: TM-T27633

  • Prostaglandin G/H synthase 1 inhibitor
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    Prostaglandin G/H synthase 1 inhibitor

    CAS:
    <p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>
    Formula:C13H11ClN2O
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:246.69

    Ref: TM-T27066

  • Tenosal
    Targetmol
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    Tenosal

    CAS:
    <p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>
    Formula:C12H8O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:248.25

    Ref: TM-T13122

  • LY 178002
    Targetmol
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    LY 178002

    CAS:
    <p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>
    Formula:C18H25NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.46

    Ref: TM-T15825

  • L 748780
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    L 748780

    CAS:
    <p>L 748780 is a selective inducible COX-2 inhibitor.</p>
    Formula:C19H14Cl3NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.68

    Ref: TM-T24360

  • Eicosatetraynoic acid
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    Eicosatetraynoic acid

    CAS:
    <p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>
    Formula:C20H24O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:296.4

    Ref: TM-T11169

  • COX-2-IN-20
    Targetmol
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    COX-2-IN-20

    CAS:
    <p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>
    Formula:C11H9ClFN3O2
    Color and Shape:Solid
    Molecular weight:269.66

    Ref: TM-T60464

  • Feprazone
    Targetmol
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    Feprazone

    CAS:
    <p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>
    Formula:C20H20N2O2
    Purity:99.6% - 99.89%
    Color and Shape:Solid
    Molecular weight:320.39

    Ref: TM-T7722

  • Tilmacoxib
    Targetmol
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    Tilmacoxib

    CAS:
    <p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>
    Formula:C16H19FN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:338.4

    Ref: TM-T15630

  • COX-2-IN-1
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    COX-2-IN-1

    CAS:
    <p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>
    Formula:C18H14ClF3N4O2S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:442.84

    Ref: TM-T10033

  • Carpro-AM1
    Targetmol
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    Carpro-AM1

    CAS:
    <p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>
    Formula:C21H18ClN3O
    Color and Shape:Solid
    Molecular weight:363.84

    Ref: TM-T61380

  • Enflicoxib
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    Enflicoxib

    CAS:
    <p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>
    Formula:C16H12F5N3O2S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:405.34

    Ref: TM-T27233

  • Insulin levels modulator
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    Insulin levels modulator

    CAS:
    <p>Insulin level regulators can be used to treat diabetes.</p>
    Formula:C21H23N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.52

    Ref: TM-T11660

  • SC58451
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    SC58451

    CAS:
    <p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>
    Formula:C20H19FO2S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:342.43

    Ref: TM-T12862

  • COX-2-IN-21
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    COX-2-IN-21

    CAS:
    <p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>
    Formula:C21H22N6O4
    Color and Shape:Solid
    Molecular weight:422.44

    Ref: TM-T62259

  • APHS
    Targetmol
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    APHS

    CAS:
    <p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>
    Formula:C15H18O2S
    Color and Shape:Solid
    Molecular weight:262.37

    Ref: TM-T69926