Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 602 products of "Cyclooxygenase (COX) Inhibitors"
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Antioxidant agent-15
CAS:Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.Formula:C19H14O2Purity:98%Color and Shape:SolidMolecular weight:274.31Amtolmetin guacil
CAS:Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。Formula:C24H24N2O5Purity:99.85%Color and Shape:White Needle-Shaped CrystalMolecular weight:420.466-hydroxy Etodolac
CAS:6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.Formula:C17H21NO4Color and Shape:SolidMolecular weight:303.35Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Formula:C16H12ClNO3Purity:98.87%Color and Shape:SolidMolecular weight:301.72Ref: TM-T19679
1mg202.00€1mL*10mM (DMSO)469.00€5mg472.00€10mg707.00€25mg1,035.00€50mg1,311.00€100mg1,663.00€Anticancer agent 166
CAS:Compound 166, also referred to as compound 3, exhibits potent anticancer properties, demonstrating significant inhibitory activity against Caco-2 cells with anFormula:C19H14OSColor and Shape:SolidMolecular weight:290.384'-Aarboxylic acid imrecoxib
CAS:Imrecoxib-4'-carboxylic acid is a metabolite of Imrecoxib, which acts as a selective COX-II inhibitor [1].Formula:C21H21NO5SColor and Shape:SolidMolecular weight:399.46(±)11-HEDE
CAS:"(±)11-HEDE, a racemic mixture comprising the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE, is synthesized from eicosadienoic acid via cyclooxygenase (COX) activity and within macrophages."Formula:C20H36O3Color and Shape:SolidMolecular weight:324.511(R)-HEDE
CAS:11(R)-HEDE is synthesized from 11Z,14Z-eicosadienoic acid through a lipoxygenase-type reaction mediated by COX. Spectrophotometric analysis, specifically measuring the absorbance of the conjugated diene in 11(R)-HEDE, serves as an occasional method for quantifying COX activity.Formula:C20H36O3Color and Shape:SolidMolecular weight:324.5Prostaglandin E2 Ethanolamide
CAS:Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].Formula:C22H37NO5Color and Shape:SolidMolecular weight:395.54BW 755C
CAS:BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.Formula:C10H10F3N3Purity:96.52%Color and Shape:SolidMolecular weight:229.2(-)-Bornyl ferulate
CAS:(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-Formula:C20H26O4Purity:98%Color and Shape:SolidMolecular weight:330.42Thioflosulide
CAS:Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.Formula:C16H13F2NO3S2Purity:>99.99%Color and Shape:SolidMolecular weight:369.41Cimicoxib
CAS:Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.Formula:C16H13ClFN3O3SPurity:98.22%Color and Shape:SolidMolecular weight:381.81Ref: TM-T30937
1mg44.00€2mg55.00€5mg79.00€1mL*10mM (DMSO)96.00€10mg105.00€25mg170.00€50mg255.00€100mg379.00€Thromboxane B3
CAS:Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.Formula:C20H32O6Color and Shape:SolidMolecular weight:368.5(S)-O-Desmethyl Naproxen
CAS:(S)-O-Desmethyl naproxen, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen), is produced through the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.Formula:C13H12O3Color and Shape:SolidMolecular weight:216.23COX-2-IN-7
COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.Formula:C15H13N3O2S2Color and Shape:SolidMolecular weight:331.41COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Formula:C20H27NO6SPurity:99.29% - 99.32%Color and Shape:SoildMolecular weight:409.5COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Formula:C15H15NO3Color and Shape:SolidMolecular weight:257.28Neral
CAS:Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Formula:C10H16OColor and Shape:SolidMolecular weight:152.23COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93
