GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 255 products of "GluR"
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(S)-4CPG
CAS:<p>(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.</p>Formula:C9H9NO4Purity:99.96%Color and Shape:SolidMolecular weight:195.17CX717
CAS:<p>CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.</p>Formula:C11H11N3O3Purity:99.81%Color and Shape:SoildMolecular weight:233.23VU0477886
CAS:<p>VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.</p>Formula:C20H13ClN4O3Purity:98%Color and Shape:SolidMolecular weight:392.80IEM 1754 2HBr
CAS:<p>IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.</p>Formula:C16H30N2·2HBrPurity:99.71% - 99.72%Color and Shape:SolidMolecular weight:412.25VU6001966
CAS:<p>VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.</p>Formula:C17H15FN4O2Purity:98%Color and Shape:SolidMolecular weight:326.33BMT-145027
CAS:<p>BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).</p>Formula:C23H14ClF3N4Purity:99.62%Color and Shape:SolidMolecular weight:438.83MFZ 10-7 hydrochloride
CAS:<p>MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM</p>Formula:C15H10ClFN2Purity:98%Color and Shape:SolidMolecular weight:272.71NS 1209
CAS:<p>NS 1209 (SPD 502) is a AMPA receptor antagonist.</p>Formula:C24H27N4NaO7SPurity:98%Color and Shape:SolidMolecular weight:538.55LY392098
CAS:<p>LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.</p>Formula:C18H22FNO2SPurity:99.86%Color and Shape:SolidMolecular weight:335.44VU 0469650
CAS:<p>VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).</p>Formula:C22H28N4OPurity:98.03%Color and Shape:SolidMolecular weight:364.48(1R,2S)-VU0155041
CAS:<p>(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.</p>Formula:C14H15Cl2NO3Purity:98.85%Color and Shape:SolidMolecular weight:316.18Methoxy-PEPy
CAS:<p>Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.</p>Formula:C13H10N2OPurity:99.22%Color and Shape:SolidMolecular weight:210.23LYPLAL1-IN-1
CAS:<p>LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.</p>Formula:C29H29N7O4Purity:98%Color and Shape:SolidMolecular weight:539.59(RS)-MCPG disodium salt
CAS:<p>group I/group II metabotropic glutamate receptor antagonist</p>Formula:C10H11NNaO4Purity:98%Color and Shape:SolidMolecular weight:232.193,3'-Difluorobenzaldazine
CAS:<p>allosteric potentiator of mGlu5</p>Formula:C14H10F2N2Purity:98%Color and Shape:SolidMolecular weight:244.24VU0366248
CAS:<p>VU0366248 is a mGlu5 negative allosteric modulator.</p>Formula:C14H7ClF2N2OPurity:98%Color and Shape:SolidMolecular weight:292.67L-AP4 monohydrate
CAS:<p>L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).</p>Formula:C4H12NO6PColor and Shape:SolidMolecular weight:201.115VU 0360223
CAS:<p>VU 0360223 is a negative allosteric modulator of mGlu5.</p>Formula:C15H9FN2SPurity:98%Color and Shape:SolidMolecular weight:268.31ADX71743
CAS:<p>ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.</p>Formula:C17H19NO2Color and Shape:SolidMolecular weight:269.34mGlu4 receptor agonist 1
CAS:<p>Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.</p>Formula:C21H15ClN4O2Color and Shape:SolidMolecular weight:390.82MAP4
CAS:<p>metabotropic glutamate receptor modulator</p>Formula:C5H12NO5PPurity:98%Color and Shape:White SolidMolecular weight:197.13GRN-529
CAS:<p>GRN-529 is a selective negative allosteric modulator of the mGluR5 receptor.</p>Formula:C22H15F2N3O2Purity:98%Color and Shape:SolidMolecular weight:391.37DFMTI
CAS:<p>DFMTI can completely block the rmGlu1 L757V glutamate response.</p>Formula:C20H18F2N4OColor and Shape:SolidMolecular weight:368.38Z-Cyclopentyl-AP4
CAS:<p>Group III mGlu receptor agonist</p>Formula:C6H12NO5PPurity:98%Color and Shape:SolidMolecular weight:209.14LY456066
CAS:<p>LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.</p>Formula:C19H23N3OSPurity:98%Color and Shape:SolidMolecular weight:341.47JNJ-40068782
CAS:<p>JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.</p>Formula:C21H23N3OPurity:98%Color and Shape:SolidMolecular weight:333.43TASP0433864
CAS:<p>TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.</p>Formula:C18H23N3O3Purity:98%Color and Shape:SolidMolecular weight:329.39(S)-3,5-DHPG
CAS:<p>group I mGlu receptor agonist</p>Formula:C8H9NO4Purity:98%Color and Shape:SolidMolecular weight:183.16HTL14242
CAS:<p>HTL14242 is a mGlu5 Negative Allosteric Modulator.</p>Formula:C16H8ClFN4Color and Shape:SolidMolecular weight:310.71(RS)-PPG
CAS:<p>(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.</p>Formula:C8H10NO5PPurity:98%Color and Shape:SolidMolecular weight:231.14VU0431316
CAS:<p>VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.</p>Formula:C14H9ClN6O2Purity:98%Color and Shape:SolidMolecular weight:328.71DCG-IV
CAS:<p>DCG-IV: Class II mGluR agonist; anticonvulsant; neuroprotective; EC50: mGlu2R-0.35μM, mGlu3R-0.09μM; antagonizes Group I/III mGluRs.</p>Formula:C7H9NO6Purity:98%Color and Shape:SolidMolecular weight:203.15VU0410425
CAS:<p>VU0410425 is a metabotropic glutamate receptor subtype 1 negative allosteric modulator.</p>Formula:C19H16ClN3O3Purity:98%Color and Shape:SolidMolecular weight:369.8AZ12216052
CAS:<p>AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.</p>Formula:C19H22BrNOSPurity:99.29%Color and Shape:SolidMolecular weight:392.35LY487379 hydrochloride
CAS:<p>Positive allosteric modulator of mGlu2 receptors</p>Formula:C21H20ClF3N2O4SPurity:98%Color and Shape:SolidMolecular weight:488.91VU0361747
CAS:<p>VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).</p>Formula:C19H17FN2O2Color and Shape:SolidMolecular weight:324.35Auglurant
CAS:<p>Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.</p>Formula:C16H12FN5O2Color and Shape:SolidMolecular weight:325.3Desmethyl-YM 298198
CAS:<p>mGlu1-selective antagonist</p>Formula:C17H21ClN4OSPurity:98%Color and Shape:SolidMolecular weight:364.89Foliglurax monohydrochloride
CAS:<p>Foliglurax monohydrochloride, an antiparkinsonian, is a selective brain-penetrant mGluR4 PAM with an EC50 of 79 nM.</p>Formula:C23H24ClN3O3SColor and Shape:SolidMolecular weight:457.97L-CCG-l
CAS:<p>group II metabotropic glutamate receptor agonist</p>Formula:C6H9NO4Purity:98%Color and Shape:SolidMolecular weight:159.14(1S,3R)-ACPD
CAS:<p>(1S,3R)-ACPD is a group I and II mGlu receptor agonist.</p>Formula:C7H11NO4Purity:98%Color and Shape:SolidMolecular weight:173.17VU0404251
CAS:<p>VU0404251 is a positive allosteric modulator of mGlu5.</p>Formula:C19H23FN2O2Color and Shape:SolidMolecular weight:330.4Mavoglurant racemate
CAS:<p>Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.</p>Formula:C19H23NO3Purity:98%Color and Shape:SolidMolecular weight:313.39ACPT-II
CAS:<p>metabotropic receptor antagonist</p>Formula:C8H11NO6Purity:98%Color and Shape:SolidMolecular weight:217.18DL-AP4 Sodium salt
CAS:<p>Broad spectrum EAA ligand</p>Formula:C4H10NNaO5PPurity:98%Color and Shape:SolidMolecular weight:206.09UPF-523
CAS:<p>group I metabotropic glutamate receptors (mGlu1a) antagonist</p>Formula:C11H11NO4Purity:98%Color and Shape:White SolidMolecular weight:221.21JNJ-46356479
CAS:<p>JNJ-46356479: Selective, oral mGlu2 receptor PAM, EC50=78 nM, Emax=256%.</p>Formula:C22H22F5N5Color and Shape:SolidMolecular weight:451.44ACPT-I
CAS:<p>Agonist for group III mGlu receptors</p>Formula:C8H11NO6Purity:98%Color and Shape:SolidMolecular weight:217.18VU0364289
CAS:<p>VU0364289 is a positive allosteric modulator of mGlu5.</p>Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.4(S)-4C3HPG
CAS:<p>group I mGlu1a/1a receptor antagonist and mGluR2 agonist</p>Formula:C9H9NO5Purity:98%Color and Shape:SolidMolecular weight:211.17LSN2814617
CAS:<p>LSN2814617: oral, brain-penetrant mGlu5 PAM, EC50 = 52 nM (human), 42 nM (rat). Promotes wakefulness, useful in schizophrenia study.</p>Formula:C18H20FN5OPurity:98%Color and Shape:SolidMolecular weight:341.38RO4988546
CAS:<p>RO4988546 is a potent negative allosteric modulator of mGlu₂/₃.</p>Formula:C21H10F6N4O3SPurity:98%Color and Shape:SolidMolecular weight:512.38mGluR2 modulator 1
CAS:<p>Potent mGluR2 modulator 1 crosses blood-brain barrier, EC50: 0.03 μM, useful for psychiatric research.</p>Formula:C21H20F3N3O3Color and Shape:SolidMolecular weight:419.4NPEC-caged-LY379268
CAS:<p>NPEC-caged-LY379268 is a type II mGluR agonist [1].</p>Formula:C16H16N2O9Color and Shape:SolidMolecular weight:380.31A 841720
CAS:<p>Potent, selective mGlu1 antagonist A-841720; IC50: 10 nM; 34x selectivity vs mGlu5; analgesic potential.</p>Formula:C17H21N5OSColor and Shape:SolidMolecular weight:343.45RO5488608
CAS:<p>RO5488608 is a new type of high-efficiency mGlu2/3 NAM.</p>Formula:C23H17F3N2O4SColor and Shape:SolidMolecular weight:474.45Talaglumetad hydrochloride
CAS:<p>Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.</p>Formula:C11H17ClN2O5Color and Shape:SolidMolecular weight:292.72mGluR2 modulator 2
CAS:<p>mGluR2 modulator 2: potent, selective, oral, EC50 = 0.13 μM, for antipsychotic research.</p>Formula:C20H22FN3Color and Shape:SolidMolecular weight:323.41VU0418506
CAS:<p>VU0418506 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4).</p>Formula:C12H8ClFN4Purity:98%Color and Shape:SolidMolecular weight:262.67ACDPP hydrochloride
CAS:<p>mGlu5 receptor antagonist</p>Formula:C12H13ClN6OPurity:98%Color and Shape:SolidMolecular weight:292.72Ro 64-5229
CAS:<p>mGlu2 antagonist</p>Formula:C17H19Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:352.26VU6010572
CAS:<p>VU6010572: potent, selective mGlu3 modulator, IC50 245 nM, high CNS penetration.</p>Formula:C20H18FNO3Color and Shape:SolidMolecular weight:339.36VU0463841
CAS:<p>VU0463841 is a mGlu5 negative allosteric modulators.</p>Formula:C13H8ClFN4OColor and Shape:SolidMolecular weight:290.68VU 0360172 hydrochloride
CAS:<p>positive allosteric modulator of mGlu5 receptors</p>Formula:C18H16ClFN2OPurity:98%Color and Shape:SolidMolecular weight:330.78mGluR2 modulator 4
CAS:<p>Compound 47 is a potent mGluR2 enhancer with an EC50 of 0.8 μM, potentially useful for antipsychotic research.</p>Formula:C18H18BrN3Color and Shape:SolidMolecular weight:356.26VU0400195
CAS:<p>VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).</p>Formula:C21H16ClN3O3Purity:98%Color and Shape:SolidMolecular weight:393.82(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:<p>broad spectrum EAA agonist/antagonist</p>Formula:C9H9NO5Purity:98%Color and Shape:SolidMolecular weight:211.17Ro4491533
CAS:<p>Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).</p>Formula:C24H20F3N3OColor and Shape:SolidMolecular weight:423.43MMPIP
CAS:<p>allosteric mGlu7-selective receptor antagonist</p>Formula:C19H15N3O3Purity:98%Color and Shape:SolidMolecular weight:333.34LSP4-2022
CAS:<p>LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.</p>Formula:C13H18NO8PPurity:100%Color and Shape:SolidMolecular weight:347.26VU0424465
CAS:<p>VU0424465 is a mGlu5-selective allosteric agonist.</p>Formula:C19H19FN2O2Color and Shape:SolidMolecular weight:326.36VU0409106
CAS:<p>VU0409106 is a potent, mGlu5-selective inhibitor.</p>Formula:C15H11FN4O2SPurity:98%Color and Shape:SolidMolecular weight:330.34Remeglurant
CAS:<p>Remeglurant is used as a selective antagonist of the mGlu5 receptor.</p>Formula:C17H15BrN4OColor and Shape:SolidMolecular weight:371.23IEM 1925 dihydrobromide
CAS:<p>AMPA receptor antagonist</p>Formula:C17H30Br2N2Purity:98%Color and Shape:SolidMolecular weight:422.24PHCCC(4Me)
CAS:<p>THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.</p>Formula:C18H16N2O3Color and Shape:SolidMolecular weight:308.33MSOP
CAS:<p>MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).</p>Formula:C4H10NO6PPurity:98%Color and Shape:SolidMolecular weight:199.1CFMMC
CAS:<p>CFMMC is an allosteric mGluR1 antagonist agent.</p>Formula:C22H28FNO4Color and Shape:SolidMolecular weight:389.46YM 230888
CAS:<p>Selective mGlu1 antagonist</p>Formula:C19H28N4OSPurity:98%Color and Shape:SolidMolecular weight:360.52LY2607540
CAS:<p>LY2607540 is a metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively).</p>Formula:C24H24F3N3O4Purity:98%Color and Shape:SolidMolecular weight:475.46(S)-HexylHIBO
CAS:<p>Group I mGlu receptor antagonist</p>Formula:C12H20N2O4Purity:98%Color and Shape:SolidMolecular weight:256.3LSP1-2111
CAS:<p>LSP1-2111 is a mGlu4 receptor subtype agonist.</p>Formula:C12H17N2O9PColor and Shape:SolidMolecular weight:364.25Lu-AF11205
CAS:<p>Lu-AF11205 is a potent positive allosteric modulator (PAM) of mGlu5 receptor.</p>Formula:C17H16N2OSPurity:98%Color and Shape:SolidMolecular weight:296.39(RS)-4-Carboxyphenylglycine
CAS:<p>(RS)-4-Carboxyphenylglycine is a racemic mixture. (S)-4-Carboxyphenylglycine is a selective mGlu1α receptor antagonist.</p>Formula:C9H9NO4Purity:99.04% - >99.99%Color and Shape:SolidMolecular weight:195.17(R)-4-Carboxyphenylglycine
CAS:<p>(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.</p>Formula:C9H9NO4Purity:98%Color and Shape:SolidMolecular weight:195.17VU0652835
CAS:<p>VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).</p>Formula:C16H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:333.41JNJ-55511118
CAS:<p>JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.</p>Formula:C14H8ClF3N2O2Color and Shape:SolidMolecular weight:328.67DCB
CAS:<p>DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.</p>Formula:C14H10Cl2N2Purity:99.12% - 99.9%Color and Shape:SolidMolecular weight:277.15ML337
CAS:<p>ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.</p>Formula:C21H20FNO3Purity:99.83%Color and Shape:SolidMolecular weight:353.39LY382884
CAS:<p>LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.</p>Formula:C18H23NO4Purity:98.32% - 98.71%Color and Shape:SolidMolecular weight:317.38TC-N 22A
CAS:<p>TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.</p>Formula:C14H13N5SPurity:99.95%Color and Shape:SolidMolecular weight:283.35CPPHA
CAS:<p>CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.</p>Formula:C22H15ClN2O4Purity:98.07%Color and Shape:SolidMolecular weight:406.82ML289
CAS:<p>ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.</p>Formula:C22H23NO3Purity:99.54%Color and Shape:SolidMolecular weight:349.42Foliglurax
CAS:<p>Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).</p>Formula:C23H23N3O3SPurity:98%Color and Shape:SolidMolecular weight:421.51VU6001376
CAS:<p>VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).</p>Formula:C18H14F2N6OSPurity:98%Color and Shape:SolidMolecular weight:400.41Ro 67-4853
CAS:<p>Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).</p>Formula:C19H19NO4Purity:98.57%Color and Shape:SolidMolecular weight:325.36VU0155041 sodium
CAS:<p>VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.</p>Formula:C14H14Cl2NNaO3Purity:98%Color and Shape:SolidMolecular weight:338.16HexylHIBO
CAS:<p>HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.</p>Formula:C12H20N2O4Purity:99.55%Color and Shape:SolidMolecular weight:256.3(S)-MCPG
CAS:<p>(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.</p>Formula:C10H11NO4Purity:98.72%Color and Shape:SolidMolecular weight:209.20DMeOB
CAS:<p>DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.</p>Formula:C16H16N2O2Purity:98.34%Color and Shape:SolidMolecular weight:268.31A-794282
CAS:<p>A-794282 is a selective antagonist of mGluR1.</p>Formula:C19H18N4OSPurity:99.87%Color and Shape:SolidMolecular weight:350.44
