GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 265 products of "GluR"
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VU0431316
CAS:VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.Formula:C14H9ClN6O2Purity:98%Color and Shape:SolidMolecular weight:328.71(RS)-PPG
CAS:(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.Formula:C8H10NO5PPurity:98%Color and Shape:SolidMolecular weight:231.14JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Formula:C14H8ClF3N2O2Color and Shape:SolidMolecular weight:328.67DCB
CAS:DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.Formula:C14H10Cl2N2Purity:99.12% - 99.9%Color and Shape:SolidMolecular weight:277.15HTL14242
CAS:HTL14242 is a mGlu5 Negative Allosteric Modulator.Formula:C16H8ClFN4Color and Shape:SolidMolecular weight:310.71N,N-Dipropyldopamine (hydrobromide)
CAS:N,N-Dipropyldopamine is a dopamine agonist reducing DOPA and locomotion in rats and mice, reversible by spiroperidol.Formula:C14H24BrNO2Color and Shape:SolidMolecular weight:318.255(S)-3,5-DHPG
CAS:group I mGlu receptor agonistFormula:C8H9NO4Purity:98%Color and Shape:SolidMolecular weight:183.16TASP0433864
CAS:TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.Formula:C18H23N3O3Purity:98%Color and Shape:SolidMolecular weight:329.39ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Formula:C21H20FNO3Purity:99.83%Color and Shape:SolidMolecular weight:353.39Ref: TM-T23003
100mgTo inquire1mg34.00€5mg60.00€1mL*10mM (DMSO)72.00€10mg92.00€25mg195.00€50mg293.00€JNJ-40068782
CAS:JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.Formula:C21H23N3OPurity:98%Color and Shape:SolidMolecular weight:333.43LY456066
CAS:LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.Formula:C19H23N3OSPurity:98%Color and Shape:SolidMolecular weight:341.47Z-Cyclopentyl-AP4
CAS:Group III mGlu receptor agonistFormula:C6H12NO5PPurity:98%Color and Shape:SolidMolecular weight:209.14DFMTI
CAS:DFMTI can completely block the rmGlu1 L757V glutamate response.Formula:C20H18F2N4OColor and Shape:SolidMolecular weight:368.38LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Formula:C18H23NO4Purity:98.32% - 98.71%Color and Shape:SolidMolecular weight:317.38GRN-529
CAS:GRN-529 is a selective negative allosteric modulator of the mGluR5 receptor.Formula:C22H15F2N3O2Purity:98%Color and Shape:SolidMolecular weight:391.37MAP4
CAS:metabotropic glutamate receptor modulatorFormula:C5H12NO5PPurity:98%Color and Shape:White SolidMolecular weight:197.13mGlu4 receptor agonist 1
CAS:Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.Formula:C21H15ClN4O2Color and Shape:SolidMolecular weight:390.82ADX71743
CAS:ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.Formula:C17H19NO2Purity:99.27%Color and Shape:SolidMolecular weight:269.34VU 0360223
CAS:VU 0360223 is a negative allosteric modulator of mGlu5.Formula:C15H9FN2SPurity:98%Color and Shape:SolidMolecular weight:268.31L-AP4 monohydrate
CAS:L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).Formula:C4H12NO6PColor and Shape:SolidMolecular weight:201.115VU0366248
CAS:VU0366248 is a mGlu5 negative allosteric modulator.Formula:C14H7ClF2N2OPurity:98%Color and Shape:SolidMolecular weight:292.673,3'-Difluorobenzaldazine
CAS:allosteric potentiator of mGlu5Formula:C14H10F2N2Purity:98%Color and Shape:SolidMolecular weight:244.24TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Formula:C14H13N5SPurity:99.95%Color and Shape:SolidMolecular weight:283.35(RS)-MCPG disodium salt
CAS:group I/group II metabotropic glutamate receptor antagonistFormula:C10H11NNaO4Purity:98%Color and Shape:SolidMolecular weight:232.19CPPHA
CAS:CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.
Formula:C22H15ClN2O4Purity:98.07%Color and Shape:SolidMolecular weight:406.82ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Formula:C22H23NO3Purity:99.54%Color and Shape:SolidMolecular weight:349.42Ref: TM-T23000
5mg48.00€1mL*10mM (DMSO)49.00€10mg75.00€25mg138.00€50mg212.00€100mg320.00€200mg445.00€LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Formula:C29H29N7O4Purity:98%Color and Shape:SolidMolecular weight:539.59Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Formula:C13H10N2OPurity:98.66%Color and Shape:SolidMolecular weight:210.23(1R,2S)-VU0155041
CAS:(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.Formula:C14H15Cl2NO3Purity:98.85%Color and Shape:SolidMolecular weight:316.18VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Formula:C22H28N4OPurity:98.03%Color and Shape:SolidMolecular weight:364.48Ref: TM-T29118
1mg42.00€5mg79.00€1mL*10mM (DMSO)90.00€10mg108.00€25mg210.00€50mg313.00€100mg464.00€200mg640.00€Foliglurax
CAS:Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).Formula:C23H23N3O3SPurity:98%Color and Shape:SolidMolecular weight:421.51VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Formula:C18H14F2N6OSPurity:98%Color and Shape:SolidMolecular weight:400.41LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Formula:C18H22FNO2SPurity:99.86%Color and Shape:SolidMolecular weight:335.44Ref: TM-T27951
1mg39.00€5mg93.00€1mL*10mM (DMSO)96.00€10mg133.00€25mg215.00€50mg306.00€100mg414.00€200mg573.00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Formula:C24H27N4NaO7SPurity:98%Color and Shape:SolidMolecular weight:538.55Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Formula:C19H19NO4Purity:98.57%Color and Shape:SolidMolecular weight:325.36VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Formula:C14H14Cl2NNaO3Purity:98%Color and Shape:SolidMolecular weight:338.16HexylHIBO
CAS:HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.Formula:C12H20N2O4Purity:99.55%Color and Shape:SolidMolecular weight:256.3(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Formula:C10H11NO4Purity:98.72%Color and Shape:SolidMolecular weight:209.20MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFormula:C15H10ClFN2Purity:98%Color and Shape:SolidMolecular weight:272.71DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Formula:C16H16N2O2Purity:98.34%Color and Shape:SolidMolecular weight:268.31BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Formula:C23H14ClF3N4Purity:99.62%Color and Shape:SolidMolecular weight:438.83A-794282
CAS:A-794282 is a selective antagonist of mGluR1.Formula:C19H18N4OSPurity:99.87%Color and Shape:SolidMolecular weight:350.44(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:broad spectrum EAA agonist/antagonistFormula:C9H9NO5Purity:98%Color and Shape:SolidMolecular weight:211.17Ro4491533
CAS:Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).Formula:C24H20F3N3OColor and Shape:SolidMolecular weight:423.43MMPIP
CAS:allosteric mGlu7-selective receptor antagonistFormula:C19H15N3O3Purity:98%Color and Shape:SolidMolecular weight:333.34LSP4-2022
CAS:LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.Formula:C13H18NO8PPurity:100%Color and Shape:SolidMolecular weight:347.26VU0409106
CAS:VU0409106 is a potent, mGlu5-selective inhibitor.Formula:C15H11FN4O2SPurity:98%Color and Shape:SolidMolecular weight:330.34Remeglurant
CAS:Remeglurant is used as a selective antagonist of the mGlu5 receptor.Formula:C17H15BrN4OColor and Shape:SolidMolecular weight:371.23IEM 1925 dihydrobromide
CAS:AMPA receptor antagonistFormula:C17H30Br2N2Purity:98%Color and Shape:SolidMolecular weight:422.24PHCCC(4Me)
CAS:THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.Formula:C18H16N2O3Color and Shape:SolidMolecular weight:308.33
