AChR
Acetylcholine Receptor (AChR) inhibitors are compounds that block the activity of acetylcholine receptors, which are critical for neurotransmission in the central and peripheral nervous systems. AChRs play a vital role in muscle contraction, memory, and cognitive functions. Inhibitors of AChRs are used to study conditions such as myasthenia gravis, Alzheimer's disease, and other neurological disorders. By modulating AChR activity, these inhibitors can help unravel the complexities of cholinergic signaling in the brain. At CymitQuimica, we provide a range of AChR inhibitors to support your research in neuroscience, pharmacology, and neurodegenerative disease.
Found 644 products of "AChR"
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Piperidolate
CAS:Piperidolate inhibits intestinal cramp induced by acetylcholineFormula:C21H25NO2Purity:98.45%Color and Shape:SolidMolecular weight:323.43Piperidolate hydrochloride
CAS:Piperidolate hydrochloride, an antimuscarinic, reduces acetylcholine-induced intestinal spasms in rats and dogs.Formula:C21H26ClNO2Purity:99.5%Color and Shape:SolidMolecular weight:359.89Rivanicline hemioxalate
Rivanicline hemioxalate is a selective α4β2 nicotinic receptor agonist (K i =26 nM), over 1,000x preference to α7 (K i =3.6 μM), with limited side effects.Formula:C12H16N2O4Purity:98%Color and Shape:SolidMolecular weight:207.23Monepantel
CAS:Monepantel (AAD1566) is an organic anthelmintic and an antagonist of nAChRs from roundworms and esophageostomy.Formula:C20H13F6N3O2SPurity:99.83%Color and Shape:White PowderMolecular weight:473.39Ref: TM-T16126
1mg93.00€5mg236.00€10mg340.00€25mg670.00€50mg964.00€100mg1,378.00€1mL*10mM (DMSO)259.00€Pentoxyverine
CAS:Pentoxyverine (Carbetapentan) is an orally available cough suppressant, an antagonist of muscarinic receptor M1 and an agonist of the σ1 receptor.Formula:C20H31NO3Purity:97.11%Color and Shape:SolidMolecular weight:333.47Velufenacin
CAS:Velufenacin is an antagonist of muscarinic receptor[1].Formula:C19H20ClFN2O2Purity:99.65%Color and Shape:SolidMolecular weight:362.83Ref: TM-T9771
1mg47.00€5mg96.00€10mg156.00€25mg270.00€50mg370.00€100mg522.00€200mg687.00€1mL*10mM (DMSO)105.00€AF-710B
CAS:AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.Formula:C20H27N3OSPurity:98.62% - 99.89%Color and Shape:SolidMolecular weight:357.51Pipecuronium bromide
CAS:Pipecuronium bromide (RGH-1106) is an nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker that causes muscle relaxation.Formula:C35H62Br2N4O4Purity:>99.99%Color and Shape:PowderMolecular weight:762.7Mepenzolate Bromide
CAS:Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.Formula:C21H26BrNO3Purity:95.73% - 99.21%Color and Shape:SolidMolecular weight:420.34Xanomeline tartrate
CAS:Xanomeline tartrate (LY 246708 tartrate) 是 M1和 M4 mAChR 激动剂，具有抗精神病样活性，可改善认知，可用于研究精神分裂症和阿尔茨海默病。Formula:C18H29N3O7SPurity:99.19% - 99.99%Color and Shape:SolidMolecular weight:431.5Varenicline
CAS:Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.Formula:C13H13N3Purity:99.76%Color and Shape:SolidMolecular weight:211.26Ref: TM-T4246L
2mg34.00€5mg50.00€10mg75.00€25mg137.00€50mg200.00€100mg313.00€200mg464.00€1mL*10mM (DMSO)55.00€Pyrantel
CAS:Pyrantel: Nicotinic agonist; causes spastic paralysis in nematodes by depolarizing block.Formula:C11H14N2SPurity:98%Color and Shape:Crystals From Methanol Yellowish Crystalline PowderMolecular weight:206.31Flavoxate
CAS:Flavoxate is an anticholinergic with antimuscarinic effects.
Formula:C24H25NO4Color and Shape:SolidMolecular weight:391.46Atropine hydrobromide
CAS:Atropine hydrobromide is a biochemical.Formula:C17H24BrNO3Color and Shape:SolidMolecular weight:370.28Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formula:C22H28N2O14Purity:98%Color and Shape:SolidMolecular weight:544.46(±)-Atropine-d3 (N-methyl-d3)
CAS:(±)-Atropine-d3 (N-methyl-d3) is a deuterated compound of (±)-Atropine. (±)-Atropine has a CAS number of 51-55-8. Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation.Formula:C17H20D3NO3Color and Shape:SolidMolecular weight:292.39Phenglutarimide hydrochloride
CAS:Phenglutarimide hydrochloride is an anticholinergic. It is used as an antiparkinsonian agent.Formula:C17H25ClN2O2Color and Shape:SolidMolecular weight:324.85VU0029767
CAS:VU0029767 is an allosteric enhancer of the M1 muscarinic receptor, capable of modulating the receptor's activity. This compound enhances M1 receptor activity by increasing agonist affinity. However, VU0029767 demonstrates distinct characteristics from other compounds, particularly under varying experimental conditions such as its interaction with mutated M1 receptors and its effects on downstream signaling pathways.
Formula:C21H21N3O3Color and Shape:SolidMolecular weight:363.41Aprofene
CAS:Aprofene blocks acetylcholine receptors, used for peptic ulcers, endarteritis, cholecystitis, and colitis.Formula:C21H27NO2Color and Shape:SolidMolecular weight:325.44N-Biotinyl p-aminophenyl arsenic acid
CAS:N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that binds to streptavidin and disulfide compounds. It diminishes the binding sites of rbungarotoxin on reduced nicotinic receptors with an IC50 ranging from 10-300 nM, thus shielding the receptors from irreversible alkylation by bromoacetylcholine.Formula:C16H22AsN3O4SColor and Shape:SolidMolecular weight:427.35Catestatin
CAS:Non-competitive inhibitor of nicotinic receptors; blocks cationic signalling and catecholamine release; stimulates histamine release. IC50 ~200-250nM.Formula:C107H173N37O26SPurity:98%Color and Shape:SolidMolecular weight:2425.84AN317
CAS:AN317 is a selective agonist for the nicotinic acetylcholine receptor (nAChR) containing α6β2, with dissociation constants (Ki) of 6.2 nM and 4.1 nM for the α6/α3β2β3 and α4β2 receptor subtypes, respectively. It induces dopamine release in rat striatal synaptosomes, enhances the activity of dopaminergic neurons in the substantia nigra, and exhibits protective effects against the dopaminergic neurotoxin MPP+ in rat neurons. AN317 also demonstrates favorable pharmacokinetic properties in rats and permeability across the blood-brain barrier (BB).Formula:C13H19N3Color and Shape:SolidMolecular weight:217.31Azacyclonol hydrochloride
CAS:Azacyclonol hydrochloride can be used in the treatment of chronic schizophrenia.Formula:C18H22ClNOColor and Shape:Off White Crystalline PowderMolecular weight:303.83Diphenidol
CAS:Diphenidol, a muscarinic antagonist, is employed as an antivertigo and antiemetic agent.Formula:C21H27NOColor and Shape:Needles From Petroleum Ether SolidMolecular weight:309.45Dianicline dihydrochloride
CAS:Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.Formula:C13H16N2OPurity:98%Color and Shape:SolidMolecular weight:216.28Oxantel
CAS:Oxantel is a fumarate reductase inhibitor with anthelmintic activity.Formula:C13H16N2OPurity:98%Color and Shape:SolidMolecular weight:216.28Biperiden lactate
CAS:Biperiden lactate is a biochemical.Formula:C24H35NO4Color and Shape:SolidMolecular weight:401.54Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Formula:C20H17FO2SPurity:99.35%Color and Shape:SolidMolecular weight:340.41Btm 1042
CAS:Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs.Formula:C21H26ClN3OSColor and Shape:SolidMolecular weight:403.97Hyoscyamine hydrobromide
CAS:Hyoscyamine hydrobromide is an agent of anticholinergic.Formula:C17H24BrNO3Purity:98%Color and Shape:SolidMolecular weight:370.28Sazetidine A dihydrochloride
CAS:α4β2 nicotinic acetylcholine receptor ligandFormula:C15H21ClN2O2Purity:98%Color and Shape:SolidMolecular weight:296.79FR 121196
CAS:FR 121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze.Formula:C12H16FN3O3SColor and Shape:SolidMolecular weight:301.34Prifuroline
CAS:Prifuroline is an agent of antiarrhythmic.Formula:C14H16N2OPurity:98%Color and Shape:SolidMolecular weight:228.29Epibatidine 2HCl
CAS:Epibatidine 2HCl is a potent nicotinic agonist.Formula:C11H15Cl3N2Purity:98%Color and Shape:SolidMolecular weight:281.61Flutropium Bromide
CAS:Flutropium Bromide is a competitive antagonist of acetylcholine. It is used to treat asthma and chronic obstructive pulmonary.Formula:C24H29BrFNO3Purity:98%Color and Shape:SolidMolecular weight:478.39Vesamicol
CAS:Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release.Formula:C17H25NOPurity:98%Color and Shape:SolidMolecular weight:259.39Siltenzepine
CAS:Siltenzepine is an agent of anti-acid agent,and used in the treatment of peptic ulcers.Formula:C19H20ClN3O4Purity:98%Color and Shape:SolidMolecular weight:389.83L 858051
CAS:L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes.Formula:C29H48N2O7Color and Shape:SolidMolecular weight:536.7Tarafenacin
CAS:Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor.Formula:C21H20F4N2O2Purity:98%Color and Shape:SolidMolecular weight:408.39LRE1
CAS:LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.Formula:C12H13ClN4SPurity:>99.99%Color and Shape:SolidMolecular weight:280.78Rispenzepine
CAS:Rispenzepine, a novel mAChRs M1/M3 antagonist, treats immune, infections, and respiratory issues.Formula:C19H20N4O2Purity:98%Color and Shape:SolidMolecular weight:336.39Beperidium iodide
CAS:Beperidium iodide is a competitive antagonist of the acetylcholine receptor (pA2: 7.93).Formula:C23H34IN3O3Color and Shape:SolidMolecular weight:527.44WIN 62,577
CAS:WIN 62,577 is a allosteric antagonist of mAChR.Formula:C29H31N3OPurity:98%Color and Shape:SolidMolecular weight:437.58S-(+)-Mecamylamine hydrochloride
CAS:Dexmecamylamine( TC-5214, NIH-11008) is used as a nicotinic channel modulator with antidepressant activity.Formula:C11H22ClNColor and Shape:SolidMolecular weight:203.75Terodiline
CAS:Terodiline is an orally available selective muscarinic M1 receptor and calcium channel antagonist for the study of diseases caused by abnormal bladder function.Formula:C20H27NPurity:98.20% - 99.59%Color and Shape:SolidMolecular weight:281.44Sofiniclin
CAS:Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD).Formula:C10H11Cl2N3Purity:98%Color and Shape:SolidMolecular weight:244.12Methacholine bromide
CAS:Methacholine bromide is a potent M3 agonist for diagnosing asthma by identifying bronchial hyperresponsiveness.Formula:C8H18BrNO2Color and Shape:SolidMolecular weight:240.141Biricodar dicitrate
CAS:Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.Formula:C46H57N3O21Purity:97.78% - 99.78%Color and Shape:SolidMolecular weight:987.95Nuvenzepine
CAS:Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.Formula:C19H20N4O2Purity:98%Color and Shape:SolidMolecular weight:336.39Asoxime dichloride
CAS:Asoxime dichloride (HI-6) blocks AChRs, including α7 nAChR, and boosts vaccination in the nervous system.Formula:C14H16Cl2N4O3Purity:99.75% - 99.86%Color and Shape:SolidMolecular weight:359.21
