Stem Cells
Stem cell inhibitors are compounds that specifically target stem cells and their signaling pathways, affecting their ability to self-renew and differentiate. These inhibitors are crucial in research focused on controlling stem cell behavior, understanding developmental processes, and developing therapies for diseases like cancer, where stem cells are thought to play a key role. At CymitQuimica, we offer a variety of stem cell inhibitors to support your research in regenerative medicine, developmental biology, and oncology.
Found 234 products of "Stem Cells"
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DC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
Formula:C19H17NO2SPurity:99.83%Color and Shape:SoildMolecular weight:323.41F7H
CAS:F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.
Formula:C24H18FN3O2S2Purity:99.85%Color and Shape:SoildMolecular weight:463.55GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.
Formula:C14H10ClN3OSPurity:99.66%Color and Shape:SolidMolecular weight:303.77MSC-5046
MSC-5046 is a selective inhibitor of TEAD1.Formula:C24H18F3N5O3Color and Shape:SolidMolecular weight:481.43Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Formula:C141H218N40O48·C2HF3O2Color and Shape:SolidMolecular weight:3355.5TEAD-IN-16
TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.
Formula:C16H14F3NO3Molecular weight:325.09258HC-258
CAS:HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Formula:C20H24N2O2Color and Shape:SolidMolecular weight:324.42YAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Color and Shape:Odour SolidNIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formula:C18H20N4OPurity:99.87%Color and Shape:SolidMolecular weight:308.38BAY 593
CAS:BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of 38.4 nM in MT-1080 cells and 564 nM in MDA-MB-231 cells, as well as in PXF 541 xenografts.Formula:C26H32ClF3N2O3Color and Shape:SolidMolecular weight:512.99MR24
CAS:MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Formula:C26H29ClN6O3Molecular weight:509.00YAP-TEAD-IN-3
CAS:YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFormula:C27H26ClF2N3O4Purity:97.55% - 98.71%Color and Shape:SoildMolecular weight:529.96CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formula:C23H20BrN3OPurity:99.50%Color and Shape:SolidMolecular weight:434.33Ref: TM-T21685
1mg38.00€5mg71.00€10mg105.00€25mg207.00€50mg329.00€100mg472.00€200mg620.00€1mL*10mM (DMSO)87.00€Rilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Color and Shape:SoildPrafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inColor and Shape:LiquidYAP/TAZ inhibitor-4
YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.Formula:C28H28F3N3O3Color and Shape:SolidMolecular weight:511.54Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formula:C70H113N17O24S2Purity:95.11%Color and Shape:SoildMolecular weight:1640.88TEAD-IN-19
TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.Color and Shape:Odour SolidWAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
Formula:C11H12N2O2S2Purity:99.53%Color and Shape:SoildMolecular weight:268.36Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidLX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formula:C23H29N7O3xHClPurity:98.96%Color and Shape:SolidMolecular weight:487.99TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.5821(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formula:C20H23N7O2SColor and Shape:SolidMolecular weight:425.51YAP/TEAD-IN-1
YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.
Formula:C32H30N8OColor and Shape:SolidMolecular weight:542.634Cirevetmab
CAS:Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.Color and Shape:LiquidS-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Formula:C17H18N6Purity:98%Color and Shape:SolidMolecular weight:306.37Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formula:C17H20N8O2SPurity:99.94%Color and Shape:SoildMolecular weight:400.46JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formula:C14H10ClN3OS2Purity:99.64%Color and Shape:SolidMolecular weight:335.83BAY-593
CAS:BAY-593 is an orally active GGTase-I inhibitor capable of blocking YAP1/TAZ signaling in vivo, exhibiting antitumor activity.Formula:C26H31F3N2O3Color and Shape:SolidMolecular weight:476.53YAP/TAZ inhibitor-1
CAS:YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Formula:C33H39N3O5S2Purity:99.72%Color and Shape:SolidMolecular weight:621.81Anti-GPC3 Antibody (4L576)
Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.Color and Shape:Odour LiquidAnti-SOST Antibody (3R170)
Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.Color and Shape:Odour LiquidIBS008738
CAS:IBS008738 is a TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription.Formula:C22H22N4O2Purity:99.44%Color and Shape:SolidMolecular weight:374.44Anti-NANOG Antibody (1M448)
Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.Purity:>95%Color and Shape:Odour LiquidAnti-5T4/TPBG Antibody (9P872)
Anti-5T4/TPBG Antibody (9P872) is an antibody targeting 5T4/TPBG. Anti-5T4/TPBG Antibody (9P872) can be used in ELISA, FCM.Color and Shape:Odour LiquidCotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurity:98.41%Color and Shape:SolidMolecular weight:319.42Thiazovivin
CAS:Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Formula:C15H13N5OSPurity:98.00%Color and Shape:SolidMolecular weight:311.36Ref: TM-T2155
1mg35.00€2mg48.00€5mg67.00€10mg103.00€25mg190.00€50mg321.00€100mg469.00€1mL*10mM (DMSO)73.00€MYF-01-37
CAS:MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Formula:C15H17F3N2OPurity:99.46% - 99.5%Color and Shape:SolidMolecular weight:298.3Ref: TM-T22372
2mg38.00€5mg57.00€10mg90.00€25mg166.00€50mg281.00€100mg421.00€500mg888.00€1mL*10mM (DMSO)63.00€GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Formula:C21H16F4N4O2Purity:97.68% - 98.49%Color and Shape:SolidMolecular weight:432.37Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formula:C22H19N5OPurity:97.09% - 99.98%Color and Shape:SolidMolecular weight:369.42Ref: TM-T2510
1g657.00€5mg46.00€10mg52.00€25mg84.00€50mg114.00€100mg178.00€200mg269.00€500mg442.00€1mL*10mM (DMSO)52.00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formula:C19H18N4O2Purity:97.72% - 99.75%Color and Shape:SolidMolecular weight:334.37Ref: TM-T1741
1mg43.00€2mg56.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg429.00€1mL*10mM (DMSO)63.00€AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Formula:C12H12N4O4SPurity:>99.99% - ≥95%Color and Shape:SolidMolecular weight:308.31Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formula:C28H36N4O6S2Purity:98.01% - 99.18%Color and Shape:SolidMolecular weight:588.74Ref: TM-T5642
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg210.00€50mg334.00€100mg565.00€1mL*10mM (DMSO)96.00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurity:99.12%Color and Shape:SolidMolecular weight:432.48Ref: TM-T5342
2mg39.00€5mg64.00€10mg101.00€25mg163.00€50mg226.00€100mg320.00€200mg459.00€1mL*10mM (DMSO)70.00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formula:C20H24Br2N4OSPurity:99.67% - ≥95%Color and Shape:SolidMolecular weight:528.3BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formula:C17H13N5Purity:99.87%Color and Shape:SolidMolecular weight:287.32Ref: TM-T8330
1mg50.00€5mg92.00€10mg140.00€25mg273.00€50mg393.00€100mg557.00€200mg753.00€1mL*10mM (DMSO)138.00€Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Formula:C25H19FN4OPurity:99.15%Color and Shape:SolidMolecular weight:410.44LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formula:C24H29N5O3Purity:99.46% - 99.63%Color and Shape:SolidMolecular weight:435.52ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formula:C27H29NO3Purity:99.89% - >99.99%Color and Shape:SolidMolecular weight:415.52
