Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 59 products of "Gamma-secretase"
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LY900009
CAS:<p>LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.</p>Formula:C23H27N3O4Purity:97.07%Color and Shape:SolidMolecular weight:409.48JI130
CAS:<p>JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.</p>Formula:C23H24N2O3Purity:99.61%Color and Shape:SolidMolecular weight:376.45FLI-06
CAS:<p>FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).</p>Formula:C25H30N2O5Purity:99.81% - ≥98%Color and Shape:SolidMolecular weight:438.52γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Formula:C24H25ClN4OSPurity:98%Color and Shape:SolidMolecular weight:453IMR-1A
CAS:<p>IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.</p>Formula:C13H11NO5S2Purity:97.1% - 99.76%Color and Shape:SolidMolecular weight:325.36MK-0752 Sodium
CAS:<p>Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.</p>Formula:C21H21ClF2NaO4SColor and Shape:SolidMolecular weight:465.89RO7185876
CAS:<p>RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.</p>Formula:C25H28F3N7Purity:99.50%Color and Shape:SolidMolecular weight:483.532Dilpacimab
CAS:<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Purity:95% - 95%Color and Shape:LiquidTarlatamab
CAS:<p>"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."</p>Color and Shape:LiquidTarextumab
CAS:<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Purity:95%Color and Shape:Liquidγ-secretase modulator 1
CAS:<p>gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.</p>Formula:C24H24N4OSPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:416.54JI051
CAS:<p>JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.</p>Formula:C22H24N2O3Purity:≥98% - ≥98.0%Color and Shape:SolidMolecular weight:364.44BPN-15606
CAS:<p>BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.</p>Formula:C23H23FN6OColor and Shape:SolidMolecular weight:418.47Yhhu-3792
CAS:<p>Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.</p>Formula:C24H24N4O2Color and Shape:SolidMolecular weight:400.47ELN318463 racemate
CAS:<p>ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.</p>Formula:C19H20BrClN2O3SPurity:99.69%Color and Shape:SolidMolecular weight:471.8γ-secretase modulator 2
CAS:<p>Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.</p>Formula:C25H22F4N6O2Purity:98%Color and Shape:SolidMolecular weight:514.47Aβ42-IN-2
CAS:<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Formula:C24H26N6O2Purity:98.09% - 99.87%Color and Shape:SolidMolecular weight:430.5ELN318463
CAS:<p>ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.</p>Formula:C19H20BrClN2O3SPurity:98%Color and Shape:SolidMolecular weight:471.8CIA-1 hcl(452087-38-6 Free base)
CAS:<p>CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of</p>Formula:C17H20ClN3O2SPurity:99.02%Color and Shape:SolidMolecular weight:365.88γ-Secretase modulator 4
CAS:<p>γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.</p>Formula:C23H19FN4O2Purity:98%Color and Shape:SolidMolecular weight:402.42
